The Current Research Status of PLGA as Drug and Gene Carrier
PLGA, poly (lactic-co-glycolic-acid), is a kind of biodegradable functional macromolecular organic compounds. PLGA, certified by the Food and Drug Administration (FDA), possesses desirable features of biocompatibility, nontoxicity and no immune response, and is being widely applied to human clinical...
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| Veröffentlicht in: | Journal of nano research 2016-07, Vol.42, p.80-91 |
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| container_title | Journal of nano research |
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| creator | Li, Guo Hua Gu, Xiang Ling Dong, Ping Xuan Cui, Shu Qin Sun, Han Wen Wu, Ji Wei Wang, Jing He Fu, Chun Hua |
| description | PLGA, poly (lactic-co-glycolic-acid), is a kind of biodegradable functional macromolecular organic compounds. PLGA, certified by the Food and Drug Administration (FDA), possesses desirable features of biocompatibility, nontoxicity and no immune response, and is being widely applied to human clinical medical research. Because of its biodegradability, simple synthetic methods, controllability of degrading rate and desirable plasticity, PLGA was applied in large quantity into the carrier materials which is to control the release in recent years, gradually propelling PLGA microsphere controlled release system to be the most ideal drug-carrier system at present. As the carrier of drug and genes, PLGA is mainly researched on its features as the carrier, synthetic methods, different surface modification methods, and the applications on different drugs, genetic treatments and genetic vaccines. |
| doi_str_mv | 10.4028/www.scientific.net/JNanoR.42.80 |
| format | Article |
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PLGA, certified by the Food and Drug Administration (FDA), possesses desirable features of biocompatibility, nontoxicity and no immune response, and is being widely applied to human clinical medical research. Because of its biodegradability, simple synthetic methods, controllability of degrading rate and desirable plasticity, PLGA was applied in large quantity into the carrier materials which is to control the release in recent years, gradually propelling PLGA microsphere controlled release system to be the most ideal drug-carrier system at present. As the carrier of drug and genes, PLGA is mainly researched on its features as the carrier, synthetic methods, different surface modification methods, and the applications on different drugs, genetic treatments and genetic vaccines.</description><identifier>ISSN: 1662-5250</identifier><identifier>ISSN: 1661-9897</identifier><identifier>EISSN: 1661-9897</identifier><identifier>DOI: 10.4028/www.scientific.net/JNanoR.42.80</identifier><language>eng</language><publisher>Zurich: Trans Tech Publications Ltd</publisher><subject>Biodegradability ; Carriers ; Control methods ; Controlled release ; Drugs ; Genes ; Genetics ; Nanostructure</subject><ispartof>Journal of nano research, 2016-07, Vol.42, p.80-91</ispartof><rights>2016 Trans Tech Publications Ltd</rights><rights>Copyright Trans Tech Publications Ltd. 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As the carrier of drug and genes, PLGA is mainly researched on its features as the carrier, synthetic methods, different surface modification methods, and the applications on different drugs, genetic treatments and genetic vaccines.</description><subject>Biodegradability</subject><subject>Carriers</subject><subject>Control methods</subject><subject>Controlled release</subject><subject>Drugs</subject><subject>Genes</subject><subject>Genetics</subject><subject>Nanostructure</subject><issn>1662-5250</issn><issn>1661-9897</issn><issn>1661-9897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkMtKAzEUQIMoWKv_EHChm5kmmckLBClVq1JUal2HNJOxU9pMTTIU_95oBcWVq9zFueeGA8AZRnmJiBhst9s8mMa62NSNyZ2Ng_sH7dppXpJcoD3Qw4zhTArJ979mklFC0SE4CmGJEKOYyR64mC0sHHXeJw-c2mC1Nwv4HHXsAmxr-DQZD6EO8Mp3r1C7Co6tSwva-8b6Y3BQ61WwJ99vH7zcXM9Gt9nkcXw3Gk4yU0gSM0qFoWVVCC0qpCmxWJZYzzkWvJYlw3NTCYaskKLiRY0pxpjSuZRcc46IqYo-ON95N75962yIat0EY1cr7WzbBYUFpQVnjBYJPf2DLtvOu_S7RCEkUCmlSNTljjK-DcHbWm18s9b-XWGkPuuqVFf91FWprtrVVSVRAiXDcGeIXrsQrVn8OvRPxwfWTIqq</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Li, Guo Hua</creator><creator>Gu, Xiang Ling</creator><creator>Dong, Ping Xuan</creator><creator>Cui, Shu Qin</creator><creator>Sun, Han Wen</creator><creator>Wu, Ji Wei</creator><creator>Wang, Jing He</creator><creator>Fu, Chun Hua</creator><general>Trans Tech Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BFMQW</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>L7M</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160701</creationdate><title>The Current Research Status of PLGA as Drug and Gene Carrier</title><author>Li, Guo Hua ; Gu, Xiang Ling ; Dong, Ping Xuan ; Cui, Shu Qin ; Sun, Han Wen ; Wu, Ji Wei ; Wang, Jing He ; Fu, Chun Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-558c54d38a8d0a52e1941ab7187f9461bcd860e898d73f1511155b997a7702cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biodegradability</topic><topic>Carriers</topic><topic>Control methods</topic><topic>Controlled release</topic><topic>Drugs</topic><topic>Genes</topic><topic>Genetics</topic><topic>Nanostructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Guo Hua</creatorcontrib><creatorcontrib>Gu, Xiang Ling</creatorcontrib><creatorcontrib>Dong, Ping Xuan</creatorcontrib><creatorcontrib>Cui, Shu Qin</creatorcontrib><creatorcontrib>Sun, Han Wen</creatorcontrib><creatorcontrib>Wu, Ji Wei</creatorcontrib><creatorcontrib>Wang, Jing He</creatorcontrib><creatorcontrib>Fu, Chun Hua</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Continental Europe Database</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of nano research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Guo Hua</au><au>Gu, Xiang Ling</au><au>Dong, Ping Xuan</au><au>Cui, Shu Qin</au><au>Sun, Han Wen</au><au>Wu, Ji Wei</au><au>Wang, Jing He</au><au>Fu, Chun Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Current Research Status of PLGA as Drug and Gene Carrier</atitle><jtitle>Journal of nano research</jtitle><date>2016-07-01</date><risdate>2016</risdate><volume>42</volume><spage>80</spage><epage>91</epage><pages>80-91</pages><issn>1662-5250</issn><issn>1661-9897</issn><eissn>1661-9897</eissn><abstract>PLGA, poly (lactic-co-glycolic-acid), is a kind of biodegradable functional macromolecular organic compounds. PLGA, certified by the Food and Drug Administration (FDA), possesses desirable features of biocompatibility, nontoxicity and no immune response, and is being widely applied to human clinical medical research. Because of its biodegradability, simple synthetic methods, controllability of degrading rate and desirable plasticity, PLGA was applied in large quantity into the carrier materials which is to control the release in recent years, gradually propelling PLGA microsphere controlled release system to be the most ideal drug-carrier system at present. As the carrier of drug and genes, PLGA is mainly researched on its features as the carrier, synthetic methods, different surface modification methods, and the applications on different drugs, genetic treatments and genetic vaccines.</abstract><cop>Zurich</cop><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/JNanoR.42.80</doi><tpages>12</tpages></addata></record> |
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| subjects | Biodegradability Carriers Control methods Controlled release Drugs Genes Genetics Nanostructure |
| title | The Current Research Status of PLGA as Drug and Gene Carrier |
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