Genetic determinants and postorthodontic external apical root resorption in Czech children
Objective Genes, involved in the modulation of inflammatory response and bone remodeling, play a role in the development of postorthodontic external apical root resorption (EARR). The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (SNPs) in interl...
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| Veröffentlicht in: | Oral diseases 2017-01, Vol.23 (1), p.29-35 |
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| creator | Borilova Linhartova, P Cernochova, P Kastovsky, J Vrankova, Z Sirotkova, M Izakovicova Holla, L |
| description | Objective
Genes, involved in the modulation of inflammatory response and bone remodeling, play a role in the development of postorthodontic external apical root resorption (EARR). The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (SNPs) in interleukin‐17A (IL‐17), osteopontin (SPP1), purinoreceptor P2X7 (P2RX7), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) genes and EARR in children after orthodontic treatment.
Subjects and Methods
This case–control study comprised 99 orthodontically treated patients (69 controls and 30 subjects with EARR). Genotype determinations of rs2275913, rs11730582, rs9138, rs208294, rs1718119, rs3102735, and rs2073618 were based on polymerase chain reaction using 5′ nuclease TaqMan® assays.
Results
While no significant differences were observed in allele or genotype frequencies of all seven studied SNPs, specific haplotype of P2RX7 (rs208294 and rs1718119) modified the risk of EARR development (P |
| doi_str_mv | 10.1111/odi.12564 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1855076069</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1847883342</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3864-98721765e85128c6370bffeec93362c4f708a861af4612bd330bb9d8bdd2c7f53</originalsourceid><addsrcrecordid>eNqN0U9LHDEYBvBQKnXVHvoFykAv7WHW_E_mWLZWhQUvCuJlyCTvsJHZZJrMYu2nN-uuPQiCbw5vDj8eeHkQ-kLwnJQ5jc7PCRWSf0AzIjGpsabiY_kzwWtB2e0hOsr5HmOiGkY_oUOqeMMIpzN0dw4BJm8rBxOktQ8mTLkywVVjzFNM0yq6GLYA_hYQzFCZ0duyUoxTlSDHNE4-hsqHavEP7KqyKz-4BOEEHfRmyPB5v4_Rze-z68VFvbw6v1z8XNaWacnrRitKlBSgBaHaSqZw1_cAtmFMUst7hbXRkpieS0I7xxjuusbpzjlqVS_YMfq-yx1T_LOBPLVrny0MgwkQN7klWgisJJbNOyhXWjPGaaHfXtH7uNne_6zKw1zLon7slE0x5wR9Oya_NumxJbjddtOWbtrnbor9uk_cdGtw_-VLGQWc7sCDH-Dx7aT26tflLvIJDruYAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1848480486</pqid></control><display><type>article</type><title>Genetic determinants and postorthodontic external apical root resorption in Czech children</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Borilova Linhartova, P ; Cernochova, P ; Kastovsky, J ; Vrankova, Z ; Sirotkova, M ; Izakovicova Holla, L</creator><creatorcontrib>Borilova Linhartova, P ; Cernochova, P ; Kastovsky, J ; Vrankova, Z ; Sirotkova, M ; Izakovicova Holla, L</creatorcontrib><description>Objective
Genes, involved in the modulation of inflammatory response and bone remodeling, play a role in the development of postorthodontic external apical root resorption (EARR). The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (SNPs) in interleukin‐17A (IL‐17), osteopontin (SPP1), purinoreceptor P2X7 (P2RX7), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) genes and EARR in children after orthodontic treatment.
Subjects and Methods
This case–control study comprised 99 orthodontically treated patients (69 controls and 30 subjects with EARR). Genotype determinations of rs2275913, rs11730582, rs9138, rs208294, rs1718119, rs3102735, and rs2073618 were based on polymerase chain reaction using 5′ nuclease TaqMan® assays.
Results
While no significant differences were observed in allele or genotype frequencies of all seven studied SNPs, specific haplotype of P2RX7 (rs208294 and rs1718119) modified the risk of EARR development (P < 0.05). In addition, the length of treatment with a fixed orthodontic appliance positively correlated with the presence of EARR (P < 0.05).
Conclusions
Although the effect of individual SNPs studied on the EARR development was not confirmed in the Czech population, complex analysis suggested that variability in the P2RX7 gene and the length of orthodontic treatment may be important factors contributing to the etiopathogenesis of postorthodontic EARR.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.12564</identifier><identifier>PMID: 27493142</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Case-Control Studies ; Children & youth ; Czech Republic ; Dentistry ; Female ; Gene Frequency - genetics ; gene polymorphism ; Genetic Predisposition to Disease - genetics ; Genetics ; Humans ; Interleukin-17 - genetics ; Interleukin-17 - physiology ; Male ; orthodontic treatment ; Orthodontics ; Orthodontics, Corrective - adverse effects ; Osteopontin - genetics ; Osteopontin - physiology ; Osteoprotegerin - genetics ; Osteoprotegerin - physiology ; Polymorphism, Single Nucleotide - genetics ; Receptors, Purinergic P2X7 - genetics ; Receptors, Purinergic P2X7 - physiology ; root resorption ; Root Resorption - etiology ; Root Resorption - genetics</subject><ispartof>Oral diseases, 2017-01, Vol.23 (1), p.29-35</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3864-98721765e85128c6370bffeec93362c4f708a861af4612bd330bb9d8bdd2c7f53</citedby><cites>FETCH-LOGICAL-c3864-98721765e85128c6370bffeec93362c4f708a861af4612bd330bb9d8bdd2c7f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.12564$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.12564$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27493142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borilova Linhartova, P</creatorcontrib><creatorcontrib>Cernochova, P</creatorcontrib><creatorcontrib>Kastovsky, J</creatorcontrib><creatorcontrib>Vrankova, Z</creatorcontrib><creatorcontrib>Sirotkova, M</creatorcontrib><creatorcontrib>Izakovicova Holla, L</creatorcontrib><title>Genetic determinants and postorthodontic external apical root resorption in Czech children</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
Genes, involved in the modulation of inflammatory response and bone remodeling, play a role in the development of postorthodontic external apical root resorption (EARR). The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (SNPs) in interleukin‐17A (IL‐17), osteopontin (SPP1), purinoreceptor P2X7 (P2RX7), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) genes and EARR in children after orthodontic treatment.
Subjects and Methods
This case–control study comprised 99 orthodontically treated patients (69 controls and 30 subjects with EARR). Genotype determinations of rs2275913, rs11730582, rs9138, rs208294, rs1718119, rs3102735, and rs2073618 were based on polymerase chain reaction using 5′ nuclease TaqMan® assays.
Results
While no significant differences were observed in allele or genotype frequencies of all seven studied SNPs, specific haplotype of P2RX7 (rs208294 and rs1718119) modified the risk of EARR development (P < 0.05). In addition, the length of treatment with a fixed orthodontic appliance positively correlated with the presence of EARR (P < 0.05).
Conclusions
Although the effect of individual SNPs studied on the EARR development was not confirmed in the Czech population, complex analysis suggested that variability in the P2RX7 gene and the length of orthodontic treatment may be important factors contributing to the etiopathogenesis of postorthodontic EARR.</description><subject>Adolescent</subject><subject>Case-Control Studies</subject><subject>Children & youth</subject><subject>Czech Republic</subject><subject>Dentistry</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>gene polymorphism</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetics</subject><subject>Humans</subject><subject>Interleukin-17 - genetics</subject><subject>Interleukin-17 - physiology</subject><subject>Male</subject><subject>orthodontic treatment</subject><subject>Orthodontics</subject><subject>Orthodontics, Corrective - adverse effects</subject><subject>Osteopontin - genetics</subject><subject>Osteopontin - physiology</subject><subject>Osteoprotegerin - genetics</subject><subject>Osteoprotegerin - physiology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Receptors, Purinergic P2X7 - genetics</subject><subject>Receptors, Purinergic P2X7 - physiology</subject><subject>root resorption</subject><subject>Root Resorption - etiology</subject><subject>Root Resorption - genetics</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U9LHDEYBvBQKnXVHvoFykAv7WHW_E_mWLZWhQUvCuJlyCTvsJHZZJrMYu2nN-uuPQiCbw5vDj8eeHkQ-kLwnJQ5jc7PCRWSf0AzIjGpsabiY_kzwWtB2e0hOsr5HmOiGkY_oUOqeMMIpzN0dw4BJm8rBxOktQ8mTLkywVVjzFNM0yq6GLYA_hYQzFCZ0duyUoxTlSDHNE4-hsqHavEP7KqyKz-4BOEEHfRmyPB5v4_Rze-z68VFvbw6v1z8XNaWacnrRitKlBSgBaHaSqZw1_cAtmFMUst7hbXRkpieS0I7xxjuusbpzjlqVS_YMfq-yx1T_LOBPLVrny0MgwkQN7klWgisJJbNOyhXWjPGaaHfXtH7uNne_6zKw1zLon7slE0x5wR9Oya_NumxJbjddtOWbtrnbor9uk_cdGtw_-VLGQWc7sCDH-Dx7aT26tflLvIJDruYAA</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Borilova Linhartova, P</creator><creator>Cernochova, P</creator><creator>Kastovsky, J</creator><creator>Vrankova, Z</creator><creator>Sirotkova, M</creator><creator>Izakovicova Holla, L</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201701</creationdate><title>Genetic determinants and postorthodontic external apical root resorption in Czech children</title><author>Borilova Linhartova, P ; Cernochova, P ; Kastovsky, J ; Vrankova, Z ; Sirotkova, M ; Izakovicova Holla, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3864-98721765e85128c6370bffeec93362c4f708a861af4612bd330bb9d8bdd2c7f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Case-Control Studies</topic><topic>Children & youth</topic><topic>Czech Republic</topic><topic>Dentistry</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>gene polymorphism</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetics</topic><topic>Humans</topic><topic>Interleukin-17 - genetics</topic><topic>Interleukin-17 - physiology</topic><topic>Male</topic><topic>orthodontic treatment</topic><topic>Orthodontics</topic><topic>Orthodontics, Corrective - adverse effects</topic><topic>Osteopontin - genetics</topic><topic>Osteopontin - physiology</topic><topic>Osteoprotegerin - genetics</topic><topic>Osteoprotegerin - physiology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Receptors, Purinergic P2X7 - genetics</topic><topic>Receptors, Purinergic P2X7 - physiology</topic><topic>root resorption</topic><topic>Root Resorption - etiology</topic><topic>Root Resorption - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borilova Linhartova, P</creatorcontrib><creatorcontrib>Cernochova, P</creatorcontrib><creatorcontrib>Kastovsky, J</creatorcontrib><creatorcontrib>Vrankova, Z</creatorcontrib><creatorcontrib>Sirotkova, M</creatorcontrib><creatorcontrib>Izakovicova Holla, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borilova Linhartova, P</au><au>Cernochova, P</au><au>Kastovsky, J</au><au>Vrankova, Z</au><au>Sirotkova, M</au><au>Izakovicova Holla, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic determinants and postorthodontic external apical root resorption in Czech children</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2017-01</date><risdate>2017</risdate><volume>23</volume><issue>1</issue><spage>29</spage><epage>35</epage><pages>29-35</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objective
Genes, involved in the modulation of inflammatory response and bone remodeling, play a role in the development of postorthodontic external apical root resorption (EARR). The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (SNPs) in interleukin‐17A (IL‐17), osteopontin (SPP1), purinoreceptor P2X7 (P2RX7), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) genes and EARR in children after orthodontic treatment.
Subjects and Methods
This case–control study comprised 99 orthodontically treated patients (69 controls and 30 subjects with EARR). Genotype determinations of rs2275913, rs11730582, rs9138, rs208294, rs1718119, rs3102735, and rs2073618 were based on polymerase chain reaction using 5′ nuclease TaqMan® assays.
Results
While no significant differences were observed in allele or genotype frequencies of all seven studied SNPs, specific haplotype of P2RX7 (rs208294 and rs1718119) modified the risk of EARR development (P < 0.05). In addition, the length of treatment with a fixed orthodontic appliance positively correlated with the presence of EARR (P < 0.05).
Conclusions
Although the effect of individual SNPs studied on the EARR development was not confirmed in the Czech population, complex analysis suggested that variability in the P2RX7 gene and the length of orthodontic treatment may be important factors contributing to the etiopathogenesis of postorthodontic EARR.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27493142</pmid><doi>10.1111/odi.12564</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Case-Control Studies Children & youth Czech Republic Dentistry Female Gene Frequency - genetics gene polymorphism Genetic Predisposition to Disease - genetics Genetics Humans Interleukin-17 - genetics Interleukin-17 - physiology Male orthodontic treatment Orthodontics Orthodontics, Corrective - adverse effects Osteopontin - genetics Osteopontin - physiology Osteoprotegerin - genetics Osteoprotegerin - physiology Polymorphism, Single Nucleotide - genetics Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - physiology root resorption Root Resorption - etiology Root Resorption - genetics |
| title | Genetic determinants and postorthodontic external apical root resorption in Czech children |
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