Impact of donor and recipient adiposity on placental and fetal growth in adolescent sheep
The influence of maternal obesity during oocyte development and its putative interaction with nutrient reserves at conception on pregnancy outcome were examined in an adolescent sheep model. Donor ewes were nutritionally managed to achieve contrasting adiposity (control (CD)/obese (ObD)) for 6 weeks...
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Veröffentlicht in: | Reproduction (Cambridge, England) England), 2017-04, Vol.153 (4), p.381-394 |
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description | The influence of maternal obesity during oocyte development and its putative interaction with nutrient reserves at conception on pregnancy outcome were examined in an adolescent sheep model. Donor ewes were nutritionally managed to achieve contrasting adiposity (control (CD)/obese (ObD)) for 6 weeks prior to superovulation and inseminated by a non-obese sire. Morulae from 6 CD and 7 ObD were transferred in singleton into adolescent recipients of identical age but differing adiposity, classified as relatively fat or thin respectively. Thereafter, all were overnourished to promote rapid growth/adiposity (2 × 2 design, 13/14 pregnancies/group). A fifth recipient group of intermediate adiposity received embryos from another 5 CD, was offered a moderate intake to maintain adiposity throughout gestation and acted as controls for normal pregnancy outcome (optimally treated control (OTC), 19 pregnancies). Donor obesity did not influence ovulation, fertilisation or recovery rates or impact embryo morphology. Gestation length and colostrum yield were unaffected by donor or recipient adiposity and were reduced relative to OTC. Total fetal cotyledon and lamb birth weights were independent of initial donor adiposity but reduced in relatively thin vs relatively fat recipients and lower than those in the OTC group. In spite of high placental efficiency, the incidence of fetal growth restriction was greatest in the thin recipients. Thus, maternal adiposity at conception, but not pre-conception maternal obesity, modestly influences the feto-placental growth trajectory, whereas comparison with the OTC indicates that high gestational intakes to promote rapid maternal growth remain the dominant negative influence on pregnancy outcome in young adolescents. These findings inform dietary advice for pregnant adolescent girls. |
doi_str_mv | 10.1530/REP-16-0590 |
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Donor ewes were nutritionally managed to achieve contrasting adiposity (control (CD)/obese (ObD)) for 6 weeks prior to superovulation and inseminated by a non-obese sire. Morulae from 6 CD and 7 ObD were transferred in singleton into adolescent recipients of identical age but differing adiposity, classified as relatively fat or thin respectively. Thereafter, all were overnourished to promote rapid growth/adiposity (2 × 2 design, 13/14 pregnancies/group). A fifth recipient group of intermediate adiposity received embryos from another 5 CD, was offered a moderate intake to maintain adiposity throughout gestation and acted as controls for normal pregnancy outcome (optimally treated control (OTC), 19 pregnancies). Donor obesity did not influence ovulation, fertilisation or recovery rates or impact embryo morphology. Gestation length and colostrum yield were unaffected by donor or recipient adiposity and were reduced relative to OTC. Total fetal cotyledon and lamb birth weights were independent of initial donor adiposity but reduced in relatively thin vs relatively fat recipients and lower than those in the OTC group. In spite of high placental efficiency, the incidence of fetal growth restriction was greatest in the thin recipients. Thus, maternal adiposity at conception, but not pre-conception maternal obesity, modestly influences the feto-placental growth trajectory, whereas comparison with the OTC indicates that high gestational intakes to promote rapid maternal growth remain the dominant negative influence on pregnancy outcome in young adolescents. These findings inform dietary advice for pregnant adolescent girls.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/REP-16-0590</identifier><identifier>PMID: 28069900</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Adiposity ; Animal Nutritional Physiological Phenomena ; Animals ; Editor's Choice ; Embryo Transfer ; Female ; Fertilization ; Fetal Development - physiology ; Obesity - physiopathology ; Placenta - physiology ; Pregnancy ; Pregnancy Outcome - veterinary ; Sheep ; Tissue Donors</subject><ispartof>Reproduction (Cambridge, England), 2017-04, Vol.153 (4), p.381-394</ispartof><rights>2017 Society for Reproduction and Fertility</rights><rights>2017 Society for Reproduction and Fertility.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b368t-382665802c20aee8f033f62147d8c15a8591e040a039c475911a2942e92f028f3</citedby><cites>FETCH-LOGICAL-b368t-382665802c20aee8f033f62147d8c15a8591e040a039c475911a2942e92f028f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28069900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wallace, Jacqueline M</creatorcontrib><creatorcontrib>Milne, John S</creatorcontrib><creatorcontrib>Adam, Clare L</creatorcontrib><creatorcontrib>Aitken, Raymond P</creatorcontrib><title>Impact of donor and recipient adiposity on placental and fetal growth in adolescent sheep</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>The influence of maternal obesity during oocyte development and its putative interaction with nutrient reserves at conception on pregnancy outcome were examined in an adolescent sheep model. Donor ewes were nutritionally managed to achieve contrasting adiposity (control (CD)/obese (ObD)) for 6 weeks prior to superovulation and inseminated by a non-obese sire. Morulae from 6 CD and 7 ObD were transferred in singleton into adolescent recipients of identical age but differing adiposity, classified as relatively fat or thin respectively. Thereafter, all were overnourished to promote rapid growth/adiposity (2 × 2 design, 13/14 pregnancies/group). A fifth recipient group of intermediate adiposity received embryos from another 5 CD, was offered a moderate intake to maintain adiposity throughout gestation and acted as controls for normal pregnancy outcome (optimally treated control (OTC), 19 pregnancies). Donor obesity did not influence ovulation, fertilisation or recovery rates or impact embryo morphology. Gestation length and colostrum yield were unaffected by donor or recipient adiposity and were reduced relative to OTC. Total fetal cotyledon and lamb birth weights were independent of initial donor adiposity but reduced in relatively thin vs relatively fat recipients and lower than those in the OTC group. In spite of high placental efficiency, the incidence of fetal growth restriction was greatest in the thin recipients. Thus, maternal adiposity at conception, but not pre-conception maternal obesity, modestly influences the feto-placental growth trajectory, whereas comparison with the OTC indicates that high gestational intakes to promote rapid maternal growth remain the dominant negative influence on pregnancy outcome in young adolescents. These findings inform dietary advice for pregnant adolescent girls.</description><subject>Adiposity</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Editor's Choice</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertilization</subject><subject>Fetal Development - physiology</subject><subject>Obesity - physiopathology</subject><subject>Placenta - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - veterinary</subject><subject>Sheep</subject><subject>Tissue Donors</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFLwzAUh4Mobk5P3iVHQaovSZsmRxlTBwNF9OCpZGniIl1Tkw7Zf2_qpkdP773k48d7H0LnBK5JweDmefaUEZ5BIeEAjUmZk6wUUh6mPi8hfVE-QicxfgCQQpT8GI2oAC4lwBi9zded0j32Fte-9QGrtsbBaNc50_ZY1a7z0fVb7FvcNUqnR9X8QNYM3XvwX_0KuzahvjFxAHBcGdOdoiOrmmjO9nWCXu9mL9OHbPF4P5_eLrIl46LPmKCcFwKopqCMERYYs5ym1WuhSaFEIYmBHBQwqfMyTURRmVMjqQUqLJugy11uF_znxsS-Wru0RtOo1vhNrIgoSpauZWVCr3aoDj7GYGzVBbdWYVsRqAaXVXJZEV4NLhN9sQ_eLNem_mN_5SWA7ICl81EPvpx1Wv0b-g2Vx33l</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Wallace, Jacqueline M</creator><creator>Milne, John S</creator><creator>Adam, Clare L</creator><creator>Aitken, Raymond P</creator><general>Bioscientifica Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Impact of donor and recipient adiposity on placental and fetal growth in adolescent sheep</title><author>Wallace, Jacqueline M ; Milne, John S ; Adam, Clare L ; Aitken, Raymond P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b368t-382665802c20aee8f033f62147d8c15a8591e040a039c475911a2942e92f028f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adiposity</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Editor's Choice</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Fertilization</topic><topic>Fetal Development - physiology</topic><topic>Obesity - physiopathology</topic><topic>Placenta - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - veterinary</topic><topic>Sheep</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallace, Jacqueline M</creatorcontrib><creatorcontrib>Milne, John S</creatorcontrib><creatorcontrib>Adam, Clare L</creatorcontrib><creatorcontrib>Aitken, Raymond P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallace, Jacqueline M</au><au>Milne, John S</au><au>Adam, Clare L</au><au>Aitken, Raymond P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of donor and recipient adiposity on placental and fetal growth in adolescent sheep</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>153</volume><issue>4</issue><spage>381</spage><epage>394</epage><pages>381-394</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>The influence of maternal obesity during oocyte development and its putative interaction with nutrient reserves at conception on pregnancy outcome were examined in an adolescent sheep model. Donor ewes were nutritionally managed to achieve contrasting adiposity (control (CD)/obese (ObD)) for 6 weeks prior to superovulation and inseminated by a non-obese sire. Morulae from 6 CD and 7 ObD were transferred in singleton into adolescent recipients of identical age but differing adiposity, classified as relatively fat or thin respectively. Thereafter, all were overnourished to promote rapid growth/adiposity (2 × 2 design, 13/14 pregnancies/group). A fifth recipient group of intermediate adiposity received embryos from another 5 CD, was offered a moderate intake to maintain adiposity throughout gestation and acted as controls for normal pregnancy outcome (optimally treated control (OTC), 19 pregnancies). Donor obesity did not influence ovulation, fertilisation or recovery rates or impact embryo morphology. Gestation length and colostrum yield were unaffected by donor or recipient adiposity and were reduced relative to OTC. Total fetal cotyledon and lamb birth weights were independent of initial donor adiposity but reduced in relatively thin vs relatively fat recipients and lower than those in the OTC group. In spite of high placental efficiency, the incidence of fetal growth restriction was greatest in the thin recipients. Thus, maternal adiposity at conception, but not pre-conception maternal obesity, modestly influences the feto-placental growth trajectory, whereas comparison with the OTC indicates that high gestational intakes to promote rapid maternal growth remain the dominant negative influence on pregnancy outcome in young adolescents. These findings inform dietary advice for pregnant adolescent girls.</abstract><cop>England</cop><pub>Bioscientifica Ltd</pub><pmid>28069900</pmid><doi>10.1530/REP-16-0590</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adiposity Animal Nutritional Physiological Phenomena Animals Editor's Choice Embryo Transfer Female Fertilization Fetal Development - physiology Obesity - physiopathology Placenta - physiology Pregnancy Pregnancy Outcome - veterinary Sheep Tissue Donors |
title | Impact of donor and recipient adiposity on placental and fetal growth in adolescent sheep |
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