Age-related alterations in human neocortical plasticity

Age-related alterations in human neocortical plasticity

Highlights • An in vivo comparison of sensory plasticity between young and older adults. • There was no LTP- like enhancement of the visually evoked potential for older adults. • Both age groups showed an LTD- like shift after repeated low frequency stimulation. • Results suggest a shift in the thre...

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Veröffentlicht in:Brain research bulletin 2017-04, Vol.130, p.53-59
Hauptverfasser: Spriggs, M.J, Cadwallader, C.J, Hamm, J.P, Tippett, L.J, Kirk, I.J
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Ageing
Aging
EEG
Electroencephalography
Evoked Potentials, Visual
Female
Humans
Long-Term Potentiation
LTD
LTP
Male
Neocortex - physiology
Neocortical plasticity
Neurology
Neuronal Plasticity
Photic Stimulation
VEP
Young Adult
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Beschreibung
Zusammenfassung:Highlights • An in vivo comparison of sensory plasticity between young and older adults. • There was no LTP- like enhancement of the visually evoked potential for older adults. • Both age groups showed an LTD- like shift after repeated low frequency stimulation. • Results suggest a shift in the threshold for LTP, but not LTD, with age
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.12.015