Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine

Nucleotide activation of skeletal muscle ryanodine receptors (RyRs) was studied in planar lipid bilayers in order to understand RyR regulation in vivo under normal and fatigued conditions. With ârestingâ calcium (100 n m cytoplasmic and 1 m m luminal), RyRs had an open probability ( P o ) of â¼...

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Veröffentlicht in:	The Journal of physiology 2001-12, Vol.537 (3), p.763-778
Hauptverfasser:	Laver, D R, Lenz, G K, Lamb, G D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Adenosine Monophosphate - pharmacology Adenosine Triphosphate - pharmacology AMP Animals Calcium Channels - metabolism IMP Inosine Monophosphate - pharmacology Lipid Bilayers Muscle, Skeletal - metabolism nucleotides Nucleotides - pharmacology Rabbits Ryanodine Receptor Calcium Release Channel - drug effects Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism Time Factors
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