Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil
Summary Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross‐sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study s...
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| Veröffentlicht in: | Mycoses 2017-01, Vol.60 (1), p.59-65 |
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| creator | Silva, Thaísa C. Treméa, Carolina M. Zara, Ana Laura S. A. Mendonça, Ana Flávia Godoy, Cássia S. M. Costa, Carolina R. Souza, Lúcia K. H. Silva, Maria R. R. |
| description | Summary
Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross‐sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory‐confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84.2%, cough in 63.4%, weight loss in 63.1%, diarrhoea in 44.8% and skin manifestations in 27.6% of patients. In the overall cohort, the CD4 counts were low, but not significantly different in survivors and non‐survivors. Higher levels of urea and lower levels of haemoglobin and platelets were observed in non‐survivor patients ( |
| doi_str_mv | 10.1111/myc.12551 |
| format | Article |
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Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross‐sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory‐confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84.2%, cough in 63.4%, weight loss in 63.1%, diarrhoea in 44.8% and skin manifestations in 27.6% of patients. In the overall cohort, the CD4 counts were low, but not significantly different in survivors and non‐survivors. Higher levels of urea and lower levels of haemoglobin and platelets were observed in non‐survivor patients (<.05). The global lethality was 71.3% (196/275). The results with high prevalence and lethality highlight the need to adopt measures to facilitate early diagnosis, proper treatment and improved prognosis.</description><identifier>ISSN: 0933-7407</identifier><identifier>EISSN: 1439-0507</identifier><identifier>DOI: 10.1111/myc.12551</identifier><identifier>PMID: 27625302</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - epidemiology ; Acquired Immunodeficiency Syndrome - mortality ; Adolescent ; Adult ; Aged ; AIDS ; Antifungal Agents - therapeutic use ; Brazil - epidemiology ; CD4 antigen ; CD4 Lymphocyte Count ; Child ; Cohort Studies ; Cough ; Cross-Sectional Studies ; Data processing ; Diarrhea ; Female ; Fever ; Hemoglobin ; Hemoglobins - analysis ; Histoplasmosis ; Histoplasmosis - drug therapy ; Histoplasmosis - epidemiology ; Histoplasmosis - mortality ; Humans ; Lethality ; Male ; Medical Records ; Middle Aged ; Mycosis ; Opportunistic Infections - drug therapy ; Opportunistic Infections - epidemiology ; Opportunistic Infections - mortality ; Platelet Count ; Platelets ; Prevalence ; Public health ; Retrospective Studies ; Skin ; Tertiary Care Centers - statistics & numerical data ; Urea ; Urea - analysis ; Young Adult</subject><ispartof>Mycoses, 2017-01, Vol.60 (1), p.59-65</ispartof><rights>2016 Blackwell Verlag GmbH</rights><rights>2016 Blackwell Verlag GmbH.</rights><rights>2017 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3861-ae037602a5b189258d1f46ae2f5f1855bd490c6c129709e7b4383d2dd6dde30a3</citedby><cites>FETCH-LOGICAL-c3861-ae037602a5b189258d1f46ae2f5f1855bd490c6c129709e7b4383d2dd6dde30a3</cites><orcidid>0000-0002-9595-3319</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmyc.12551$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmyc.12551$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27625302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Thaísa C.</creatorcontrib><creatorcontrib>Treméa, Carolina M.</creatorcontrib><creatorcontrib>Zara, Ana Laura S. A.</creatorcontrib><creatorcontrib>Mendonça, Ana Flávia</creatorcontrib><creatorcontrib>Godoy, Cássia S. M.</creatorcontrib><creatorcontrib>Costa, Carolina R.</creatorcontrib><creatorcontrib>Souza, Lúcia K. H.</creatorcontrib><creatorcontrib>Silva, Maria R. R.</creatorcontrib><title>Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil</title><title>Mycoses</title><addtitle>Mycoses</addtitle><description>Summary
Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross‐sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory‐confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84.2%, cough in 63.4%, weight loss in 63.1%, diarrhoea in 44.8% and skin manifestations in 27.6% of patients. In the overall cohort, the CD4 counts were low, but not significantly different in survivors and non‐survivors. Higher levels of urea and lower levels of haemoglobin and platelets were observed in non‐survivor patients (<.05). The global lethality was 71.3% (196/275). The results with high prevalence and lethality highlight the need to adopt measures to facilitate early diagnosis, proper treatment and improved prognosis.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - epidemiology</subject><subject>Acquired Immunodeficiency Syndrome - mortality</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Brazil - epidemiology</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Cough</subject><subject>Cross-Sectional Studies</subject><subject>Data processing</subject><subject>Diarrhea</subject><subject>Female</subject><subject>Fever</subject><subject>Hemoglobin</subject><subject>Hemoglobins - analysis</subject><subject>Histoplasmosis</subject><subject>Histoplasmosis - drug therapy</subject><subject>Histoplasmosis - epidemiology</subject><subject>Histoplasmosis - mortality</subject><subject>Humans</subject><subject>Lethality</subject><subject>Male</subject><subject>Medical Records</subject><subject>Middle Aged</subject><subject>Mycosis</subject><subject>Opportunistic Infections - drug therapy</subject><subject>Opportunistic Infections - epidemiology</subject><subject>Opportunistic Infections - mortality</subject><subject>Platelet Count</subject><subject>Platelets</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Retrospective Studies</subject><subject>Skin</subject><subject>Tertiary Care Centers - statistics & numerical data</subject><subject>Urea</subject><subject>Urea - analysis</subject><subject>Young Adult</subject><issn>0933-7407</issn><issn>1439-0507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctOGzEUQK0KVELaRX8AWWIDiwE_xq8lBChIIKo-Fl1ZzvgOMfKMw3hCFL6-k4R2UQkJb-7m3KNrHYS-UHJCh3farKoTyoSgH9CIltwURBC1g0bEcF6okqg9tJ_zIyFUGSY_oj2mJBOcsBHy3zp4dhHaCrBrPY7Qz1wM_Qq7JrUPeO76AG2f8TL0MzwLuU_z6HKTcsibhbObix84tLifAb4Lfgm5x9_hIaQWpxqfd-4lxE9ot3Yxw-fXOUa_ri5_Tq6L2_uvN5Oz26LiWtLCAeFKEubElGrDhPa0LqUDVouaaiGmvjSkkhVlRhEDalpyzT3zXnoPnDg-Rkdb77xLT4vhEtuEXEGMroW0yHYtIYprRd-BlpLLUis9oIf_oY9p0bXDRyw1jAiumVlTx1uq6lLOHdR23oXGdStLiV1XskMlu6k0sAevxsW0Af-P_JtlAE63wDJEWL1tsne_J1vlH81Emjo</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Silva, Thaísa C.</creator><creator>Treméa, Carolina M.</creator><creator>Zara, Ana Laura S. A.</creator><creator>Mendonça, Ana Flávia</creator><creator>Godoy, Cássia S. M.</creator><creator>Costa, Carolina R.</creator><creator>Souza, Lúcia K. H.</creator><creator>Silva, Maria R. R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0002-9595-3319</orcidid></search><sort><creationdate>201701</creationdate><title>Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil</title><author>Silva, Thaísa C. ; Treméa, Carolina M. ; Zara, Ana Laura S. A. ; Mendonça, Ana Flávia ; Godoy, Cássia S. M. ; Costa, Carolina R. ; Souza, Lúcia K. H. ; Silva, Maria R. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3861-ae037602a5b189258d1f46ae2f5f1855bd490c6c129709e7b4383d2dd6dde30a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Acquired Immunodeficiency Syndrome - epidemiology</topic><topic>Acquired Immunodeficiency Syndrome - mortality</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Brazil - epidemiology</topic><topic>CD4 antigen</topic><topic>CD4 Lymphocyte Count</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Cough</topic><topic>Cross-Sectional Studies</topic><topic>Data processing</topic><topic>Diarrhea</topic><topic>Female</topic><topic>Fever</topic><topic>Hemoglobin</topic><topic>Hemoglobins - analysis</topic><topic>Histoplasmosis</topic><topic>Histoplasmosis - drug therapy</topic><topic>Histoplasmosis - epidemiology</topic><topic>Histoplasmosis - mortality</topic><topic>Humans</topic><topic>Lethality</topic><topic>Male</topic><topic>Medical Records</topic><topic>Middle Aged</topic><topic>Mycosis</topic><topic>Opportunistic Infections - drug therapy</topic><topic>Opportunistic Infections - epidemiology</topic><topic>Opportunistic Infections - mortality</topic><topic>Platelet Count</topic><topic>Platelets</topic><topic>Prevalence</topic><topic>Public health</topic><topic>Retrospective Studies</topic><topic>Skin</topic><topic>Tertiary Care Centers - statistics & numerical data</topic><topic>Urea</topic><topic>Urea - analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Thaísa C.</creatorcontrib><creatorcontrib>Treméa, Carolina M.</creatorcontrib><creatorcontrib>Zara, Ana Laura S. A.</creatorcontrib><creatorcontrib>Mendonça, Ana Flávia</creatorcontrib><creatorcontrib>Godoy, Cássia S. M.</creatorcontrib><creatorcontrib>Costa, Carolina R.</creatorcontrib><creatorcontrib>Souza, Lúcia K. H.</creatorcontrib><creatorcontrib>Silva, Maria R. R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Mycoses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Thaísa C.</au><au>Treméa, Carolina M.</au><au>Zara, Ana Laura S. A.</au><au>Mendonça, Ana Flávia</au><au>Godoy, Cássia S. M.</au><au>Costa, Carolina R.</au><au>Souza, Lúcia K. H.</au><au>Silva, Maria R. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil</atitle><jtitle>Mycoses</jtitle><addtitle>Mycoses</addtitle><date>2017-01</date><risdate>2017</risdate><volume>60</volume><issue>1</issue><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>0933-7407</issn><eissn>1439-0507</eissn><abstract>Summary
Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross‐sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory‐confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84.2%, cough in 63.4%, weight loss in 63.1%, diarrhoea in 44.8% and skin manifestations in 27.6% of patients. In the overall cohort, the CD4 counts were low, but not significantly different in survivors and non‐survivors. Higher levels of urea and lower levels of haemoglobin and platelets were observed in non‐survivor patients (<.05). The global lethality was 71.3% (196/275). The results with high prevalence and lethality highlight the need to adopt measures to facilitate early diagnosis, proper treatment and improved prognosis.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27625302</pmid><doi>10.1111/myc.12551</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9595-3319</orcidid></addata></record> |
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| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - epidemiology Acquired Immunodeficiency Syndrome - mortality Adolescent Adult Aged AIDS Antifungal Agents - therapeutic use Brazil - epidemiology CD4 antigen CD4 Lymphocyte Count Child Cohort Studies Cough Cross-Sectional Studies Data processing Diarrhea Female Fever Hemoglobin Hemoglobins - analysis Histoplasmosis Histoplasmosis - drug therapy Histoplasmosis - epidemiology Histoplasmosis - mortality Humans Lethality Male Medical Records Middle Aged Mycosis Opportunistic Infections - drug therapy Opportunistic Infections - epidemiology Opportunistic Infections - mortality Platelet Count Platelets Prevalence Public health Retrospective Studies Skin Tertiary Care Centers - statistics & numerical data Urea Urea - analysis Young Adult |
| title | Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil |
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