What a Difference a Methyl Group Makes: The Selectivity of Monoamine Oxidase B Towards Histamine and N‐Methylhistamine

Monoamine oxidase (MAO) enzymes catalyze the degradation of a very broad range of biogenic and dietary amines including many neurotransmitters in the brain, whose imbalance is extensively linked with the biochemical pathology of various neurological disorders. Although sharing around 70 % sequence i...

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Veröffentlicht in:	Chemistry : a European journal 2017-02, Vol.23 (12), p.2915-2925
Hauptverfasser:	Maršavelski, Aleksandra, Vianello, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biocatalysis Catalytic Domain computational chemistry enzyme selectivity Histamine - chemistry Histamine - metabolism Humans hydride transfer reaction Methylhistamines - chemistry Methylhistamines - metabolism Molecular Dynamics Simulation monoamine oxidase Monoamine Oxidase - chemistry Monoamine Oxidase - metabolism Quantum Theory Thermodynamics
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