Acyl chain preference and inhibitor identification of Moraxella catarrhalis LpxA: Insight through crystal structure and computational studies

Lipopolysaccharide (LPS) is an important surface component and a potential virulence factor in the pathogenesis of Gram-negative bacteria. UDP-N-acetylglucosamine acyltransferase (LpxA) enzyme catalyzes the first reaction of LPS biosynthesis, reversible transfer of R-3-hydroxy-acyl moiety from donor...

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Veröffentlicht in:	International journal of biological macromolecules 2017-03, Vol.96, p.759-765
Hauptverfasser:	Pratap, Shivendra, Kesari, Pooja, Yadav, Ravi, Dev, Aditya, Narwal, Manju, Kumar, Pravindra
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - antagonists & inhibitors Acyltransferases - chemistry Acyltransferases - metabolism Crystallography, X-Ray Drug Evaluation, Preclinical Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Molecular Docking Simulation Moraxella (Branhamella) catarrhalis - enzymology Nucleotides - metabolism Protein Conformation, beta-Strand Substrate Specificity
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