Expression of X-linked Toll-like receptor 4 signaling genes in female vs. male neonates

Background: Male neonates display poorer disease prognosis and outcomes compared with females. Immune genes which exhibit higher expression in umbilical cord blood (UCB) of females may contribute to the female immune advantage during infection and inflammation. The aim of this study was to quantify...

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Veröffentlicht in:	Pediatric research 2017-05, Vol.81 (5), p.831-837
Hauptverfasser:	O’Driscoll, David N., De Santi, Chiara, McKiernan, Paul J., McEneaney, Victoria, Molloy, Eleanor J., Greene, Catherine M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/199 631/250/2502/248 631/250/262/2106/2108 692/700/1720/3186 Adult Age Factors basic-science-investigation Chromosomes, Human, X Female Females Gene expression Gestational Age Humans I-kappa B Kinase - blood I-kappa B Kinase - genetics Immune system Interleukin-1 Receptor-Associated Kinases - blood Interleukin-1 Receptor-Associated Kinases - genetics Leukocytes - metabolism Male Medicine Medicine & Public Health Newborn babies Pediatric Surgery Pediatrics Protein-Tyrosine Kinases - blood Protein-Tyrosine Kinases - genetics Ribosomal Proteins - blood Ribosomal Proteins - genetics Sex Factors Signal Transduction - genetics Term Birth Toll-Like Receptor 4 - blood Toll-Like Receptor 4 - genetics Umbilical cord Young Adult
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