Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms
A high percentage of critical patients are found to develop acute respiratory distress syndrome (ARDS). Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate an...
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| Veröffentlicht in: | Biochemical genetics 2017-06, Vol.55 (3), p.204-211 |
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| creator | Horhat, Florin G. Gundogdu, Fuat David, Laurentiu V. Boia, Eugen S. Pirtea, Laurentiu Horhat, Razvan Cucui-Cozma, Alexandru Ciuca, Ioana Diaconu, Mircea Nitu, Razvan Licker, Monica Horhat, Delia I. Rogobete, Alexandru F. Moise, Marius L. Tataru, Calin |
| description | A high percentage of critical patients are found to develop acute respiratory distress syndrome (ARDS). Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate and monitor ARDS in critical patients. In this regard, the assessment of genetic polymorphisms responsible for developing ARDS present as a challenge and are considered future biomarkers. Early detection of the specific polymorphic gene responsible for ARDS in critically ill patients can prove to be a useful tool in the future, able to help decrease the mortality rates in these cases. Moreover, identifying the genetic polymorphism in these patients can help in the implementation of a personalized intensive therapy scheme for every type of patient, based on its genotype. |
| doi_str_mv | 10.1007/s10528-016-9787-0 |
| format | Article |
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Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate and monitor ARDS in critical patients. In this regard, the assessment of genetic polymorphisms responsible for developing ARDS present as a challenge and are considered future biomarkers. Early detection of the specific polymorphic gene responsible for ARDS in critically ill patients can prove to be a useful tool in the future, able to help decrease the mortality rates in these cases. 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Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate and monitor ARDS in critical patients. In this regard, the assessment of genetic polymorphisms responsible for developing ARDS present as a challenge and are considered future biomarkers. Early detection of the specific polymorphic gene responsible for ARDS in critically ill patients can prove to be a useful tool in the future, able to help decrease the mortality rates in these cases. Moreover, identifying the genetic polymorphism in these patients can help in the implementation of a personalized intensive therapy scheme for every type of patient, based on its genotype.</description><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Critical Illness</subject><subject>Early Diagnosis</subject><subject>Evaluation</subject><subject>Evaluation Studies as Topic</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Medical Microbiology</subject><subject>Mortality</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory Distress Syndrome, Adult - diagnosis</subject><subject>Respiratory Distress Syndrome, Adult - genetics</subject><subject>Respiratory therapy</subject><subject>Review</subject><subject>Sepsis</subject><subject>Zoology</subject><issn>0006-2928</issn><issn>1573-4927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kdFuFCEUhonR2LX6AN4YEm_qxeiBYQe43GzXtkmNTddeE5ZhLM0MjMBo5hF8a5lsNcbEK3LCd_5z4EPoNYH3BIB_SATWVFRAmkpywSt4glZkzeuKScqfohUANBWVVJygFyk9lFICY8_RCRXAoZFshX7udOxnvPuu-0lnFzzWvsWfgnc5ROe_4tDhbXTZGd3jm0JYnxP-4fI93pgpW3xr0-iiLvSMz13K0aaE97NvYxgsPtvcnu_f4bu0RO1Ha1znDL6w3pZEfBP6eQhxvHdpSC_Rs073yb56PE_R3cfdl-1ldf354mq7ua5MzWmueFPTdSP4gVlR27rWXcN4a_WakUa0XGpx6AwILlpNhCFCt8uzyaET5Z4xWZ-is2PuGMO3yaasBpeM7XvtbZiSIqL8IAfR0IK-_Qd9CFP0ZTtFJACThNKFIkfKxJBStJ0aoxt0nBUBtXhSR0-qeFKLJwWl581j8nQYbPun47eYAtAjkMZFg41_jf5v6i9kEJ3d</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Horhat, Florin G.</creator><creator>Gundogdu, Fuat</creator><creator>David, Laurentiu V.</creator><creator>Boia, Eugen S.</creator><creator>Pirtea, Laurentiu</creator><creator>Horhat, Razvan</creator><creator>Cucui-Cozma, Alexandru</creator><creator>Ciuca, Ioana</creator><creator>Diaconu, Mircea</creator><creator>Nitu, Razvan</creator><creator>Licker, Monica</creator><creator>Horhat, Delia I.</creator><creator>Rogobete, Alexandru F.</creator><creator>Moise, Marius L.</creator><creator>Tataru, Calin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1286-4431</orcidid></search><sort><creationdate>20170601</creationdate><title>Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms</title><author>Horhat, Florin G. ; Gundogdu, Fuat ; David, Laurentiu V. ; Boia, Eugen S. ; Pirtea, Laurentiu ; Horhat, Razvan ; Cucui-Cozma, Alexandru ; Ciuca, Ioana ; Diaconu, Mircea ; Nitu, Razvan ; Licker, Monica ; Horhat, Delia I. ; Rogobete, Alexandru F. ; Moise, Marius L. ; Tataru, Calin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-76325687b4e83e33af647dea54168d79a8bfc0878da18c18ad00091bf81684493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Biomarkers - 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Academic</collection><jtitle>Biochemical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horhat, Florin G.</au><au>Gundogdu, Fuat</au><au>David, Laurentiu V.</au><au>Boia, Eugen S.</au><au>Pirtea, Laurentiu</au><au>Horhat, Razvan</au><au>Cucui-Cozma, Alexandru</au><au>Ciuca, Ioana</au><au>Diaconu, Mircea</au><au>Nitu, Razvan</au><au>Licker, Monica</au><au>Horhat, Delia I.</au><au>Rogobete, Alexandru F.</au><au>Moise, Marius L.</au><au>Tataru, Calin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms</atitle><jtitle>Biochemical genetics</jtitle><stitle>Biochem Genet</stitle><addtitle>Biochem Genet</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>55</volume><issue>3</issue><spage>204</spage><epage>211</epage><pages>204-211</pages><issn>0006-2928</issn><eissn>1573-4927</eissn><abstract>A high percentage of critical patients are found to develop acute respiratory distress syndrome (ARDS). 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| subjects | Biochemistry Biomarkers Biomarkers - analysis Biomedical and Life Sciences Biomedicine Critical Illness Early Diagnosis Evaluation Evaluation Studies as Topic Human Genetics Humans Medical Microbiology Mortality Polymorphism Polymorphism, Genetic - genetics Respiratory distress syndrome Respiratory Distress Syndrome, Adult - diagnosis Respiratory Distress Syndrome, Adult - genetics Respiratory therapy Review Sepsis Zoology |
| title | Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms |
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