Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction
We assessed the prognostic role of serum endocan level in patients with ST-segment elevation myocardial infarction (STEMI) and compared the results with a normal coronary angiography group. A total of 133 patients were included in the study (88 patients with STEMI and 45 patients with normal coronar...
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| Veröffentlicht in: | Angiology 2017-01, Vol.68 (1), p.46-51 |
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| creator | Kundi, Harun Balun, Ahmet Cicekcioglu, Hulya Karayigit, Orhan Topcuoglu, Canan Kilinckaya, Muhammed Fevzi Kiziltunc, Emrullah Cetin, Mustafa Ornek, Ender |
| description | We assessed the prognostic role of serum endocan level in patients with ST-segment elevation myocardial infarction (STEMI) and compared the results with a normal coronary angiography group. A total of 133 patients were included in the study (88 patients with STEMI and 45 patients with normal coronary arteries). The SYNTAX score was determined based on the baseline coronary angiogram. Multivariate logistic regression analysis indicated that endocan independently correlated with the presence of STEMI. Moreover, high-sensitivity C-reactive protein (hsCRP), peak troponin I, and left ventricular ejection fraction (LVEF) were found to be independently associated with STEMI. Endocan level correlated significantly with hsCRP and SYNTAX score. We analyzed the discriminatory capability of endocan level for the presence of STEMI using a receiver–operating characteristics curve. A cutoff endocan level of 1.7 (ng/mL) predicted the presence of STEMI with a sensitivity of 76.1% and specificity of 73.6%. In conclusion, a high endocan level on hospital admission is an independent predictor of a worse cardiovascular outcome and a high SYNTAX score in patients with STEMI. |
| doi_str_mv | 10.1177/0003319716646932 |
| format | Article |
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A total of 133 patients were included in the study (88 patients with STEMI and 45 patients with normal coronary arteries). The SYNTAX score was determined based on the baseline coronary angiogram. Multivariate logistic regression analysis indicated that endocan independently correlated with the presence of STEMI. Moreover, high-sensitivity C-reactive protein (hsCRP), peak troponin I, and left ventricular ejection fraction (LVEF) were found to be independently associated with STEMI. Endocan level correlated significantly with hsCRP and SYNTAX score. We analyzed the discriminatory capability of endocan level for the presence of STEMI using a receiver–operating characteristics curve. A cutoff endocan level of 1.7 (ng/mL) predicted the presence of STEMI with a sensitivity of 76.1% and specificity of 73.6%. In conclusion, a high endocan level on hospital admission is an independent predictor of a worse cardiovascular outcome and a high SYNTAX score in patients with STEMI.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/0003319716646932</identifier><identifier>PMID: 27178721</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Female ; Hospital Mortality ; Hospitalization - statistics & numerical data ; Humans ; Male ; Middle Aged ; Myocardial Infarction - mortality ; Neoplasm Proteins - blood ; Percutaneous Coronary Intervention - mortality ; Proteoglycans - blood ; Risk Assessment - methods ; ROC Curve ; ST Elevation Myocardial Infarction - diagnosis ; ST Elevation Myocardial Infarction - mortality ; Ventricular Function, Left - physiology</subject><ispartof>Angiology, 2017-01, Vol.68 (1), p.46-51</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-120a649b88f98ec8425a19c24fd6f1622180df4e75049e39be1b5a1ae2e1964a3</citedby><cites>FETCH-LOGICAL-c370t-120a649b88f98ec8425a19c24fd6f1622180df4e75049e39be1b5a1ae2e1964a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0003319716646932$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0003319716646932$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,778,782,21806,27911,27912,43608,43609</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27178721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kundi, Harun</creatorcontrib><creatorcontrib>Balun, Ahmet</creatorcontrib><creatorcontrib>Cicekcioglu, Hulya</creatorcontrib><creatorcontrib>Karayigit, Orhan</creatorcontrib><creatorcontrib>Topcuoglu, Canan</creatorcontrib><creatorcontrib>Kilinckaya, Muhammed Fevzi</creatorcontrib><creatorcontrib>Kiziltunc, Emrullah</creatorcontrib><creatorcontrib>Cetin, Mustafa</creatorcontrib><creatorcontrib>Ornek, Ender</creatorcontrib><title>Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction</title><title>Angiology</title><addtitle>Angiology</addtitle><description>We assessed the prognostic role of serum endocan level in patients with ST-segment elevation myocardial infarction (STEMI) and compared the results with a normal coronary angiography group. A total of 133 patients were included in the study (88 patients with STEMI and 45 patients with normal coronary arteries). The SYNTAX score was determined based on the baseline coronary angiogram. Multivariate logistic regression analysis indicated that endocan independently correlated with the presence of STEMI. Moreover, high-sensitivity C-reactive protein (hsCRP), peak troponin I, and left ventricular ejection fraction (LVEF) were found to be independently associated with STEMI. Endocan level correlated significantly with hsCRP and SYNTAX score. We analyzed the discriminatory capability of endocan level for the presence of STEMI using a receiver–operating characteristics curve. A cutoff endocan level of 1.7 (ng/mL) predicted the presence of STEMI with a sensitivity of 76.1% and specificity of 73.6%. In conclusion, a high endocan level on hospital admission is an independent predictor of a worse cardiovascular outcome and a high SYNTAX score in patients with STEMI.</description><subject>Aged</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - mortality</subject><subject>Neoplasm Proteins - blood</subject><subject>Percutaneous Coronary Intervention - mortality</subject><subject>Proteoglycans - blood</subject><subject>Risk Assessment - methods</subject><subject>ROC Curve</subject><subject>ST Elevation Myocardial Infarction - diagnosis</subject><subject>ST Elevation Myocardial Infarction - mortality</subject><subject>Ventricular Function, Left - physiology</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1v1DAQtRCILoU7J-QjlxTbcfxxrFYLXWkrKm0rjpETj4urxF7spGJ_D3-0jrZwQELiYI_mvTdPo3kIvafkglIpPxFC6ppqSYXgQtfsBVpRzUlFG8lfotVCVwt_ht7k_FDahhLxGp0xSaWSjK7Qr0s7-px9DHgTbOxNwDt4hAGP5og7wAbfZXDzgG8SWN9PMWFX3jZUVzEf_GQGfB1TKX46YhMsXscUg0lHvC82aUG3wcJP7AO-MZOHMGX8zU_f8f622sP9WAC8GeCxcGWH62NZIVlfbLfBmdQv6Fv0ypkhw7vneo7uPm9u11fV7uuX7fpyV_W1JFNFGTGC604ppxX0irPGUN0z7qxwVDBGFbGOg2wI11DrDmhXFAYYUC24qc_Rx5PvIcUfM-SpLafpYRhMgDjnlqqmIYrImv2HlAmhmvIVKTlJ-xRzTuDaQ_JjuVBLSbuk2P6dYhn58Ow-dyPYPwO_YyuC6iTI5h7ahzinUA7zb8MnbLalRQ</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Kundi, Harun</creator><creator>Balun, Ahmet</creator><creator>Cicekcioglu, Hulya</creator><creator>Karayigit, Orhan</creator><creator>Topcuoglu, Canan</creator><creator>Kilinckaya, Muhammed Fevzi</creator><creator>Kiziltunc, Emrullah</creator><creator>Cetin, Mustafa</creator><creator>Ornek, Ender</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201701</creationdate><title>Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction</title><author>Kundi, Harun ; Balun, Ahmet ; Cicekcioglu, Hulya ; Karayigit, Orhan ; Topcuoglu, Canan ; Kilinckaya, Muhammed Fevzi ; Kiziltunc, Emrullah ; Cetin, Mustafa ; Ornek, Ender</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-120a649b88f98ec8425a19c24fd6f1622180df4e75049e39be1b5a1ae2e1964a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - mortality</topic><topic>Neoplasm Proteins - blood</topic><topic>Percutaneous Coronary Intervention - mortality</topic><topic>Proteoglycans - blood</topic><topic>Risk Assessment - methods</topic><topic>ROC Curve</topic><topic>ST Elevation Myocardial Infarction - diagnosis</topic><topic>ST Elevation Myocardial Infarction - mortality</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kundi, Harun</creatorcontrib><creatorcontrib>Balun, Ahmet</creatorcontrib><creatorcontrib>Cicekcioglu, Hulya</creatorcontrib><creatorcontrib>Karayigit, Orhan</creatorcontrib><creatorcontrib>Topcuoglu, Canan</creatorcontrib><creatorcontrib>Kilinckaya, Muhammed Fevzi</creatorcontrib><creatorcontrib>Kiziltunc, Emrullah</creatorcontrib><creatorcontrib>Cetin, Mustafa</creatorcontrib><creatorcontrib>Ornek, Ender</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kundi, Harun</au><au>Balun, Ahmet</au><au>Cicekcioglu, Hulya</au><au>Karayigit, Orhan</au><au>Topcuoglu, Canan</au><au>Kilinckaya, Muhammed Fevzi</au><au>Kiziltunc, Emrullah</au><au>Cetin, Mustafa</au><au>Ornek, Ender</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>2017-01</date><risdate>2017</risdate><volume>68</volume><issue>1</issue><spage>46</spage><epage>51</epage><pages>46-51</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><abstract>We assessed the prognostic role of serum endocan level in patients with ST-segment elevation myocardial infarction (STEMI) and compared the results with a normal coronary angiography group. A total of 133 patients were included in the study (88 patients with STEMI and 45 patients with normal coronary arteries). The SYNTAX score was determined based on the baseline coronary angiogram. Multivariate logistic regression analysis indicated that endocan independently correlated with the presence of STEMI. Moreover, high-sensitivity C-reactive protein (hsCRP), peak troponin I, and left ventricular ejection fraction (LVEF) were found to be independently associated with STEMI. Endocan level correlated significantly with hsCRP and SYNTAX score. We analyzed the discriminatory capability of endocan level for the presence of STEMI using a receiver–operating characteristics curve. A cutoff endocan level of 1.7 (ng/mL) predicted the presence of STEMI with a sensitivity of 76.1% and specificity of 73.6%. In conclusion, a high endocan level on hospital admission is an independent predictor of a worse cardiovascular outcome and a high SYNTAX score in patients with STEMI.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>27178721</pmid><doi>10.1177/0003319716646932</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Female Hospital Mortality Hospitalization - statistics & numerical data Humans Male Middle Aged Myocardial Infarction - mortality Neoplasm Proteins - blood Percutaneous Coronary Intervention - mortality Proteoglycans - blood Risk Assessment - methods ROC Curve ST Elevation Myocardial Infarction - diagnosis ST Elevation Myocardial Infarction - mortality Ventricular Function, Left - physiology |
| title | Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction |
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