Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials
Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mg supplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters...
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| Veröffentlicht in: | European journal of clinical nutrition 2016-12, Vol.70 (12), p.1354-1359 |
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| container_title | European journal of clinical nutrition |
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| creator | Veronese, N Watutantrige-Fernando, S Luchini, C Solmi, M Sartore, G Sergi, G Manzato, E Barbagallo, M Maggi, S Stubbs, B |
| description | Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mg supplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. A literature search in PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials.gov without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or at high risk of diabetes. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes with at least two studies; other outcomes were summarized descriptively. Eighteen RCTs (12 in people with diabetes and 6 in people at high risk of diabetes) were included. Compared with placebo (
n
=334), Mg treatment (
n
=336) reduced fasting plasma glucose (studies=9; SMD=−0.40; 95% CI: −0.80 to −0.00;
I
2
=77%) in people with diabetes. In conditions in people at high risk of diabetes (Mg: 226; placebo=227 participants), Mg supplementation significantly improved plasma glucose levels after a 2 h oral glucose tolerance test (three studies; SMD=−0.35; 95% CI: −0.62 to −0.07;
I
2
=0%) and demonstrated trend level reductions in HOMA-IR (homeostatic model assessment-insulin resistance; five studies; SMD=−0.57; 95% CI: −1.17 to 0.03;
I
2
=88%). Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes. |
| doi_str_mv | 10.1038/ejcn.2016.154 |
| format | Article |
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n
=334), Mg treatment (
n
=336) reduced fasting plasma glucose (studies=9; SMD=−0.40; 95% CI: −0.80 to −0.00;
I
2
=77%) in people with diabetes. In conditions in people at high risk of diabetes (Mg: 226; placebo=227 participants), Mg supplementation significantly improved plasma glucose levels after a 2 h oral glucose tolerance test (three studies; SMD=−0.35; 95% CI: −0.62 to −0.07;
I
2
=0%) and demonstrated trend level reductions in HOMA-IR (homeostatic model assessment-insulin resistance; five studies; SMD=−0.57; 95% CI: −1.17 to 0.03;
I
2
=88%). Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2016.154</identifier><identifier>PMID: 27530471</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743/137/773 ; 692/700/459/1994 ; Adult ; Aged ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Clinical Nutrition ; Clinical trials ; Confidence intervals ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - blood ; Diabetes Mellitus - etiology ; Diabetes Mellitus - therapy ; Diet ; Dietary Supplements ; Double-Blind Method ; Double-blind studies ; Epidemiology ; Fasting - blood ; Female ; Food intake ; Glucose ; Glucose metabolism ; Glucose tolerance ; Glucose Tolerance Test ; Health aspects ; Health risks ; Humans ; Insulin ; Insulin resistance ; Internal Medicine ; Magnesium ; Magnesium (Nutrient) ; Magnesium - therapeutic use ; Male ; Medicine ; Medicine & Public Health ; Meta-analysis ; Metabolic Diseases ; Metabolism ; Middle Aged ; Observations ; Parameter sensitivity ; Placebos ; Public Health ; Randomized Controlled Trials as Topic ; review ; Risk ; Risk factors</subject><ispartof>European journal of clinical nutrition, 2016-12, Vol.70 (12), p.1354-1359</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2016</rights><rights>COPYRIGHT 2016 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2016</rights><rights>Macmillan Publishers Limited, part of Springer Nature. 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-2f17e5b00e33e3c1dabaf4351fbd1d842f78f17ee705cb2dc32fc24f369239d23</citedby><cites>FETCH-LOGICAL-c557t-2f17e5b00e33e3c1dabaf4351fbd1d842f78f17ee705cb2dc32fc24f369239d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ejcn.2016.154$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ejcn.2016.154$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27530471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veronese, N</creatorcontrib><creatorcontrib>Watutantrige-Fernando, S</creatorcontrib><creatorcontrib>Luchini, C</creatorcontrib><creatorcontrib>Solmi, M</creatorcontrib><creatorcontrib>Sartore, G</creatorcontrib><creatorcontrib>Sergi, G</creatorcontrib><creatorcontrib>Manzato, E</creatorcontrib><creatorcontrib>Barbagallo, M</creatorcontrib><creatorcontrib>Maggi, S</creatorcontrib><creatorcontrib>Stubbs, B</creatorcontrib><title>Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mg supplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. A literature search in PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials.gov without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or at high risk of diabetes. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes with at least two studies; other outcomes were summarized descriptively. Eighteen RCTs (12 in people with diabetes and 6 in people at high risk of diabetes) were included. Compared with placebo (
n
=334), Mg treatment (
n
=336) reduced fasting plasma glucose (studies=9; SMD=−0.40; 95% CI: −0.80 to −0.00;
I
2
=77%) in people with diabetes. In conditions in people at high risk of diabetes (Mg: 226; placebo=227 participants), Mg supplementation significantly improved plasma glucose levels after a 2 h oral glucose tolerance test (three studies; SMD=−0.35; 95% CI: −0.62 to −0.07;
I
2
=0%) and demonstrated trend level reductions in HOMA-IR (homeostatic model assessment-insulin resistance; five studies; SMD=−0.57; 95% CI: −1.17 to 0.03;
I
2
=88%). Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes.</description><subject>692/163/2743/137/773</subject><subject>692/700/459/1994</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Clinical Nutrition</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - etiology</subject><subject>Diabetes Mellitus - therapy</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Epidemiology</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Food intake</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Internal Medicine</subject><subject>Magnesium</subject><subject>Magnesium (Nutrient)</subject><subject>Magnesium - therapeutic use</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Observations</subject><subject>Parameter sensitivity</subject><subject>Placebos</subject><subject>Public Health</subject><subject>Randomized Controlled Trials as Topic</subject><subject>review</subject><subject>Risk</subject><subject>Risk factors</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2LFDEQhhtR3HH16FUCgnjpMV_d6fa2LOsHLHjRc0inKzMZ08mYpF3Gv-UfNL2u7iqDSAoqpJ56UxRvVT0leE0w617BTvs1xaRdk4bfq1aEi7ZuWo7vVyvcN7xmGIuT6lFKO4xLUdCH1QkVDcNckFX1_cIY0BkFgya18ZDsPKE07_cOJvBZZRs8KrFxsw4J0ARZDcHZNCHr0R5CAdGVzVsUIlIZRZs-L2KjVQNkSK-RQumQMkxFSqMIXy1cIeXHa6VaeeUOyabrljAPDurB2VKNBQmT_QYj0sHnGJwr1xytculx9cCUBE9u8mn16c3Fx_N39eWHt-_Pzy5r3TQi19QQAc2AMTAGTJNRDcpw1hAzjGTsODWiWxAQuNEDHTWjRlNuWNtT1o-UnVYvf-ruY_gyQ8pyskmDc8pDmJMkXdPgjnUd-w-Ut4JSzBfV53-huzDHsockactL4K7v_0UtWgxTwbtbaqMcSOtNyFHp5Wt5xgXtCyRIoeoj1AY8ROWCB2PL8x_8-ghfzgiT1UcbXtxp2IJyeZuCmxfzpKOT6BhSimDkPtpJxYMkWC52loud5WJnWexc-Gc3W5iHCcbf9C__3o6aSslvIN5Z01HFH7YY_8A</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Veronese, N</creator><creator>Watutantrige-Fernando, S</creator><creator>Luchini, C</creator><creator>Solmi, M</creator><creator>Sartore, G</creator><creator>Sergi, G</creator><creator>Manzato, E</creator><creator>Barbagallo, M</creator><creator>Maggi, S</creator><creator>Stubbs, B</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials</title><author>Veronese, N ; Watutantrige-Fernando, S ; Luchini, C ; Solmi, M ; Sartore, G ; Sergi, G ; Manzato, E ; Barbagallo, M ; Maggi, S ; Stubbs, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-2f17e5b00e33e3c1dabaf4351fbd1d842f78f17ee705cb2dc32fc24f369239d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>692/163/2743/137/773</topic><topic>692/700/459/1994</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood Glucose - 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Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veronese, N</au><au>Watutantrige-Fernando, S</au><au>Luchini, C</au><au>Solmi, M</au><au>Sartore, G</au><au>Sergi, G</au><au>Manzato, E</au><au>Barbagallo, M</au><au>Maggi, S</au><au>Stubbs, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>70</volume><issue>12</issue><spage>1354</spage><epage>1359</epage><pages>1354-1359</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mg supplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. A literature search in PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials.gov without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or at high risk of diabetes. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes with at least two studies; other outcomes were summarized descriptively. Eighteen RCTs (12 in people with diabetes and 6 in people at high risk of diabetes) were included. Compared with placebo (
n
=334), Mg treatment (
n
=336) reduced fasting plasma glucose (studies=9; SMD=−0.40; 95% CI: −0.80 to −0.00;
I
2
=77%) in people with diabetes. In conditions in people at high risk of diabetes (Mg: 226; placebo=227 participants), Mg supplementation significantly improved plasma glucose levels after a 2 h oral glucose tolerance test (three studies; SMD=−0.35; 95% CI: −0.62 to −0.07;
I
2
=0%) and demonstrated trend level reductions in HOMA-IR (homeostatic model assessment-insulin resistance; five studies; SMD=−0.57; 95% CI: −1.17 to 0.03;
I
2
=88%). Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27530471</pmid><doi>10.1038/ejcn.2016.154</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 692/163/2743/137/773 692/700/459/1994 Adult Aged Blood Glucose - analysis Blood Glucose - metabolism Clinical Nutrition Clinical trials Confidence intervals Diabetes Diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - etiology Diabetes Mellitus - therapy Diet Dietary Supplements Double-Blind Method Double-blind studies Epidemiology Fasting - blood Female Food intake Glucose Glucose metabolism Glucose tolerance Glucose Tolerance Test Health aspects Health risks Humans Insulin Insulin resistance Internal Medicine Magnesium Magnesium (Nutrient) Magnesium - therapeutic use Male Medicine Medicine & Public Health Meta-analysis Metabolic Diseases Metabolism Middle Aged Observations Parameter sensitivity Placebos Public Health Randomized Controlled Trials as Topic review Risk Risk factors |
| title | Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials |
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