Variation in Access to Kidney Transplantation Across Renal Programs in Ontario, Canada
In the United States, kidney transplant rates vary significantly across end‐stage renal disease (ESRD) networks. We conducted a population‐based cohort study to determine whether there was variability in kidney transplant rates across renal programs in a health care system distinct from the United S...
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Veröffentlicht in: | American journal of transplantation 2017-06, Vol.17 (6), p.1585-1593 |
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creator | Naylor, K. L. Dixon, S. N. Garg, A. X. Kim, S. J. Blake, P. G. Nesrallah, G. E. McCallum, M. K. D'Antonio, C. Li, A. H. Knoll, G. A. |
description | In the United States, kidney transplant rates vary significantly across end‐stage renal disease (ESRD) networks. We conducted a population‐based cohort study to determine whether there was variability in kidney transplant rates across renal programs in a health care system distinct from the United States. We included incident chronic dialysis patients in Ontario, Canada, from 2003 to 2013 and determined the 1‐, 5‐, and 10‐year cumulative incidence of kidney transplantation in 27 regional renal programs (similar to U.S. ESRD networks). We also assessed the cumulative incidence of kidney transplant for “healthy” dialysis patients (aged 18–50 years without diabetes, coronary disease, or malignancy). We calculated standardized transplant ratios (STRs) using a Cox proportional hazards model, adjusting for patient characteristics (maximum possible follow‐up of 11 years). Among 23 022 chronic dialysis patients, the 10‐year cumulative incidence of kidney transplantation ranged from 7.4% (95% confidence interval [CI] 4.8–10.7%) to 31.4% (95% CI 16.5–47.5%) across renal programs. Similar variability was observed in our healthy cohort. STRs ranged from 0.3 (95% CI 0.2–0.5) to 1.5 (95% CI 1.4–1.7) across renal programs. There was significant variation in kidney transplant rates across Ontario renal programs despite patients having access to the same publicly funded health care system.
A population‐based cohort study finds significant variation in kidney transplant rates across Ontario, Canada, renal programs despite patients having access to the same publicly funded healthcare system. |
doi_str_mv | 10.1111/ajt.14133 |
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A population‐based cohort study finds significant variation in kidney transplant rates across Ontario, Canada, renal programs despite patients having access to the same publicly funded healthcare system.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.14133</identifier><identifier>PMID: 28068455</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; clinical research/practice ; Dialysis ; epidemiology ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Health risk assessment ; Health Services Accessibility - statistics & numerical data ; Hemodialysis ; Humans ; Immunology ; Kidney Failure, Chronic - surgery ; Kidney Function Tests ; Kidney transplantation ; Kidney Transplantation - methods ; kidney transplantation/nephrology ; Kidney transplants ; Male ; Middle Aged ; Ontario ; Prognosis ; quality of care/care delivery ; Registries - statistics & numerical data ; Renal Dialysis ; Retrospective Studies ; Risk Factors ; Transplants & implants ; Young Adult</subject><ispartof>American journal of transplantation, 2017-06, Vol.17 (6), p.1585-1593</ispartof><rights>2016 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2016 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><rights>2017 the American Society of Transplantation and the American Society of Transplant Surgeons</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-695da41c16e58dd30d7b5e243600e58497d94fb77b2e7d251f02bae0c52b21cf3</citedby><cites>FETCH-LOGICAL-c3883-695da41c16e58dd30d7b5e243600e58497d94fb77b2e7d251f02bae0c52b21cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajt.14133$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.14133$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28068455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naylor, K. L.</creatorcontrib><creatorcontrib>Dixon, S. N.</creatorcontrib><creatorcontrib>Garg, A. X.</creatorcontrib><creatorcontrib>Kim, S. J.</creatorcontrib><creatorcontrib>Blake, P. G.</creatorcontrib><creatorcontrib>Nesrallah, G. E.</creatorcontrib><creatorcontrib>McCallum, M. K.</creatorcontrib><creatorcontrib>D'Antonio, C.</creatorcontrib><creatorcontrib>Li, A. H.</creatorcontrib><creatorcontrib>Knoll, G. A.</creatorcontrib><title>Variation in Access to Kidney Transplantation Across Renal Programs in Ontario, Canada</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>In the United States, kidney transplant rates vary significantly across end‐stage renal disease (ESRD) networks. We conducted a population‐based cohort study to determine whether there was variability in kidney transplant rates across renal programs in a health care system distinct from the United States. We included incident chronic dialysis patients in Ontario, Canada, from 2003 to 2013 and determined the 1‐, 5‐, and 10‐year cumulative incidence of kidney transplantation in 27 regional renal programs (similar to U.S. ESRD networks). We also assessed the cumulative incidence of kidney transplant for “healthy” dialysis patients (aged 18–50 years without diabetes, coronary disease, or malignancy). We calculated standardized transplant ratios (STRs) using a Cox proportional hazards model, adjusting for patient characteristics (maximum possible follow‐up of 11 years). Among 23 022 chronic dialysis patients, the 10‐year cumulative incidence of kidney transplantation ranged from 7.4% (95% confidence interval [CI] 4.8–10.7%) to 31.4% (95% CI 16.5–47.5%) across renal programs. Similar variability was observed in our healthy cohort. STRs ranged from 0.3 (95% CI 0.2–0.5) to 1.5 (95% CI 1.4–1.7) across renal programs. There was significant variation in kidney transplant rates across Ontario renal programs despite patients having access to the same publicly funded health care system.
A population‐based cohort study finds significant variation in kidney transplant rates across Ontario, Canada, renal programs despite patients having access to the same publicly funded healthcare system.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>clinical research/practice</subject><subject>Dialysis</subject><subject>epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Health risk assessment</subject><subject>Health Services Accessibility - statistics & numerical data</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Immunology</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Function Tests</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - methods</subject><subject>kidney transplantation/nephrology</subject><subject>Kidney transplants</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ontario</subject><subject>Prognosis</subject><subject>quality of care/care delivery</subject><subject>Registries - statistics & numerical data</subject><subject>Renal Dialysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Transplants & implants</subject><subject>Young Adult</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAcBvAgipvTg19ACl4U7JbXJj2W4ftgInPXkjapdLTNTFpk395snTsI5pIQfnn45wHgEsEx8msiV-0YUUTIERiiCMIwQpQcH86EDcCZcysIEccCn4IBFjASlLEhWC6lLWVbmiYomyDJc-1c0JrgtVSN3gQLKxu3rmTT9ibJrfHgXTeyCt6s-bSydtuXcy9sae6CqWykkufgpJCV0xf7fQQ-Hu4X06dwNn98niazMCdCkDCKmZIU5SjSTChFoOIZ05gSP7i_oTFXMS0yzjOsucIMFRBnUsOc4QyjvCAjcNPnrq356rRr07p0ua78xNp0LkWCccIFwpGn13_oynTW_8OrGCIKCaXEq9te7T5qdZGubVlLu0kRTLdlp77sdFe2t1f7xC6rtTrI33Y9mPTgu6z05v-kNHlZ9JE_GjWG6A</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Naylor, K. L.</creator><creator>Dixon, S. N.</creator><creator>Garg, A. X.</creator><creator>Kim, S. J.</creator><creator>Blake, P. G.</creator><creator>Nesrallah, G. E.</creator><creator>McCallum, M. K.</creator><creator>D'Antonio, C.</creator><creator>Li, A. H.</creator><creator>Knoll, G. A.</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Variation in Access to Kidney Transplantation Across Renal Programs in Ontario, Canada</title><author>Naylor, K. L. ; Dixon, S. N. ; Garg, A. X. ; Kim, S. J. ; Blake, P. G. ; Nesrallah, G. E. ; McCallum, M. K. ; D'Antonio, C. ; Li, A. H. ; Knoll, G. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variation in Access to Kidney Transplantation Across Renal Programs in Ontario, Canada</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2017-06</date><risdate>2017</risdate><volume>17</volume><issue>6</issue><spage>1585</spage><epage>1593</epage><pages>1585-1593</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>In the United States, kidney transplant rates vary significantly across end‐stage renal disease (ESRD) networks. We conducted a population‐based cohort study to determine whether there was variability in kidney transplant rates across renal programs in a health care system distinct from the United States. We included incident chronic dialysis patients in Ontario, Canada, from 2003 to 2013 and determined the 1‐, 5‐, and 10‐year cumulative incidence of kidney transplantation in 27 regional renal programs (similar to U.S. ESRD networks). We also assessed the cumulative incidence of kidney transplant for “healthy” dialysis patients (aged 18–50 years without diabetes, coronary disease, or malignancy). We calculated standardized transplant ratios (STRs) using a Cox proportional hazards model, adjusting for patient characteristics (maximum possible follow‐up of 11 years). Among 23 022 chronic dialysis patients, the 10‐year cumulative incidence of kidney transplantation ranged from 7.4% (95% confidence interval [CI] 4.8–10.7%) to 31.4% (95% CI 16.5–47.5%) across renal programs. Similar variability was observed in our healthy cohort. STRs ranged from 0.3 (95% CI 0.2–0.5) to 1.5 (95% CI 1.4–1.7) across renal programs. There was significant variation in kidney transplant rates across Ontario renal programs despite patients having access to the same publicly funded health care system.
A population‐based cohort study finds significant variation in kidney transplant rates across Ontario, Canada, renal programs despite patients having access to the same publicly funded healthcare system.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>28068455</pmid><doi>10.1111/ajt.14133</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Aged Aged, 80 and over clinical research/practice Dialysis epidemiology Female Follow-Up Studies Glomerular Filtration Rate Health risk assessment Health Services Accessibility - statistics & numerical data Hemodialysis Humans Immunology Kidney Failure, Chronic - surgery Kidney Function Tests Kidney transplantation Kidney Transplantation - methods kidney transplantation/nephrology Kidney transplants Male Middle Aged Ontario Prognosis quality of care/care delivery Registries - statistics & numerical data Renal Dialysis Retrospective Studies Risk Factors Transplants & implants Young Adult |
title | Variation in Access to Kidney Transplantation Across Renal Programs in Ontario, Canada |
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