Cisplatin-induced necroptosis in TNFα dependent and independent pathways

Cisplatin is a chemotherapeutic drug for treatment of many solid tumors. It has been shown to induce apoptosis and/or necrosis in different types of cancer cells. However, the underlying mechanisms remain elusive. In this study, we provide evidences that cisplatin induces necroptosis in receptor-int...

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Veröffentlicht in:	Cellular signalling 2017-02, Vol.31, p.112-123
Hauptverfasser:	Xu, Yanfang, Ma, Hua-bin, Fang, Yu-lu, Zhang, Zhi-rong, Shao, Jing, Hong, Mao, Huang, Chao-jun, Liu, Jing, Chen, Rui-qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Autocrine Communication - drug effects Base Sequence Cisplatin - pharmacology Cyclophilins - metabolism HEK293 Cells HeLa Cells Humans Membrane Potential, Mitochondrial - drug effects Mice Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Membranes - metabolism Mitochondrial Permeability Transition Pore Models, Biological Necrosis Peptidyl-Prolyl Isomerase F Protein Binding - drug effects Protein Kinases - metabolism Protein Transport - drug effects Receptors, Tumor Necrosis Factor, Type I - metabolism Signal Transduction - drug effects Tumor Necrosis Factor-alpha - metabolism
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