Morphine exposure during early life alters thermal and mechanical thresholds in rats

•Early morphine exposure triggered thermal hyperalgesia and allodynia.•Early morphine exposure decreased BDNF and NGF levels in cerebral cortex.•Early morphine exposure did not trigger any effect in interleukins 6 and 10. Morphine is an opioid analgesic used to relieve moderate-to-severe pain, inclu...

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Veröffentlicht in:	International journal of developmental neuroscience 2017-08, Vol.60 (1), p.78-85
Hauptverfasser:	Nunes, Ellen A., Medeiros, Liciane Fernandes, de Freitas, Joice Soares, Macedo, Isabel Cristina, Kuo, Jonnsin, de Souza, Andressa, Rozisky, Joanna Rippol, Caumo, Wolnei, Torres, Iraci L.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - physiology Analgesics Analgesics, Opioid - administration & dosage Animals BDNF Brain Brain - drug effects Brain - metabolism Brain stem Brain-derived neurotrophic factor Central nervous system Cerebral cortex Cytokines Dose-Response Relationship, Drug Exposure Hyperalgesia - drug therapy Hyperalgesia - physiopathology Intensive care Interleukin 10 Interleukin 6 Laboratory animals Latency Long-term effects Male Mechanical analysis Morphine Morphine - administration & dosage Narcotics Neonate rats Neonates Nerve growth factor Nerve Growth Factors - metabolism Nervous system Neurotrophic factors NGF Nociception Nociception - drug effects Nociception - physiology Opioids Pain Pain perception Pharmacology Rats Rats, Wistar Sensory Thresholds - drug effects Sensory Thresholds - physiology Temperature Thermal response Thresholds Touch
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