A recombinant fusion protein displaying murine and human MHC class I- and II-specific epitopes protects against Leishmania amazonensis infection

[Display omitted] •A recombinant chimeric protein was developed.•It was composed by T cell epitopes specific to human and mice haplotypes.•The immunogenicity of this new protein plus saponin was evaluated in BALB/c mice.•Vaccinated animals and challenged with L. amazonensis were protected against in...

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Veröffentlicht in:	Cellular immunology 2017-03, Vol.313, p.32-42
Hauptverfasser:	Martins, Vívian T., Lage, Daniela P., Duarte, Mariana C., Carvalho, Ana Maria R.S., Costa, Lourena E., Mendes, Tiago A.O., Vale, Danniele L., Menezes-Souza, Daniel, Roatt, Bruno M., Tavares, Carlos A.P., Soto, Manuel, Coelho, Eduardo A.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - blood Bacterial Proteins - genetics CD4+ T cells CD8+ T cells Cytokines - metabolism Epitopes, T-Lymphocyte - genetics Female Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics HLA Antigens - genetics Humans Leishmania amazonensis Leishmania infantum - immunology Leishmaniasis - immunology Leishmaniasis - prevention & control Leishmaniasis Vaccines - immunology Mice Mice, Inbred BALB C Polypeptide vaccine Protein Binding Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Tegumentary leishmaniasis Th1 Cells Th1 immune response Vaccination Vaccines, Subunit - immunology
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