Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes'

Glycosylated 4-amino-1,8-naphthalimide derivatives possess a native glycosidic linkage that can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide as a fluorescent imaging or therapeutic agent. In vitro studies using a variety of cancer cell lines demonstrated that...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (89), p.13086-13089
Hauptverfasser:	Calatrava-Pérez, Elena, Bright, Sandra A, Achermann, Stefan, Moylan, Claire, Senge, Mathias O, Veale, Emma B, Williams, D Clive, Gunnlaugsson, Thorfinnur, Scanlan, Eoin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Chemical compounds Cleavage Derivatives Fluorescence Glycosidases Imaging Pharmacology
Online-Zugang:	Volltext
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