SFP1‐mediated prion‐dependent lethality is caused by increased Sup35 aggregation and alleviated by Sis1

[PSI+] is the prion form of the translation termination factor Sup35 (eRF3); [PSI+] strains display nonsense suppression. Another prion‐like element, [ISP+], is linked to antisuppression in a specific background. Transcriptional regulator Sfp1 was shown to be responsible for [ISP+] propagation. In t...

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Veröffentlicht in:	Genes to cells : devoted to molecular & cellular mechanisms 2016-12, Vol.21 (12), p.1290-1308
Hauptverfasser:	Matveenko, Andrew G., Drozdova, Polina B., Belousov, Mikhail V., Moskalenko, Svetlana E., Bondarev, Stanislav A., Barbitoff, Yury A., Nizhnikov, Anton A., Zhouravleva, Galina A.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA-Binding Proteins - metabolism Genes, Fungal Genes, Lethal HSP40 Heat-Shock Proteins - metabolism Mutation Peptide Termination Factors - metabolism Prion Proteins - genetics Prion Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism
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