Kaempferol slows intervertebral disc degeneration by modifying LPS-induced osteogenesis/adipogenesis imbalance and inflammation response in BMSCs

Intervertebral disc (IVD) degeneration is a common disease that represents a significant cause of socio-economic problems. Bone marrow-derived mesenchymal stem cells (BMSCs) are a potential autologous stem cell source for the nucleus pulposus regeneration. Kaempferol has been reported to exert prote...

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Veröffentlicht in:	International immunopharmacology 2017-02, Vol.43, p.236-242
Hauptverfasser:	Zhu, Jun, Tang, Haoyu, Zhang, Zhenhua, Zhang, Yong, Qiu, Chengfeng, Zhang, Ling, Huang, Pinge, Li, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis Adipogenesis - drug effects Aggrecan Animals Apoptosis Apoptosis - drug effects Autografts Biocompatibility Biomedical materials BMSCs Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - physiology Carnitine Carnitine O-Palmitoyltransferase - metabolism Catabolism Cell Differentiation - drug effects Cell proliferation Cell Proliferation - drug effects Cells, Cultured Collagen (type II) Collagenase 3 Cytokines Cytokines - metabolism Cytotoxicity Degeneration Differentiation Enzymes Gene expression Genes Humans Inflammation Inflammation - drug therapy Inflammation Mediators - metabolism Interleukin 10 Intervertebral Disc Degeneration - drug therapy Intervertebral discs IVD degeneration Kaempferol Kaempferols - therapeutic use Lipid metabolism Lipopolysaccharides Lipopolysaccharides - immunology Matrix metalloproteinase Matrix Metalloproteinase 3 - metabolism Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - physiology Mesenchyme Metalloproteinase Mitosis Nuclei (cytology) Osteogenesis Osteogenesis - drug effects Osteoporosis PPAR gamma - metabolism Rabbits Regeneration Socioeconomic factors SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism Spinal cord Staining Stem cells Toxicity Translocation
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