NHC-catalyzed [4 + 2] annulation of 2-bromo-2-enals with acylhydrazones: enantioselective synthesis of δ-lactams

NHC-catalyzed [4 + 2] annulation of 2-bromo-2-enals with acylhydrazones: enantioselective synthesis of δ-lactams

An asymmetric assembly of δ-lactams was realized via the NHC-catalyzed formal [4 + 2] annulation of acylhydrazones and 2-bromo-2-enals bearing γ-H. The advantages of this protocol include high enantioselectivity, good yields, mild reaction conditions and potential biological significance of the fina...

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Veröffentlicht in:Organic & biomolecular chemistry 2017-01, Vol.15 (4), p.991-997
Hauptverfasser: Sun, Baomin, Gao, Lijiu, Shen, Shide, Yu, Chenxia, Li, Tuanjie, Xie, Yuanwei, Yao, Changsheng
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container_issue 4
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container_title Organic & biomolecular chemistry
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creator Sun, Baomin
Gao, Lijiu
Shen, Shide
Yu, Chenxia
Li, Tuanjie
Xie, Yuanwei
Yao, Changsheng
description An asymmetric assembly of δ-lactams was realized via the NHC-catalyzed formal [4 + 2] annulation of acylhydrazones and 2-bromo-2-enals bearing γ-H. The advantages of this protocol include high enantioselectivity, good yields, mild reaction conditions and potential biological significance of the final products.
doi_str_mv 10.1039/c6ob02253g
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title NHC-catalyzed [4 + 2] annulation of 2-bromo-2-enals with acylhydrazones: enantioselective synthesis of δ-lactams
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