Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis

Transient receptor potential vanilloid (TRPV) channels function to maintain the dynamic balance of calcium signaling and calcium metabolism in bones. The goal of this study was to determine the potential role of TRPV6 in regulation of chondrocytes. The level of TRPV6 expression was analyzed by weste...

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Veröffentlicht in:	Journal of cellular physiology 2017-11, Vol.232 (11), p.3170-3181
Hauptverfasser:	Song, Tengfei, Ma, Jun, Guo, Lei, Yang, Peng, Zhou, Xuhui, Ye, Tianwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Arthritis Biocompatibility Bones Calcium Calcium Channels - deficiency Calcium Channels - genetics Calcium Channels - metabolism Calcium metabolism Calcium signalling Cartilage Cartilage (articular) Cartilage diseases cartilage extracellular matrix Cell growth Cell Proliferation Cells, Cultured chondrocyte Chondrocytes Chondrocytes - metabolism Chondrocytes - pathology Chondrogenesis Coding Disease Models, Animal Enzymes Extracellular matrix Extracellular Matrix - metabolism Fibrillation Genetic Predisposition to Disease Humans Knee Knee Joint - diagnostic imaging Knee Joint - metabolism Knee Joint - pathology Male Metabolism Mice, Inbred C57BL Mice, Knockout Mouse devices Osteoarthritis Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - genetics Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Pathogenesis Phenotype Proteoglycans Rats, Sprague-Dawley RNA Interference Rodents Secretion Signal Transduction Time Factors Transfection Transient receptor potential proteins TRPV Cation Channels - deficiency TRPV Cation Channels - genetics TRPV Cation Channels - metabolism TRPV6 X-Ray Microtomography
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