Gas chromatography electrospray ionization mass spectrometry analysis of trimethylsilyl derivatives
A method based on the analysis of trimethylsilyl (TMS) derivatives by capillary gas chromatography electrospray ionization mass spectrometry (GC–ESI/MS) was proposed. To improve separation, analytes were derivatized to their TMS derivative. During ESI analysis, TMS derivatives may hydrolyze back to...
Gespeichert in:
| Veröffentlicht in: | Journal of mass spectrometry. 2016-10, Vol.51 (10), p.883-888 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 888 |
|---|---|
| container_issue | 10 |
| container_start_page | 883 |
| container_title | Journal of mass spectrometry. |
| container_volume | 51 |
| creator | Hsu, Ren-Yu Liao, Jhan-Hong Tien, Hsin-Wen Her, Guor-Rong |
| description | A method based on the analysis of trimethylsilyl (TMS) derivatives by capillary gas chromatography electrospray ionization mass spectrometry (GC–ESI/MS) was proposed. To improve separation, analytes were derivatized to their TMS derivative. During ESI analysis, TMS derivatives may hydrolyze back to their polar native form and are thus suitable for ESI analysis. Several types of analytes were studied to investigate the potential of the approach. Not all TMS derivatives hydrolyzed back to their native form as anticipated. Incomplete hydrolysis was observed for TMS‐organic acids and TMS‐nonchlorinated phenols. For TMS‐chlorophenols, the observation of only the [M − H]− ion suggested that these phenols were hydrolyzed back to their native form. For TMS‐beta agonists, the hydrolysis rate was low; therefore, the hydrolysis product was not detected. Both TMS‐chlorophenols and TMS‐beta agonists provide a sensitivity in the range of low parts per billion (0.25–5 ng/ml and 0.5–10 ng/ml respectively). Copyright © 2016 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jms.3796 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1855366364</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4216581211</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4576-dc98b02aa81b4eb54641a41245c5e3d43c76326cebd623969c3719fa11fc90093</originalsourceid><addsrcrecordid>eNqN0VtvFCEUB3BiNLZWEz-BIfHFl6nA4TI8mo1ubbb1wdsjYRjWZWV2pjBbO356md5M-tSnQzg_CJw_Qq8pOaaEsPfbLh-D0vIJOqREy0rXdf10XitZCar4AXqR85YQojWXz9EBU4orreEQuaXN2G1S39mx_5XssJmwj96Nqc9DshMO_S78tWMpuLM54zxcNzs_pgnbnY1TDhn3azymUDY3U8whThG3PoXLcu7S55fo2drG7F_d1iP0_dPHb4uTavVl-XnxYVU5LspDW6frhjBra9pw3wguObWcMi6c8NBycEoCk843rWSgpXagqF5bStdOl6_BEXp3c--Q-ou9z6PpQnY-Rrvz_T4bWgsBUoLkj6CggFDN5GOo4KABWKFvH9Btv09lRrNimlOpqCjqza3aN51vzVAGZ9Nk7kIpoLoBf0L0032fEjOHbUrYZg7bnJ59net_H_Lor-69Tb-NVKCE-Xm-NOcrqevFDzCn8A9Uuqs6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1829416715</pqid></control><display><type>article</type><title>Gas chromatography electrospray ionization mass spectrometry analysis of trimethylsilyl derivatives</title><source>Access via Wiley Online Library</source><creator>Hsu, Ren-Yu ; Liao, Jhan-Hong ; Tien, Hsin-Wen ; Her, Guor-Rong</creator><creatorcontrib>Hsu, Ren-Yu ; Liao, Jhan-Hong ; Tien, Hsin-Wen ; Her, Guor-Rong</creatorcontrib><description>A method based on the analysis of trimethylsilyl (TMS) derivatives by capillary gas chromatography electrospray ionization mass spectrometry (GC–ESI/MS) was proposed. To improve separation, analytes were derivatized to their TMS derivative. During ESI analysis, TMS derivatives may hydrolyze back to their polar native form and are thus suitable for ESI analysis. Several types of analytes were studied to investigate the potential of the approach. Not all TMS derivatives hydrolyzed back to their native form as anticipated. Incomplete hydrolysis was observed for TMS‐organic acids and TMS‐nonchlorinated phenols. For TMS‐chlorophenols, the observation of only the [M − H]− ion suggested that these phenols were hydrolyzed back to their native form. For TMS‐beta agonists, the hydrolysis rate was low; therefore, the hydrolysis product was not detected. Both TMS‐chlorophenols and TMS‐beta agonists provide a sensitivity in the range of low parts per billion (0.25–5 ng/ml and 0.5–10 ng/ml respectively). Copyright © 2016 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1076-5174</identifier><identifier>EISSN: 1096-9888</identifier><identifier>DOI: 10.1002/jms.3796</identifier><identifier>PMID: 27747993</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>beta agonist ; Derivatives ; electrospray ionization mass spectrometry ; Gas chromatography ; Hydrolysis ; Ionization ; Mass spectrometry ; organic acid ; phenol ; Phenols ; Separation ; trimethylsilyl derivative</subject><ispartof>Journal of mass spectrometry., 2016-10, Vol.51 (10), p.883-888</ispartof><rights>Copyright © 2016 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4576-dc98b02aa81b4eb54641a41245c5e3d43c76326cebd623969c3719fa11fc90093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjms.3796$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjms.3796$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27747993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, Ren-Yu</creatorcontrib><creatorcontrib>Liao, Jhan-Hong</creatorcontrib><creatorcontrib>Tien, Hsin-Wen</creatorcontrib><creatorcontrib>Her, Guor-Rong</creatorcontrib><title>Gas chromatography electrospray ionization mass spectrometry analysis of trimethylsilyl derivatives</title><title>Journal of mass spectrometry.</title><addtitle>J. Mass Spectrom</addtitle><description>A method based on the analysis of trimethylsilyl (TMS) derivatives by capillary gas chromatography electrospray ionization mass spectrometry (GC–ESI/MS) was proposed. To improve separation, analytes were derivatized to their TMS derivative. During ESI analysis, TMS derivatives may hydrolyze back to their polar native form and are thus suitable for ESI analysis. Several types of analytes were studied to investigate the potential of the approach. Not all TMS derivatives hydrolyzed back to their native form as anticipated. Incomplete hydrolysis was observed for TMS‐organic acids and TMS‐nonchlorinated phenols. For TMS‐chlorophenols, the observation of only the [M − H]− ion suggested that these phenols were hydrolyzed back to their native form. For TMS‐beta agonists, the hydrolysis rate was low; therefore, the hydrolysis product was not detected. Both TMS‐chlorophenols and TMS‐beta agonists provide a sensitivity in the range of low parts per billion (0.25–5 ng/ml and 0.5–10 ng/ml respectively). Copyright © 2016 John Wiley & Sons, Ltd.</description><subject>beta agonist</subject><subject>Derivatives</subject><subject>electrospray ionization mass spectrometry</subject><subject>Gas chromatography</subject><subject>Hydrolysis</subject><subject>Ionization</subject><subject>Mass spectrometry</subject><subject>organic acid</subject><subject>phenol</subject><subject>Phenols</subject><subject>Separation</subject><subject>trimethylsilyl derivative</subject><issn>1076-5174</issn><issn>1096-9888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqN0VtvFCEUB3BiNLZWEz-BIfHFl6nA4TI8mo1ubbb1wdsjYRjWZWV2pjBbO356md5M-tSnQzg_CJw_Qq8pOaaEsPfbLh-D0vIJOqREy0rXdf10XitZCar4AXqR85YQojWXz9EBU4orreEQuaXN2G1S39mx_5XssJmwj96Nqc9DshMO_S78tWMpuLM54zxcNzs_pgnbnY1TDhn3azymUDY3U8whThG3PoXLcu7S55fo2drG7F_d1iP0_dPHb4uTavVl-XnxYVU5LspDW6frhjBra9pw3wguObWcMi6c8NBycEoCk843rWSgpXagqF5bStdOl6_BEXp3c--Q-ou9z6PpQnY-Rrvz_T4bWgsBUoLkj6CggFDN5GOo4KABWKFvH9Btv09lRrNimlOpqCjqza3aN51vzVAGZ9Nk7kIpoLoBf0L0032fEjOHbUrYZg7bnJ59net_H_Lor-69Tb-NVKCE-Xm-NOcrqevFDzCn8A9Uuqs6</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Hsu, Ren-Yu</creator><creator>Liao, Jhan-Hong</creator><creator>Tien, Hsin-Wen</creator><creator>Her, Guor-Rong</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>NPM</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H97</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L.G</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>Gas chromatography electrospray ionization mass spectrometry analysis of trimethylsilyl derivatives</title><author>Hsu, Ren-Yu ; Liao, Jhan-Hong ; Tien, Hsin-Wen ; Her, Guor-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4576-dc98b02aa81b4eb54641a41245c5e3d43c76326cebd623969c3719fa11fc90093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>beta agonist</topic><topic>Derivatives</topic><topic>electrospray ionization mass spectrometry</topic><topic>Gas chromatography</topic><topic>Hydrolysis</topic><topic>Ionization</topic><topic>Mass spectrometry</topic><topic>organic acid</topic><topic>phenol</topic><topic>Phenols</topic><topic>Separation</topic><topic>trimethylsilyl derivative</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Ren-Yu</creatorcontrib><creatorcontrib>Liao, Jhan-Hong</creatorcontrib><creatorcontrib>Tien, Hsin-Wen</creatorcontrib><creatorcontrib>Her, Guor-Rong</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of mass spectrometry.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Ren-Yu</au><au>Liao, Jhan-Hong</au><au>Tien, Hsin-Wen</au><au>Her, Guor-Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gas chromatography electrospray ionization mass spectrometry analysis of trimethylsilyl derivatives</atitle><jtitle>Journal of mass spectrometry.</jtitle><addtitle>J. Mass Spectrom</addtitle><date>2016-10</date><risdate>2016</risdate><volume>51</volume><issue>10</issue><spage>883</spage><epage>888</epage><pages>883-888</pages><issn>1076-5174</issn><eissn>1096-9888</eissn><abstract>A method based on the analysis of trimethylsilyl (TMS) derivatives by capillary gas chromatography electrospray ionization mass spectrometry (GC–ESI/MS) was proposed. To improve separation, analytes were derivatized to their TMS derivative. During ESI analysis, TMS derivatives may hydrolyze back to their polar native form and are thus suitable for ESI analysis. Several types of analytes were studied to investigate the potential of the approach. Not all TMS derivatives hydrolyzed back to their native form as anticipated. Incomplete hydrolysis was observed for TMS‐organic acids and TMS‐nonchlorinated phenols. For TMS‐chlorophenols, the observation of only the [M − H]− ion suggested that these phenols were hydrolyzed back to their native form. For TMS‐beta agonists, the hydrolysis rate was low; therefore, the hydrolysis product was not detected. Both TMS‐chlorophenols and TMS‐beta agonists provide a sensitivity in the range of low parts per billion (0.25–5 ng/ml and 0.5–10 ng/ml respectively). Copyright © 2016 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27747993</pmid><doi>10.1002/jms.3796</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1076-5174 |
| ispartof | Journal of mass spectrometry., 2016-10, Vol.51 (10), p.883-888 |
| issn | 1076-5174 1096-9888 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1855366364 |
| source | Access via Wiley Online Library |
| subjects | beta agonist Derivatives electrospray ionization mass spectrometry Gas chromatography Hydrolysis Ionization Mass spectrometry organic acid phenol Phenols Separation trimethylsilyl derivative |
| title | Gas chromatography electrospray ionization mass spectrometry analysis of trimethylsilyl derivatives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T01%3A00%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gas%20chromatography%20electrospray%20ionization%20mass%20spectrometry%20analysis%20of%20trimethylsilyl%20derivatives&rft.jtitle=Journal%20of%20mass%20spectrometry.&rft.au=Hsu,%20Ren-Yu&rft.date=2016-10&rft.volume=51&rft.issue=10&rft.spage=883&rft.epage=888&rft.pages=883-888&rft.issn=1076-5174&rft.eissn=1096-9888&rft_id=info:doi/10.1002/jms.3796&rft_dat=%3Cproquest_pubme%3E4216581211%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1829416715&rft_id=info:pmid/27747993&rfr_iscdi=true |