HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis

Sphingosine 1-phosphate (S1P) participates in migration of bone marrow (BM)-derived mesenchymal stem cells (BMSCs) toward damaged liver via upregulation of S1P receptor 3 (S1PR3) during mouse liver fibrogenesis. But, the molecular mechanism is still unclear. HuR, as an RNA-binding protein, regulates...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2017, Vol.95 (1), p.69-82
Hauptverfasser:	Chang, Na, Ge, Jingjing, Xiu, Lei, Zhao, Zhongxin, Duan, Xianghui, Tian, Lei, Xie, Jieshi, Yang, Lin, Li, Liying
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Adult Aged Animals Biomedical and Life Sciences Biomedicine Bone marrow Carbon tetrachloride Cell Movement - genetics Disease Models, Animal ELAV-Like Protein 1 - genetics ELAV-Like Protein 1 - metabolism Female Fibrosis Flow cytometry Gene expression Gene Expression Regulation Hepatocytes Human Genetics Humans HuR protein Immunofluorescence Immunoprecipitation Injury analysis Internal Medicine Liver Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Localization Lysophospholipids - metabolism Male Mesenchymal stem cells Mesenchymal Stromal Cells - metabolism Mesenchyme Mice MicroRNAs - genetics Middle Aged Migration Models, Biological Molecular Medicine Motility Nuclei (cytology) Original Article p38 Mitogen-Activated Protein Kinases Phosphates Phosphorylation Positive feedback Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding protein Rodents Signal Transduction siRNA Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine 1-phosphate Stem cell transplantation Stem cells Translocation
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