The glycocalyx regulates the uptake of nanoparticles by human endothelial cells in vitro

To assess the role of the endothelial glycocalyx (eGCX) for the uptake of nanoparticles by endothelial cells. The expression of the eGCX on cultured human umbilical vein endothelial cells was determined by immunostaining of heparan sulfate. Enzymatic degradation of the eGCX was achieved by incubatin...

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Veröffentlicht in:	Nanomedicine (London, England) England), 2017-02, Vol.12 (3), p.207-217
Hauptverfasser:	Möckl, Leonhard, Hirn, Stephanie, Torrano, Adriano A, Uhl, Bernd, Bräuchle, Christoph, Krombach, Fritz
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival Cells, Cultured Cytotoxicity Glycocalyx - chemistry Glycocalyx - metabolism Heparan sulfate Heparitin Sulfate - chemistry Histamine Homeostasis Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans Hyaluronoglucosaminidase - chemistry Microscopy Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism Neuraminidase - chemistry Permeability Polysaccharide-Lyases - chemistry Polystyrenes - chemistry Surface Properties Veins & arteries
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