Organotypic Spheroid Culture to Mimic Radiation-Induced Salivary Hypofunction

Radiation treatment often leads to irreversible damage to normal salivary glands (SGs) because of their proximity to head and neck cancers. Optimization of the in vitro model of irradiation (IR)–induced SG damage is warranted to investigate pathophysiology and monitor treatment outcome. Here, we pre...

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Veröffentlicht in:	Journal of dental research 2017-04, Vol.96 (4), p.396-405
Hauptverfasser:	Shin, H.S., An, H.Y, Choi, J.S., Kim, H.J., Lim, J.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis Bax protein Blotting, Western Calcium influx Caspase Caspase-3 Caspase-9 Cell culture Cell Culture Techniques - methods Cell cycle Cell death Cell Survival Cytochrome Cytochrome c Dentistry Drug dosages Epithelial cells Epithelial Cells - radiation effects Fluorescent Antibody Technique Gene expression Head and neck Head and Neck Neoplasms - radiotherapy Humans I.R. radiation In Situ Nick-End Labeling Investigations Male Medical laboratories Middle Aged Morphology p53 Protein Parotid Gland - cytology Proteins Radiation Dosage Radiation therapy Real-Time Polymerase Chain Reaction Salivary gland Salivary Glands - radiation effects Secretion Signal transduction Spheroids Statistical analysis Structural proteins Structure-function relationships Sympathomimetics Tissue Engineering - methods Variance analysis α-Amylase
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