Cardiac Calcium Release Channel (Ryanodine Receptor 2) Regulation by Halogenated Anesthetics

BACKGROUND:Halogenated anesthetics activate cardiac ryanodine receptor 2–mediated sarcoplasmic reticulum Ca release, leading to sarcoplasmic reticulum Ca depletion, reduced cardiac function, and providing cell protection against ischemia-reperfusion injury. Anesthetic activation of ryanodine recepto...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2017-03, Vol.126 (3), p.495-506
Hauptverfasser:	Laver, Derek R, Attia, John, Oldmeadow, Christopher, Quail, Anthony W
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - pharmacology Animals Cell Culture Techniques Enflurane - pharmacology Halothane - pharmacology Heart Isoflurane - analogs & derivatives Isoflurane - pharmacology Methyl Ethers - pharmacology Ryanodine Receptor Calcium Release Channel - drug effects Sheep
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