Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients

Background: No molecular marker can monitor disease progression and treatment efficacy in multiple sclerosis (MS). Circulating microparticles represent a potential snapshot of disease activity at the blood brain barrier. Objectives and methods: To profile plasma microparticles by flow cytometry in M...

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Veröffentlicht in:	Multiple sclerosis 2016-12, Vol.22 (14), p.1883-1887
Hauptverfasser:	Zinger, Anna, Latham, Sharissa L, Combes, Valery, Byrne, Scott, Barnett, Michael H, Hawke, Simon, Grau, Georges E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult B-Lymphocytes Cell-Derived Microparticles Endothelial Cells Endothelium, Vascular - drug effects Female Fingolimod Hydrochloride - administration & dosage Fingolimod Hydrochloride - pharmacology Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacology Male Middle Aged Multiple Sclerosis - blood Multiple Sclerosis - drug therapy
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