Circulating naive and memory CD4 super(+) T cells and metabolic syndrome in patients with systemic lupus erythematosus: data from a primarily Mestizo population

Objective. The aim of this study was to determine whether the proportions of naive and memory CD4 super(+) T cell are independently associated with the metabolic syndrome (MetS) in patients with SLE.Methods. This cross-sectional study was conducted in SLE patients seen at our rheumatology department...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 2015-07, Vol.54 (7), p.1302-1307
Hauptverfasser: Ugarte-Gil, Manuel F, Sanchez-Zuniga, Cesar, Gamboa-Cardenas, Rocio V, Aliaga-Zamudio, Madeley, Zevallos, Francisco, Tineo-Pozo, Giannina, Cucho-Venegas, Jorge M, Mosqueira-Riveros, Ana, Perich-Campos, Risto A, Alfaro-Lozano, Jose L, Medina, Mariela, Rodriguez-Bellido, Zoila, Alarcon, Graciela S, Pastor-Asurza, Cesar A
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Sprache:eng
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Zusammenfassung:Objective. The aim of this study was to determine whether the proportions of naive and memory CD4 super(+) T cell are independently associated with the metabolic syndrome (MetS) in patients with SLE.Methods. This cross-sectional study was conducted in SLE patients seen at our rheumatology department between September 2013 and April 2014. CD4 super(+) T cell subpopulations were examined by flow cytometry. The association of MetS and CD4 super(+) T cell subpopulations was examined by Mann-Whitney U-test and by multivariable analysis, adjusting for all possible confounding variables.Results. One hundred and seventeen patients were evaluated. Their mean age was 44.6 years (s.d. 12.6), 109 (93.2%) were female and all patients were Mestizo (mixed Caucasian and Amerindian ancestry). Fifty-two patients (44.4%) presented with MetS. Disease duration was 7.6 years (s.d. 6.8). The percentage of naive CD4 super(+) T cells was 25.0 (s.d. 12.7) and memory CD4 super(+) T cells was 66.7 (s.d. 13.2) and the memory:naive CD4 super(+) T cell ratio was 4.3 (s.d. 5.6). In multivariable analysis, the percentage of naive CD4 super(+) T cells was negatively associated with the presence of MetS [odds ratio (OR) 0.959 (95% CI 0.923, 0.997), P = 0.033], whereas the percentage of memory CD4 super(+)T cells and the memory:naive CD4 super(+) T cell ratio were positively associated with its presence [OR 1.040 (95% CI 1.003, 1.078), P = 0.031 and OR 1.238 (95% CI 1.041, 1.472), P = 0.016, respectively].Conclusion. In the SLE patients studied, a lower percentage of naive CD4 super(+) T cells, a higher percentage of memory CD4 super(+) T cells and the memory:naive CD4 super(+) T cell ratio were independently associated with the presence of MetS. This association could reflect the impact of immunosenescence among SLE patients with cardiovascular morbidity.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keu434