Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects

[Display omitted] •Liraglutide might have anxiolytic and pro-depressant effects.•Liraglutide demonstrated neuroprotective effects and improved learning and memory.•Liraglutide protected from hippocampal neurodegeneration likely through mTOR pathway.•Liraglutide reduced hippocampal neuronal death.•Li...

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Veröffentlicht in:	Behavioural brain research 2017-03, Vol.321, p.157-169
Hauptverfasser:	Palleria, Caterina, Leo, Antonio, Andreozzi, Francesco, Citraro, Rita, Iannone, Michelangelo, Spiga, Rosangela, Sesti, Giorgio, Constanti, Andrew, De Sarro, Giovambattista, Arturi, Franco, Russo, Emilio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - drug therapy Anxiety - metabolism Anxiety - pathology Avoidance Learning - drug effects Blood Glucose - drug effects Cell Death - drug effects Cell Death - physiology Cognitive Dysfunction - metabolism Cognitive Dysfunction - pathology Cognitive Dysfunction - prevention & control Cognitive functions Depression - drug therapy Depression - metabolism Depression - pathology Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - psychology GLP-1 receptors Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Hypoglycemic Agents - pharmacology Liraglutide Liraglutide - pharmacology Male Maze Learning - drug effects Motor Activity - drug effects mTOR signaling Neurodegeneration Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology Random Allocation Rats Rats, Wistar Streptozotocin
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