Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression

Abstract Emerging evidence suggests that metformin, an activator of AMP-activated protein kinase (AMPK), may be useful in preventing and treating pancreatic ductal adenocarcinoma (PDAC). However, whether metformin has an effect on the stromal reaction of PDAC remains unknown. In this study, we first...

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Veröffentlicht in:	Cancer letters 2017-01, Vol.385, p.225-233
Hauptverfasser:	Duan, Wanxing, Chen, Ke, Jiang, Zhengdong, Chen, Xin, Sun, Liankang, Li, Jiahui, Lei, Jianjun, Xu, Qinhong, Ma, Jiguang, Li, Xuqi, Han, Liang, Wang, Zheng, Wu, Zheng, Wang, Fengfei, Wu, Erxi, Ma, Qingyong, Ma, Zhenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated protein kinase (AMPK) AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Antimetabolites, Antineoplastic - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - enzymology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Coculture Techniques Cytokines Cytokines - metabolism Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Desmoplastic reaction Diabetes Disease Progression Enzyme Activation Enzyme Activators - pharmacology Female Fibroblasts Fibrosis Growth factors Hematology, Oncology and Palliative Medicine Hospitals Humans Kinases Medical prognosis Metformin Metformin - pharmacology Mice, Inbred BALB C Mice, Nude Mortality Neoplasm Invasiveness Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pancreatic stellate cells (PSCs) Pancreatic Stellate Cells - drug effects Pancreatic Stellate Cells - enzymology Pancreatic Stellate Cells - pathology Paracrine Communication - drug effects Pathology Phosphorylation Proteins RNA Interference Signal Transduction - drug effects Studies Time Factors Transfection Tumor Burden - drug effects Xenograft Model Antitumor Assays
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