ATP-Induced Structural Remodeling in the Antiactivator FleN Enables Formation of the Functional Dimeric Form

FleN, a P loop ATPase is vital for maintaining a monotrichous phenotype in Pseudomonas aeruginosa. FleN exhibits antagonistic activity against FleQ, the master transcriptional regulator of flagellar genes. Crystal structures of FleN in the apo form (1.66 Å) and in complex with β,γ-imidoadenosine 5′-...

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Veröffentlicht in:	Structure (London) 2017-02, Vol.25 (2), p.243-252
Hauptverfasser:	Chanchal, Banerjee, Priyajit, Jain, Deepti
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Amino Acid Sequence antiactivator Apoproteins - chemistry Apoproteins - genetics Apoproteins - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Cloning, Molecular crystal structure Crystallography, X-Ray Escherichia coli - genetics Escherichia coli - metabolism Flagella - genetics Flagella - metabolism FleN Gene Expression Gene Expression Regulation, Bacterial Hydrolysis Kinetics Models, Molecular Mutation Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - metabolism Pseudomonas aeruginosa flagella Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Substrate Specificity Trans-Activators - chemistry Trans-Activators - genetics Trans-Activators - metabolism transcription
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