Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment

Despite currently available therapies, most patients diagnosed with acute myeloid leukemia (AML) die of their disease. Tumor-host interactions are critical for the survival and proliferation of cancer cells; accordingly, we hypothesize that specific targeting of the tumor microenvironment may consti...

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Veröffentlicht in:	Blood 2017-03, Vol.129 (10), p.1320-1332
Hauptverfasser:	Shafat, Manar S., Oellerich, Thomas, Mohr, Sebastian, Robinson, Stephen D., Edwards, Dylan R., Marlein, Christopher R., Piddock, Rachel E., Fenech, Matthew, Zaitseva, Lyubov, Abdul-Aziz, Amina, Turner, Jeremy, Watkins, Johnathan A., Lawes, Matthew, Bowles, Kristian M., Rushworth, Stuart A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adipocytes - pathology Adult Aged Aged, 80 and over Animals Blotting, Western Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Coculture Techniques Fatty Acid-Binding Proteins - metabolism Female Flow Cytometry Heterografts Humans Immunohistochemistry Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Male Mice Middle Aged Reverse Transcriptase Polymerase Chain Reaction Tumor Microenvironment - physiology
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