Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines
Licochalcone A (LicA), an oxygenated chalcone, has been shown to inhibit the growth of both parasites and bacteria. In this study, we investigated the effect of LicA and four synthetic analogues on the activity of human peripheral blood mononuclear cell proliferation and cytokine production. Four ou...
Gespeichert in:
| Veröffentlicht in: | International immunopharmacology 2002-03, Vol.2 (4), p.545-555 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 555 |
|---|---|
| container_issue | 4 |
| container_start_page | 545 |
| container_title | International immunopharmacology |
| container_volume | 2 |
| creator | Barfod, Lea Kemp, Kåre Hansen, Majbritt Kharazmi, Arsalan |
| description | Licochalcone A (LicA), an oxygenated chalcone, has been shown to inhibit the growth of both parasites and bacteria. In this study, we investigated the effect of LicA and four synthetic analogues on the activity of human peripheral blood mononuclear cell proliferation and cytokine production. Four out of five chalcones tested inhibited the proliferation of lymphocytes measured by thymidine incorporation and by flow cytometry. The production of pro- and anti-inflammatory cytokines from monocytes and T cells was also inhibited by four of five chalcones. Furthermore, intracellular detection of cytokines revealed that the chalcones inhibited the production rather than the release of the cytokines. Taken together, these results indicate that LicA and some analogues may have immunomodulatory effects, and may thus be candidates not only as anti-microbial agents, but also for the treatment of other types of diseases. |
| doi_str_mv | 10.1016/S1567-5769(01)00202-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_18568019</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1567576901002028</els_id><sourcerecordid>18568019</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-9bee48d3bd63a5ae4f6cd86393ab4f5eccda9a242b1a7bd1915b435ac23ea3733</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhi1ExVf7E0C-UNFDqCeOneSEqlVbKiFxKD1W1sSeaA3ZGOykEv--DruIIyePPM-MXz-MnYK4BAH6629Qui5UrdsLAV-EKEVZNHvsCJq6KaAWaj_Xr8ghO07pXoh8X8EBOwRodVlLecT-rtY42DBS4n0MG75a-1wTH_zTHKK3xP249p2f-GMMg-8p4uTDyEPP77ilYUgcR7c03WxfO_Z5Cg_Lno_sQ49Dok-784T9-fH9bnVd3Nz-_LX6dlPYqiynou2IqsbJzmmJCqnqtXWNlq3EruoVWeuwxbIqO8C6c9CC6iqp0JaSUOZ_nLDP2705x9NMaTIbn5Z0OFKYk4FG6UZAm0G1BW0MKUXqzWP0G4zPBoRZvJoXr2aRZgSYF6-myXNnuwfmbkPubWonMgPnOwCTxaGPOFqf3jipAFSrM3e15Sjr-OcpmmQ9jZacj2Qn44J_J8p_1EiWXw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18568019</pqid></control><display><type>article</type><title>Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Barfod, Lea ; Kemp, Kåre ; Hansen, Majbritt ; Kharazmi, Arsalan</creator><creatorcontrib>Barfod, Lea ; Kemp, Kåre ; Hansen, Majbritt ; Kharazmi, Arsalan</creatorcontrib><description>Licochalcone A (LicA), an oxygenated chalcone, has been shown to inhibit the growth of both parasites and bacteria. In this study, we investigated the effect of LicA and four synthetic analogues on the activity of human peripheral blood mononuclear cell proliferation and cytokine production. Four out of five chalcones tested inhibited the proliferation of lymphocytes measured by thymidine incorporation and by flow cytometry. The production of pro- and anti-inflammatory cytokines from monocytes and T cells was also inhibited by four of five chalcones. Furthermore, intracellular detection of cytokines revealed that the chalcones inhibited the production rather than the release of the cytokines. Taken together, these results indicate that LicA and some analogues may have immunomodulatory effects, and may thus be candidates not only as anti-microbial agents, but also for the treatment of other types of diseases.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/S1567-5769(01)00202-8</identifier><identifier>PMID: 11962733</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Antiparasitic Agents - pharmacology ; Biological and medical sciences ; Cell Division - drug effects ; Chalcone - analogs & derivatives ; Chalcone - isolation & purification ; Chalcone - pharmacology ; Chalcones ; Cytokines ; Cytokines - biosynthesis ; Cytokines - secretion ; Dose-Response Relationship, Drug ; Flow Cytometry ; Gene Expression Regulation - drug effects ; Glycyrrhiza - chemistry ; Glycyrrhiza glabra ; Humans ; Immunomodulators ; licochalcone A ; Lipopolysaccharides - pharmacology ; Medical sciences ; Medicine, Chinese Traditional ; Pharmacology. Drug treatments ; Phytohemagglutinins - antagonists & inhibitors ; Phytohemagglutinins - pharmacology ; Phytotherapy ; T cells ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; T-Lymphocytes - secretion ; Tetradecanoylphorbol Acetate - pharmacology</subject><ispartof>International immunopharmacology, 2002-03, Vol.2 (4), p.545-555</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-9bee48d3bd63a5ae4f6cd86393ab4f5eccda9a242b1a7bd1915b435ac23ea3733</citedby><cites>FETCH-LOGICAL-c422t-9bee48d3bd63a5ae4f6cd86393ab4f5eccda9a242b1a7bd1915b435ac23ea3733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1567-5769(01)00202-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13511596$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11962733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barfod, Lea</creatorcontrib><creatorcontrib>Kemp, Kåre</creatorcontrib><creatorcontrib>Hansen, Majbritt</creatorcontrib><creatorcontrib>Kharazmi, Arsalan</creatorcontrib><title>Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Licochalcone A (LicA), an oxygenated chalcone, has been shown to inhibit the growth of both parasites and bacteria. In this study, we investigated the effect of LicA and four synthetic analogues on the activity of human peripheral blood mononuclear cell proliferation and cytokine production. Four out of five chalcones tested inhibited the proliferation of lymphocytes measured by thymidine incorporation and by flow cytometry. The production of pro- and anti-inflammatory cytokines from monocytes and T cells was also inhibited by four of five chalcones. Furthermore, intracellular detection of cytokines revealed that the chalcones inhibited the production rather than the release of the cytokines. Taken together, these results indicate that LicA and some analogues may have immunomodulatory effects, and may thus be candidates not only as anti-microbial agents, but also for the treatment of other types of diseases.</description><subject>Antiparasitic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Chalcone - analogs & derivatives</subject><subject>Chalcone - isolation & purification</subject><subject>Chalcone - pharmacology</subject><subject>Chalcones</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - secretion</subject><subject>Dose-Response Relationship, Drug</subject><subject>Flow Cytometry</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glycyrrhiza - chemistry</subject><subject>Glycyrrhiza glabra</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>licochalcone A</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Medical sciences</subject><subject>Medicine, Chinese Traditional</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytohemagglutinins - antagonists & inhibitors</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Phytotherapy</subject><subject>T cells</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>T-Lymphocytes - secretion</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi1ExVf7E0C-UNFDqCeOneSEqlVbKiFxKD1W1sSeaA3ZGOykEv--DruIIyePPM-MXz-MnYK4BAH6629Qui5UrdsLAV-EKEVZNHvsCJq6KaAWaj_Xr8ghO07pXoh8X8EBOwRodVlLecT-rtY42DBS4n0MG75a-1wTH_zTHKK3xP249p2f-GMMg-8p4uTDyEPP77ilYUgcR7c03WxfO_Z5Cg_Lno_sQ49Dok-784T9-fH9bnVd3Nz-_LX6dlPYqiynou2IqsbJzmmJCqnqtXWNlq3EruoVWeuwxbIqO8C6c9CC6iqp0JaSUOZ_nLDP2705x9NMaTIbn5Z0OFKYk4FG6UZAm0G1BW0MKUXqzWP0G4zPBoRZvJoXr2aRZgSYF6-myXNnuwfmbkPubWonMgPnOwCTxaGPOFqf3jipAFSrM3e15Sjr-OcpmmQ9jZacj2Qn44J_J8p_1EiWXw</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Barfod, Lea</creator><creator>Kemp, Kåre</creator><creator>Hansen, Majbritt</creator><creator>Kharazmi, Arsalan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20020301</creationdate><title>Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines</title><author>Barfod, Lea ; Kemp, Kåre ; Hansen, Majbritt ; Kharazmi, Arsalan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-9bee48d3bd63a5ae4f6cd86393ab4f5eccda9a242b1a7bd1915b435ac23ea3733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antiparasitic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Chalcone - analogs & derivatives</topic><topic>Chalcone - isolation & purification</topic><topic>Chalcone - pharmacology</topic><topic>Chalcones</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - secretion</topic><topic>Dose-Response Relationship, Drug</topic><topic>Flow Cytometry</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glycyrrhiza - chemistry</topic><topic>Glycyrrhiza glabra</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>licochalcone A</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Medical sciences</topic><topic>Medicine, Chinese Traditional</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytohemagglutinins - antagonists & inhibitors</topic><topic>Phytohemagglutinins - pharmacology</topic><topic>Phytotherapy</topic><topic>T cells</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>T-Lymphocytes - secretion</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barfod, Lea</creatorcontrib><creatorcontrib>Kemp, Kåre</creatorcontrib><creatorcontrib>Hansen, Majbritt</creatorcontrib><creatorcontrib>Kharazmi, Arsalan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barfod, Lea</au><au>Kemp, Kåre</au><au>Hansen, Majbritt</au><au>Kharazmi, Arsalan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>2</volume><issue>4</issue><spage>545</spage><epage>555</epage><pages>545-555</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Licochalcone A (LicA), an oxygenated chalcone, has been shown to inhibit the growth of both parasites and bacteria. In this study, we investigated the effect of LicA and four synthetic analogues on the activity of human peripheral blood mononuclear cell proliferation and cytokine production. Four out of five chalcones tested inhibited the proliferation of lymphocytes measured by thymidine incorporation and by flow cytometry. The production of pro- and anti-inflammatory cytokines from monocytes and T cells was also inhibited by four of five chalcones. Furthermore, intracellular detection of cytokines revealed that the chalcones inhibited the production rather than the release of the cytokines. Taken together, these results indicate that LicA and some analogues may have immunomodulatory effects, and may thus be candidates not only as anti-microbial agents, but also for the treatment of other types of diseases.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11962733</pmid><doi>10.1016/S1567-5769(01)00202-8</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1567-5769 |
| ispartof | International immunopharmacology, 2002-03, Vol.2 (4), p.545-555 |
| issn | 1567-5769 1878-1705 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18568019 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antiparasitic Agents - pharmacology Biological and medical sciences Cell Division - drug effects Chalcone - analogs & derivatives Chalcone - isolation & purification Chalcone - pharmacology Chalcones Cytokines Cytokines - biosynthesis Cytokines - secretion Dose-Response Relationship, Drug Flow Cytometry Gene Expression Regulation - drug effects Glycyrrhiza - chemistry Glycyrrhiza glabra Humans Immunomodulators licochalcone A Lipopolysaccharides - pharmacology Medical sciences Medicine, Chinese Traditional Pharmacology. Drug treatments Phytohemagglutinins - antagonists & inhibitors Phytohemagglutinins - pharmacology Phytotherapy T cells T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - secretion Tetradecanoylphorbol Acetate - pharmacology |
| title | Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T22%3A00%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chalcones%20from%20Chinese%20liquorice%20inhibit%20proliferation%20of%20T%20cells%20and%20production%20of%20cytokines&rft.jtitle=International%20immunopharmacology&rft.au=Barfod,%20Lea&rft.date=2002-03-01&rft.volume=2&rft.issue=4&rft.spage=545&rft.epage=555&rft.pages=545-555&rft.issn=1567-5769&rft.eissn=1878-1705&rft_id=info:doi/10.1016/S1567-5769(01)00202-8&rft_dat=%3Cproquest_cross%3E18568019%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18568019&rft_id=info:pmid/11962733&rft_els_id=S1567576901002028&rfr_iscdi=true |