Synthesis and anti-proliferative activity evaluation of novel 1,4-naphthoquinones possessing pyrido[2,3-d]pyrimidine scaffolds

A series of novel 1,4-naphthoquinones possessing pyrido[2,3-d]pyrimidine scaffolds were synthesized in very good yields using one-pot condensation of 2-hydroxy-1,4-naphthoquinone, aldehydes, and 2-substituted 4,6-diaminopyrimidine. The in vitro anti-proliferative activity of these novel compounds wa...

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Veröffentlicht in:	RSC advances 2016-01, Vol.6 (78), p.73953-73958
Hauptverfasser:	Zhang, Chong, Sun, Guangfei, Peng, Qiujv, Zhu, Shiwei, Ni, Dongxuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Biotechnology Cancer Condensation In vitro testing Scaffolds Synthesis
Online-Zugang:	Volltext
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