An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers
Recent advances in the area of biosensor technology and microfluidic applications have enabled the miniaturisation of the sensing platforms. Here we describe a new integrated and fully automated lab-on-a-chip-based biosensor device prototype (MiSens) that has potential to be used for point-of-care c...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2016-11, Vol.408 (27), p.7775-7783 |
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| creator | Uludag, Yildiz Narter, Fehmi Sağlam, Erkin Köktürk, Güzin Gök, M. Yağmur Akgün, Mete Barut, Serkan Budak, Sinan |
| description | Recent advances in the area of biosensor technology and microfluidic applications have enabled the miniaturisation of the sensing platforms. Here we describe a new integrated and fully automated lab-on-a-chip-based biosensor device prototype (MiSens) that has potential to be used for point-of-care cancer biomarker testing. The key features of the device include a new biochip, a device integrated microfluidic system and real-time amperometric measurements during the flow of enzyme substrate. For ease of use, a new plug and play type sensor chip docking station has been designed. This system allows the formation of an ∼7 μL capacity flow cell on the electrode array with the necessary microfluidic and electronic connections with one move of a handle. As a case study, the developed prototype has been utilised for the detection of prostate-specific antigen (PSA) level in serum that is routinely used as a biomarker for the diagnosis of prostate cancer. The patient samples from a nearby hospital have been collected and tested using the MiSens device, and the results have been compared to the hospital results. The obtained results indicate the potential of the MiSens device as a useful tool for point-of-care testing.
Graphical abstract
Microfluidics integrated and automated electrochemical biosensor device “MiSens” has been designed and fabricated by a multidisciplinary team and utilised to detect PSA from clinical samples. |
| doi_str_mv | 10.1007/s00216-016-9879-z |
| format | Article |
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Graphical abstract
Microfluidics integrated and automated electrochemical biosensor device “MiSens” has been designed and fabricated by a multidisciplinary team and utilised to detect PSA from clinical samples.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-016-9879-z</identifier><identifier>PMID: 27562751</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analytical Chemistry ; Automation ; Automation, Laboratory ; Biochemistry ; Biological markers ; Biomarkers ; Biomarkers, Tumor - blood ; Biosensing Techniques - instrumentation ; Biosensors ; Cancer ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Devices ; Diagnosis ; Electrochemical Techniques - instrumentation ; Electrochemistry ; Electrodes ; Electronics ; Food Science ; Health aspects ; Hospitals ; Humans ; Lab-On-A-Chip Devices ; Laboratory Medicine ; Male ; Microfluidic Analytical Techniques ; Microfluidics ; Monitoring/Environmental Analysis ; Point of care testing ; Point-of-Care Systems ; Prostate cancer ; Prostate-Specific Antigen - blood ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - pathology ; Prototypes ; Research Paper ; Sensitivity and Specificity ; Sensors</subject><ispartof>Analytical and bioanalytical chemistry, 2016-11, Vol.408 (27), p.7775-7783</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c612t-ea34fc7faad9ef60d4f5bd8d9b32fb88c0ebd98ad0c1ade9862ba3bbfc7fa8ea3</citedby><cites>FETCH-LOGICAL-c612t-ea34fc7faad9ef60d4f5bd8d9b32fb88c0ebd98ad0c1ade9862ba3bbfc7fa8ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-016-9879-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-016-9879-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27562751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uludag, Yildiz</creatorcontrib><creatorcontrib>Narter, Fehmi</creatorcontrib><creatorcontrib>Sağlam, Erkin</creatorcontrib><creatorcontrib>Köktürk, Güzin</creatorcontrib><creatorcontrib>Gök, M. Yağmur</creatorcontrib><creatorcontrib>Akgün, Mete</creatorcontrib><creatorcontrib>Barut, Serkan</creatorcontrib><creatorcontrib>Budak, Sinan</creatorcontrib><title>An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Recent advances in the area of biosensor technology and microfluidic applications have enabled the miniaturisation of the sensing platforms. Here we describe a new integrated and fully automated lab-on-a-chip-based biosensor device prototype (MiSens) that has potential to be used for point-of-care cancer biomarker testing. The key features of the device include a new biochip, a device integrated microfluidic system and real-time amperometric measurements during the flow of enzyme substrate. For ease of use, a new plug and play type sensor chip docking station has been designed. This system allows the formation of an ∼7 μL capacity flow cell on the electrode array with the necessary microfluidic and electronic connections with one move of a handle. As a case study, the developed prototype has been utilised for the detection of prostate-specific antigen (PSA) level in serum that is routinely used as a biomarker for the diagnosis of prostate cancer. The patient samples from a nearby hospital have been collected and tested using the MiSens device, and the results have been compared to the hospital results. The obtained results indicate the potential of the MiSens device as a useful tool for point-of-care testing.
Graphical abstract
Microfluidics integrated and automated electrochemical biosensor device “MiSens” has been designed and fabricated by a multidisciplinary team and utilised to detect PSA from clinical samples.</description><subject>Analytical Chemistry</subject><subject>Automation</subject><subject>Automation, Laboratory</subject><subject>Biochemistry</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biosensing Techniques - instrumentation</subject><subject>Biosensors</subject><subject>Cancer</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Devices</subject><subject>Diagnosis</subject><subject>Electrochemical Techniques - instrumentation</subject><subject>Electrochemistry</subject><subject>Electrodes</subject><subject>Electronics</subject><subject>Food Science</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lab-On-A-Chip Devices</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Microfluidic Analytical Techniques</subject><subject>Microfluidics</subject><subject>Monitoring/Environmental Analysis</subject><subject>Point of care testing</subject><subject>Point-of-Care Systems</subject><subject>Prostate cancer</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prototypes</subject><subject>Research Paper</subject><subject>Sensitivity and Specificity</subject><subject>Sensors</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkl1rFTEQhhdRbK3-AG9kwRtv0ibZ3WxyeShahYI39TrkY3Kauic5JnuE9tc729PWDyyUMEmYPO-QYd6mecvoMaN0PKmUciYIxVByVOTmWXPIBJOEi4E-f7j3_KB5VesVpWyQTLxsDvg4CAx22JRVamOaYV3MDL6djCU5EUPcZdwSayrmYAI3l-wuYROdmVobc4VUc2kDRjHb6FuTfLsk4xx_QuthRknMqc2hdSY5KItqY8p3KPV18yKYqcKbu_Oo-fbp48XpZ3L-9ezL6eqcOMH4TMB0fXBjMMYrCIL6PgzWS69sx4OV0lGwXknjqWPGg5KCW9NZe6uRqD5qPuzrbkv-sYM6602sDqbJJMi7qpkchm5kYhRPQLux46rv1VPQoZO4MUTf_4Ne5V1J2DNSXDJO1aB-U2szgY4p5LkYtxTVq36kAkdJB6SO_0Ph8stUcoIQMf-XgO0FruRaCwS9LREncK0Z1Yt79N49Gt2jF_foG9S8u_vwzm7APyju7YIA3wMVn9Iayh8dPVr1FwqG0Ko</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Uludag, Yildiz</creator><creator>Narter, Fehmi</creator><creator>Sağlam, Erkin</creator><creator>Köktürk, Güzin</creator><creator>Gök, M. 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Yağmur</au><au>Akgün, Mete</au><au>Barut, Serkan</au><au>Budak, Sinan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>408</volume><issue>27</issue><spage>7775</spage><epage>7783</epage><pages>7775-7783</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Recent advances in the area of biosensor technology and microfluidic applications have enabled the miniaturisation of the sensing platforms. Here we describe a new integrated and fully automated lab-on-a-chip-based biosensor device prototype (MiSens) that has potential to be used for point-of-care cancer biomarker testing. The key features of the device include a new biochip, a device integrated microfluidic system and real-time amperometric measurements during the flow of enzyme substrate. For ease of use, a new plug and play type sensor chip docking station has been designed. This system allows the formation of an ∼7 μL capacity flow cell on the electrode array with the necessary microfluidic and electronic connections with one move of a handle. As a case study, the developed prototype has been utilised for the detection of prostate-specific antigen (PSA) level in serum that is routinely used as a biomarker for the diagnosis of prostate cancer. The patient samples from a nearby hospital have been collected and tested using the MiSens device, and the results have been compared to the hospital results. The obtained results indicate the potential of the MiSens device as a useful tool for point-of-care testing.
Graphical abstract
Microfluidics integrated and automated electrochemical biosensor device “MiSens” has been designed and fabricated by a multidisciplinary team and utilised to detect PSA from clinical samples.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27562751</pmid><doi>10.1007/s00216-016-9879-z</doi><tpages>9</tpages></addata></record> |
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| ispartof | Analytical and bioanalytical chemistry, 2016-11, Vol.408 (27), p.7775-7783 |
| issn | 1618-2642 1618-2650 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Analytical Chemistry Automation Automation, Laboratory Biochemistry Biological markers Biomarkers Biomarkers, Tumor - blood Biosensing Techniques - instrumentation Biosensors Cancer Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Devices Diagnosis Electrochemical Techniques - instrumentation Electrochemistry Electrodes Electronics Food Science Health aspects Hospitals Humans Lab-On-A-Chip Devices Laboratory Medicine Male Microfluidic Analytical Techniques Microfluidics Monitoring/Environmental Analysis Point of care testing Point-of-Care Systems Prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Prototypes Research Paper Sensitivity and Specificity Sensors |
| title | An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers |
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