THE HLA-G 14-BASE PAIR DELETION ALLELE AND THE DELETION/DELETION GENOTYPE ARE ASSOCIATED WITH PERSISTENT HBE ANTIGENEMIA IN CHRONIC HEPATIS B INFECTION

Abstract Background and aims HLA-G has well-recognized immunomodulatory properties, and this molecule is frequently expressed in the livers of hepatitis B virus (HBV)-infected patients. Because the HLA-G 14 bp-insertion/deletion polymorphism (rs371194629) has been associated with the magnitude of HL...

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Veröffentlicht in:	Human immunology 2017-02, Vol.78 (2), p.166-171
Hauptverfasser:	da Costa Ferreira, Sandro, Gama Florêncio Chachá, Silvana, Fernandes Souza, Fernanda, Corrêa Teixeira, Andreza, de Carvalho Santana, Rodrigo, Hassan Saloun Deghaide, Neifi, Rodrigues, Sandra, Marano, Leonardo A, Teixeira Mendes-Junior, Celso, Naira Zambelli Ramalho, Leandra, Zucoloto, Sérgio, Antônio Donadi, Eduardo, de Lourdes Candolo Martinelli, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	14 bp-insertion/deletion (I/D) Adolescent Adult Aged Allergy and Immunology Antigens, Viral - metabolism Carrier State Child Chronic hepatitis B Female Follow-Up Studies Gene Frequency Genotype HBeAg-positive Hepatitis B virus - physiology Hepatitis B, Chronic - genetics HLA-G HLA-G Antigens - genetics Humans INDEL Mutation - genetics Male Middle Aged Polymorphism, Single Nucleotide Viremia - genetics Young Adult
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