Physicochemical and antimicrobial properties of copaiba oil: implications on product quality control
The copaiba oil is a common natural product used in cosmetic industry and as a nutraceutical product. However, lack of quality control and scarce knowledge about its antimicrobial activity is a point of concern. The proposal of this study was to investigate the physicochemical properties and the ant...
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| Veröffentlicht in: | Acta Scientiarum Polonorum. Technologia Alimentaria 2015-07, Vol.14 (3), p.215-225 |
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| creator | Fonseca, Renata G Barros, Francisco M Apel, Miriam A Poser, Gilsane L von Andriolli, Jo O L Filho, Pedro C Campos Sousa, Dhierlate F Lobo, Ivon P Conceiç O, Aline O |
| description | The copaiba oil is a common natural product used in cosmetic industry and as a nutraceutical product. However, lack of quality control and scarce knowledge about its antimicrobial activity is a point of concern. The proposal of this study was to investigate the physicochemical properties and the antimicrobial activity of five commercial brands of copaiba oil.
Acidity and ester index, refractory index, solubility in alcohol, and thin layer chromatography were performed to verify the physicochemical properties of five commercial copaiba oils sold in local pharmacies. Ultra performance liquid chromatography coupled with diode-array detection and electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-DAD/ESI-Q-TOF-MS) was used to investigate diterpene acids while the volatile compounds were analysed by gas chromatography-mass spectrometry (GC-MS). Antibacterial and antifungal activities were also evaluated by agar diffusion technique; and minimal inhibitory concentration and maximal bactericidal concentration were defined for each sample and bacteria.
The physical-chemical analysis revealed heterogeneity between all samples analysed. The A1 sample showed characteristics of copaiba oil and was mainly composed by hydrocarbon sesquiterpenes (29.95% β-bisabolene, 25.65% Z-α-bergamotene and 10.27% β-cariophyllene). Among diterpene acids, the UPLCDAD/ESI-Q-TOF-MS data are compatible with presence of copalic and/or kolavenic acid (m/z 305 [M + H]+). Candida albicans was sensitive to almost all samples at high concentration and Saccaromyces. Cerevisiae showed sensitivity to A1 sample at 100 mg/mL. Although variable, all samples showed antibacterial activity. Significant activity was seen for A3 (19.0 ±0 and 15.6 ±0.5 mm), A4 (16.6 ±0.5 and 15.6 ±0 mm), and A5 (17.1 ±0 and 17.1 ±0 mm) on Staphylococcus saprophyticus and S. aureus, respectively. All samples were active against Klebsiella pneumoniae showing ≥15 mm diameter halo inhibition; and only A2 was active against Eschirichia coli. Phytopatogens tested revealed resistance of Ralstonia solanacearum CGH12 to all samples and susceptibility of Xcv 112 strain of Xanthomonas campestris pv campestris to almost all samples. MIC and MMC showed bacteriostatic effect against clinical interest bacteria and bactericidal effect against phytopatogens.
The results from physicochemical analysis reinforce the fact that it is imperative to include simple conventional methods in the analysis of oil products. The ana |
| doi_str_mv | 10.17306/J.AFS.2015.3.23 |
| format | Article |
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Acidity and ester index, refractory index, solubility in alcohol, and thin layer chromatography were performed to verify the physicochemical properties of five commercial copaiba oils sold in local pharmacies. Ultra performance liquid chromatography coupled with diode-array detection and electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-DAD/ESI-Q-TOF-MS) was used to investigate diterpene acids while the volatile compounds were analysed by gas chromatography-mass spectrometry (GC-MS). Antibacterial and antifungal activities were also evaluated by agar diffusion technique; and minimal inhibitory concentration and maximal bactericidal concentration were defined for each sample and bacteria.
The physical-chemical analysis revealed heterogeneity between all samples analysed. The A1 sample showed characteristics of copaiba oil and was mainly composed by hydrocarbon sesquiterpenes (29.95% β-bisabolene, 25.65% Z-α-bergamotene and 10.27% β-cariophyllene). Among diterpene acids, the UPLCDAD/ESI-Q-TOF-MS data are compatible with presence of copalic and/or kolavenic acid (m/z 305 [M + H]+). Candida albicans was sensitive to almost all samples at high concentration and Saccaromyces. Cerevisiae showed sensitivity to A1 sample at 100 mg/mL. Although variable, all samples showed antibacterial activity. Significant activity was seen for A3 (19.0 ±0 and 15.6 ±0.5 mm), A4 (16.6 ±0.5 and 15.6 ±0 mm), and A5 (17.1 ±0 and 17.1 ±0 mm) on Staphylococcus saprophyticus and S. aureus, respectively. All samples were active against Klebsiella pneumoniae showing ≥15 mm diameter halo inhibition; and only A2 was active against Eschirichia coli. Phytopatogens tested revealed resistance of Ralstonia solanacearum CGH12 to all samples and susceptibility of Xcv 112 strain of Xanthomonas campestris pv campestris to almost all samples. MIC and MMC showed bacteriostatic effect against clinical interest bacteria and bactericidal effect against phytopatogens.
The results from physicochemical analysis reinforce the fact that it is imperative to include simple conventional methods in the analysis of oil products. The analysis of copaiba oil gives safe products and purity which ensure products with quality. Also, since copaiba oil is an over-the-counter product the results indicate that pharmacosurveillance must be improved by the governmental regulation agency to avoid microorganism resistance selection and to achieve better international quality products.</description><identifier>ISSN: 1644-0730</identifier><identifier>EISSN: 1898-9594</identifier><identifier>DOI: 10.17306/J.AFS.2015.3.23</identifier><identifier>PMID: 28068029</identifier><language>eng</language><publisher>Poland</publisher><subject>Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Brazil ; Chemical Phenomena ; Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Dietary Supplements - analysis ; Dietary Supplements - economics ; Disk Diffusion Antimicrobial Tests ; Fabaceae - chemistry ; Food Quality ; Gas Chromatography-Mass Spectrometry ; Gram-Negative Bacteria - drug effects ; Gram-Negative Bacteria - growth & development ; Gram-Positive Bacteria - drug effects ; Gram-Positive Bacteria - growth & development ; Hydrogen-Ion Concentration ; Plant Oils - chemistry ; Plant Oils - economics ; Solubility ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry ; Terpenes - analysis ; Terpenes - chemistry ; Terpenes - pharmacology ; Volatile Organic Compounds - analysis ; Volatile Organic Compounds - chemistry ; Volatile Organic Compounds - pharmacology ; Yeasts - drug effects ; Yeasts - growth & development</subject><ispartof>Acta Scientiarum Polonorum. Technologia Alimentaria, 2015-07, Vol.14 (3), p.215-225</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-f069748c0f8a2180a44e6a1e9433cdf2d83d96bbb22506e03d5f7729609f1f5d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28068029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fonseca, Renata G</creatorcontrib><creatorcontrib>Barros, Francisco M</creatorcontrib><creatorcontrib>Apel, Miriam A</creatorcontrib><creatorcontrib>Poser, Gilsane L von</creatorcontrib><creatorcontrib>Andriolli, Jo O L</creatorcontrib><creatorcontrib>Filho, Pedro C Campos</creatorcontrib><creatorcontrib>Sousa, Dhierlate F</creatorcontrib><creatorcontrib>Lobo, Ivon P</creatorcontrib><creatorcontrib>Conceiç O, Aline O</creatorcontrib><creatorcontrib>Basic and Instrumental Studies Department, State University of Southeast Bahia, Itapetinga, Bahia, Brazil</creatorcontrib><creatorcontrib>Pharmaceutical Science Graduate Program, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil</creatorcontrib><creatorcontrib>Exact and Technological Sciences Department, State University</creatorcontrib><creatorcontrib>Biological Science Department, State University of Santa Cruz, Ilheus, Bahia, Brazil</creatorcontrib><title>Physicochemical and antimicrobial properties of copaiba oil: implications on product quality control</title><title>Acta Scientiarum Polonorum. Technologia Alimentaria</title><addtitle>Acta Sci Pol Technol Aliment</addtitle><description>The copaiba oil is a common natural product used in cosmetic industry and as a nutraceutical product. However, lack of quality control and scarce knowledge about its antimicrobial activity is a point of concern. The proposal of this study was to investigate the physicochemical properties and the antimicrobial activity of five commercial brands of copaiba oil.
Acidity and ester index, refractory index, solubility in alcohol, and thin layer chromatography were performed to verify the physicochemical properties of five commercial copaiba oils sold in local pharmacies. Ultra performance liquid chromatography coupled with diode-array detection and electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-DAD/ESI-Q-TOF-MS) was used to investigate diterpene acids while the volatile compounds were analysed by gas chromatography-mass spectrometry (GC-MS). Antibacterial and antifungal activities were also evaluated by agar diffusion technique; and minimal inhibitory concentration and maximal bactericidal concentration were defined for each sample and bacteria.
The physical-chemical analysis revealed heterogeneity between all samples analysed. The A1 sample showed characteristics of copaiba oil and was mainly composed by hydrocarbon sesquiterpenes (29.95% β-bisabolene, 25.65% Z-α-bergamotene and 10.27% β-cariophyllene). Among diterpene acids, the UPLCDAD/ESI-Q-TOF-MS data are compatible with presence of copalic and/or kolavenic acid (m/z 305 [M + H]+). Candida albicans was sensitive to almost all samples at high concentration and Saccaromyces. Cerevisiae showed sensitivity to A1 sample at 100 mg/mL. Although variable, all samples showed antibacterial activity. Significant activity was seen for A3 (19.0 ±0 and 15.6 ±0.5 mm), A4 (16.6 ±0.5 and 15.6 ±0 mm), and A5 (17.1 ±0 and 17.1 ±0 mm) on Staphylococcus saprophyticus and S. aureus, respectively. All samples were active against Klebsiella pneumoniae showing ≥15 mm diameter halo inhibition; and only A2 was active against Eschirichia coli. Phytopatogens tested revealed resistance of Ralstonia solanacearum CGH12 to all samples and susceptibility of Xcv 112 strain of Xanthomonas campestris pv campestris to almost all samples. MIC and MMC showed bacteriostatic effect against clinical interest bacteria and bactericidal effect against phytopatogens.
The results from physicochemical analysis reinforce the fact that it is imperative to include simple conventional methods in the analysis of oil products. The analysis of copaiba oil gives safe products and purity which ensure products with quality. Also, since copaiba oil is an over-the-counter product the results indicate that pharmacosurveillance must be improved by the governmental regulation agency to avoid microorganism resistance selection and to achieve better international quality products.</description><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Brazil</subject><subject>Chemical Phenomena</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chromatography, Thin Layer</subject><subject>Dietary Supplements - analysis</subject><subject>Dietary Supplements - economics</subject><subject>Disk Diffusion Antimicrobial Tests</subject><subject>Fabaceae - chemistry</subject><subject>Food Quality</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Negative Bacteria - growth & development</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - growth & development</subject><subject>Hydrogen-Ion Concentration</subject><subject>Plant Oils - chemistry</subject><subject>Plant Oils - economics</subject><subject>Solubility</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Tandem Mass Spectrometry</subject><subject>Terpenes - analysis</subject><subject>Terpenes - chemistry</subject><subject>Terpenes - pharmacology</subject><subject>Volatile Organic Compounds - analysis</subject><subject>Volatile Organic Compounds - chemistry</subject><subject>Volatile Organic Compounds - pharmacology</subject><subject>Yeasts - drug effects</subject><subject>Yeasts - growth & development</subject><issn>1644-0730</issn><issn>1898-9594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PxDAMhiME4uBgZ0IdWVqcpE0TthPi-BASSMAcpfkQQW3Ta9rh_j05OBgix_bzWvaL0AWGAtcU2PVTsVq_FQRwVdCC0AN0grnguahEeZj-rCxzSOACncb4BVBxwOQYLQgHxoGIE2ReP7fR66A_bee1ajPVm_Qmn7IxND5VhjEMdpy8jVlwmQ6D8o3Kgm9vMt8NbVJNPvSp2e9QM-sp28yq9dM2wf00hvYMHTnVRnu-j0v0sb57v33In1_uH29Xz7mmJZ5yB0zUJdfguCKYgypLyxS2oqRUG0cMp0awpmkIqYBZoKZydU0EA-GwqwxdoqvfuWmPzWzjJDsftW1b1dswR4l5xTirMfCEwi-aroxxtE4Oo-_UuJUY5I-38kkmb-XOW0kloUlyuZ8-N501_4I_M-k3EWZ2Wg</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Fonseca, Renata G</creator><creator>Barros, Francisco M</creator><creator>Apel, Miriam A</creator><creator>Poser, Gilsane L von</creator><creator>Andriolli, Jo O L</creator><creator>Filho, Pedro C Campos</creator><creator>Sousa, Dhierlate F</creator><creator>Lobo, Ivon P</creator><creator>Conceiç O, Aline O</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Physicochemical and antimicrobial properties of copaiba oil: implications on product quality control</title><author>Fonseca, Renata G ; Barros, Francisco M ; Apel, Miriam A ; Poser, Gilsane L von ; Andriolli, Jo O L ; Filho, Pedro C Campos ; Sousa, Dhierlate F ; Lobo, Ivon P ; Conceiç O, Aline O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-f069748c0f8a2180a44e6a1e9433cdf2d83d96bbb22506e03d5f7729609f1f5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Brazil</topic><topic>Chemical Phenomena</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Chromatography, Thin Layer</topic><topic>Dietary Supplements - analysis</topic><topic>Dietary Supplements - economics</topic><topic>Disk Diffusion Antimicrobial Tests</topic><topic>Fabaceae - chemistry</topic><topic>Food Quality</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Negative Bacteria - growth & development</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - growth & development</topic><topic>Hydrogen-Ion Concentration</topic><topic>Plant Oils - chemistry</topic><topic>Plant Oils - economics</topic><topic>Solubility</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Tandem Mass Spectrometry</topic><topic>Terpenes - analysis</topic><topic>Terpenes - chemistry</topic><topic>Terpenes - pharmacology</topic><topic>Volatile Organic Compounds - analysis</topic><topic>Volatile Organic Compounds - chemistry</topic><topic>Volatile Organic Compounds - pharmacology</topic><topic>Yeasts - drug effects</topic><topic>Yeasts - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fonseca, Renata G</creatorcontrib><creatorcontrib>Barros, Francisco M</creatorcontrib><creatorcontrib>Apel, Miriam A</creatorcontrib><creatorcontrib>Poser, Gilsane L von</creatorcontrib><creatorcontrib>Andriolli, Jo O L</creatorcontrib><creatorcontrib>Filho, Pedro C Campos</creatorcontrib><creatorcontrib>Sousa, Dhierlate F</creatorcontrib><creatorcontrib>Lobo, Ivon P</creatorcontrib><creatorcontrib>Conceiç O, Aline O</creatorcontrib><creatorcontrib>Basic and Instrumental Studies Department, State University of Southeast Bahia, Itapetinga, Bahia, Brazil</creatorcontrib><creatorcontrib>Pharmaceutical Science Graduate Program, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil</creatorcontrib><creatorcontrib>Exact and Technological Sciences Department, State University</creatorcontrib><creatorcontrib>Biological Science Department, State University of Santa Cruz, Ilheus, Bahia, Brazil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Scientiarum Polonorum. Technologia Alimentaria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fonseca, Renata G</au><au>Barros, Francisco M</au><au>Apel, Miriam A</au><au>Poser, Gilsane L von</au><au>Andriolli, Jo O L</au><au>Filho, Pedro C Campos</au><au>Sousa, Dhierlate F</au><au>Lobo, Ivon P</au><au>Conceiç O, Aline O</au><aucorp>Basic and Instrumental Studies Department, State University of Southeast Bahia, Itapetinga, Bahia, Brazil</aucorp><aucorp>Pharmaceutical Science Graduate Program, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil</aucorp><aucorp>Exact and Technological Sciences Department, State University</aucorp><aucorp>Biological Science Department, State University of Santa Cruz, Ilheus, Bahia, Brazil</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physicochemical and antimicrobial properties of copaiba oil: implications on product quality control</atitle><jtitle>Acta Scientiarum Polonorum. Technologia Alimentaria</jtitle><addtitle>Acta Sci Pol Technol Aliment</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>14</volume><issue>3</issue><spage>215</spage><epage>225</epage><pages>215-225</pages><issn>1644-0730</issn><eissn>1898-9594</eissn><abstract>The copaiba oil is a common natural product used in cosmetic industry and as a nutraceutical product. However, lack of quality control and scarce knowledge about its antimicrobial activity is a point of concern. The proposal of this study was to investigate the physicochemical properties and the antimicrobial activity of five commercial brands of copaiba oil.
Acidity and ester index, refractory index, solubility in alcohol, and thin layer chromatography were performed to verify the physicochemical properties of five commercial copaiba oils sold in local pharmacies. Ultra performance liquid chromatography coupled with diode-array detection and electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-DAD/ESI-Q-TOF-MS) was used to investigate diterpene acids while the volatile compounds were analysed by gas chromatography-mass spectrometry (GC-MS). Antibacterial and antifungal activities were also evaluated by agar diffusion technique; and minimal inhibitory concentration and maximal bactericidal concentration were defined for each sample and bacteria.
The physical-chemical analysis revealed heterogeneity between all samples analysed. The A1 sample showed characteristics of copaiba oil and was mainly composed by hydrocarbon sesquiterpenes (29.95% β-bisabolene, 25.65% Z-α-bergamotene and 10.27% β-cariophyllene). Among diterpene acids, the UPLCDAD/ESI-Q-TOF-MS data are compatible with presence of copalic and/or kolavenic acid (m/z 305 [M + H]+). Candida albicans was sensitive to almost all samples at high concentration and Saccaromyces. Cerevisiae showed sensitivity to A1 sample at 100 mg/mL. Although variable, all samples showed antibacterial activity. Significant activity was seen for A3 (19.0 ±0 and 15.6 ±0.5 mm), A4 (16.6 ±0.5 and 15.6 ±0 mm), and A5 (17.1 ±0 and 17.1 ±0 mm) on Staphylococcus saprophyticus and S. aureus, respectively. All samples were active against Klebsiella pneumoniae showing ≥15 mm diameter halo inhibition; and only A2 was active against Eschirichia coli. Phytopatogens tested revealed resistance of Ralstonia solanacearum CGH12 to all samples and susceptibility of Xcv 112 strain of Xanthomonas campestris pv campestris to almost all samples. MIC and MMC showed bacteriostatic effect against clinical interest bacteria and bactericidal effect against phytopatogens.
The results from physicochemical analysis reinforce the fact that it is imperative to include simple conventional methods in the analysis of oil products. The analysis of copaiba oil gives safe products and purity which ensure products with quality. Also, since copaiba oil is an over-the-counter product the results indicate that pharmacosurveillance must be improved by the governmental regulation agency to avoid microorganism resistance selection and to achieve better international quality products.</abstract><cop>Poland</cop><pmid>28068029</pmid><doi>10.17306/J.AFS.2015.3.23</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Brazil Chemical Phenomena Chromatography, High Pressure Liquid Chromatography, Thin Layer Dietary Supplements - analysis Dietary Supplements - economics Disk Diffusion Antimicrobial Tests Fabaceae - chemistry Food Quality Gas Chromatography-Mass Spectrometry Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - growth & development Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - growth & development Hydrogen-Ion Concentration Plant Oils - chemistry Plant Oils - economics Solubility Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Terpenes - analysis Terpenes - chemistry Terpenes - pharmacology Volatile Organic Compounds - analysis Volatile Organic Compounds - chemistry Volatile Organic Compounds - pharmacology Yeasts - drug effects Yeasts - growth & development |
| title | Physicochemical and antimicrobial properties of copaiba oil: implications on product quality control |
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