Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases
Magnetic nanoparticles (MNPs) have gained much attention due to their unique properties such as biocompatibility and biodegradability as well as magnetic and heat-medicated characteristics. Due to these inherent properties, MNPs have been widely used in various biomedical applications including targ...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2017-02, Vol.12 (4), p.387-402 |
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| creator | El-Sherbiny, Ibrahim M Elbaz, Nancy M Sedki, Mohammed Elgammal, Abdulaziz Yacoub, Magdi H |
| description | Magnetic nanoparticles (MNPs) have gained much attention due to their unique properties such as biocompatibility and biodegradability as well as magnetic and heat-medicated characteristics. Due to these inherent properties, MNPs have been widely used in various biomedical applications including targeted drug delivery and hyperthermia-based therapy. Hyperthermia is a promising approach for the thermal activation therapy of several diseases, including pulmonary diseases. Additionally, due to their large loading capacity and controlled release ability, several MNP-based drug delivery systems have been emerged for treatment of cystic fibrosis and lung cancer. This review provides an overview on the unique properties of MNPs and magnetic-mediated hyperthermia with emphasis on the recent biomedical applications of MNPs in treatment of both lung cancer and cystic fibrosis. |
| doi_str_mv | 10.2217/nnm-2016-0341 |
| format | Article |
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Due to these inherent properties, MNPs have been widely used in various biomedical applications including targeted drug delivery and hyperthermia-based therapy. Hyperthermia is a promising approach for the thermal activation therapy of several diseases, including pulmonary diseases. Additionally, due to their large loading capacity and controlled release ability, several MNP-based drug delivery systems have been emerged for treatment of cystic fibrosis and lung cancer. This review provides an overview on the unique properties of MNPs and magnetic-mediated hyperthermia with emphasis on the recent biomedical applications of MNPs in treatment of both lung cancer and cystic fibrosis.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>28078950</pmid><doi>10.2217/nnm-2016-0341</doi><tpages>16</tpages></addata></record> |
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| subjects | Animals Cancer therapies Cystic fibrosis Cystic Fibrosis - pathology Cystic Fibrosis - therapy Delayed-Action Preparations - chemistry Delayed-Action Preparations - therapeutic use Drug delivery systems Drug Delivery Systems - methods Gene Transfer Techniques Humans hyperthermia Hyperthermia, Induced - methods iron oxide nanoparticles Lung - pathology lung cancer Lung Neoplasms - pathology Lung Neoplasms - therapy magnetic nanoparticles Magnetism Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - therapeutic use targeted drug delivery |
| title | Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases |
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