Honeycomb structural composite polymer network of gelatin and functional cellulose ester for controlled release of omeprazole

The functionalized cellulose ester MCN was firstly synthesized and used to cross-link gelatin by amidation between −NH2 in gelatin and active ester groups in MCN to form a composite polymer network Gel-MCN, which was confirmed by Van Slyke method, FTIR, XRD and TGA-DTG spectra. The model drug omepra...

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Veröffentlicht in:International journal of biological macromolecules 2017-12, Vol.105 (Pt 3), p.1644-1653
Hauptverfasser: Zhuang, Chen, Shi, Chengmei, Tao, Furong, Cui, Yuezhi
Format: Artikel
Sprache:eng
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Zusammenfassung:The functionalized cellulose ester MCN was firstly synthesized and used to cross-link gelatin by amidation between −NH2 in gelatin and active ester groups in MCN to form a composite polymer network Gel-MCN, which was confirmed by Van Slyke method, FTIR, XRD and TGA-DTG spectra. The model drug omeprazole was loaded in Gel-MCN composites mainly by electrostatic interaction and hydrogen bonds, which were certified by FTIR, XRD and TGA-DSC. Thermal stability, anti-biodegradability, mechanical property and surface hydrophobicity of the composites with different cross-linking extents and drug loading were systematically investigated. SEM images demonstrated the honeycomb structural cells of cross-linked gelatin networks and this ensured drug entrapment. The drug release mechanism was dominated by a combined effect of diffusion and degradation, and the release rate decreased with cross-linking degree increased. The developed drug delivery system had profound significance in improving pesticide effect and bioavailability of drugs.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2017.01.019