Acidic pH with coordinated reduction of basic fibroblast growth factor maintains the glioblastoma stem cell-like phenotype in vitro

Glioblastoma stem cells (GSCs) are a unique subpopulation of cells within glioblastoma multiforme (GBM) brain tumors that possess the ability to self-renew and differentiate into bulk tumor cells. GSCs are resistant to currently available treatments and are the likely culprit behind tumor relapse in...

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Veröffentlicht in:	Journal of bioscience and bioengineering 2017-05, Vol.123 (5), p.634-641
Hauptverfasser:	Haley, Elizabeth M., Tilson, Samantha G., Triantafillu, Ursula L., Magrath, Justin W., Kim, Yonghyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidic pH Acids - chemistry Basic fibroblast growth factor Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer stem cells Cell Line, Tumor Cell Proliferation - drug effects Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factor 2 - pharmacology Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Glioblastoma stem cells Humans Hydrogen-Ion Concentration Neoplastic Stem Cells - pathology Phenotype
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