Reconstitution and Purification of Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans

Cytolethal distending toxin (CDT) has been found in various pathogenic bacterial species and causes a cell distending and a G2 arrest against eukaryotic cells. All the cdtABC genes, which encode CDT, are known to be required for the CDT activities although the CDT holotoxin structure has not been el...

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Veröffentlicht in:	Microbiology and immunology 2001-01, Vol.45 (6), p.497-506
Hauptverfasser:	Saiki, Keitarou, Konishi, Kiyoshi, Gomi, Tomoharu, Nishihara, Tatsuji, Yoshikawa, Masanosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	actinobacillus actinomycetemcomitans Aggregatibacter actinomycetemcomitans - chemistry Aggregatibacter actinomycetemcomitans - genetics Bacterial Toxins - genetics Bacterial Toxins - isolation & purification Cloning, Molecular cytolethal distending toxin Escherichia coli - genetics Escherichia coli - metabolism Gene Deletion Genetic Vectors Growth Inhibitors - isolation & purification Immunosuppressive Agents - isolation & purification Molecular Sequence Data Recombinant Proteins - biosynthesis
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