Development of l‑Tyrosine-Based Enzyme-Responsive Amphiphilic Poly(ester-urethane) Nanocarriers for Multiple Drug Delivery to Cancer Cells

New classes of enzymatic-biodegradable amphiphilic poly(ester-urethane)s were designed and developed from l-tyrosine amino acid resources and their self-assembled nanoparticles were employed as multiple drug delivery vehicles in cancer therapy. The amine and carboxylic acid functional groups in l-...

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Veröffentlicht in:	Biomacromolecules 2017-01, Vol.18 (1), p.189-200
Hauptverfasser:	Aluri, Rajendra, Jayakannan, Manickam
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Biocompatible Materials Camptothecin - pharmacology Cell Survival - drug effects Doxorubicin - pharmacology Drug Carriers - chemistry Drug Delivery Systems Drug Liberation HeLa Cells Humans Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Nanoparticles - administration & dosage Nanoparticles - chemistry Polyesters - chemistry Polymers - administration & dosage Polymers - chemistry Polyurethanes - chemistry Tyrosine - chemistry
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