Fatal hyperkalemia related to combined therapy with a COX-2 inhibitor, ACE inhibitor and potassium rich diet

We describe the case of a 77-year old mildly hypertensive woman with no underlying renal disease who was admitted to the Emergency Department (ED) in a comatose state with fever. The patient had been on low dose enalapril and a potassium rich diet. Five days before admission, rofecoxib, a new select...

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Veröffentlicht in:	The Journal of emergency medicine 2002-05, Vol.22 (4), p.349-352
Hauptverfasser:	Hay, Emile, Derazon, Hashmonai, Bukish, Natalia, Katz, Leonid, Kruglyakov, Igor, Armoni, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiotensin-Converting Enzyme Inhibitors - adverse effects Biological and medical sciences Cyclooxygenase Inhibitors - adverse effects cyclooxygenase-2 inhibitor Diet - adverse effects Drug Interactions Drug Therapy, Combination Drug toxicity and drugs side effects treatment Enalapril - adverse effects fatal hyperkalemia Fatal Outcome Female Humans hyperkalemia Hyperkalemia - chemically induced Hypertension - drug therapy Lactones - adverse effects Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Musa NSAID complications Pain - drug therapy Pharmacology. Drug treatments rofecoxib Sulfones
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