Dextran sulphate sodium colitis in C57BL/6J mice is alleviated by Lactococcus lactis and worsened by the neutralization of Tumor necrosis Factor α

TNFα has a well-established role in inflammatory bowel disease that affects the gastrointestinal tract and is usually manifested as Crohn's disease or ulcerative colitis. We have compared Lactococcus lactis NZ9000 displaying TNFα-binding affibody with control Lactococcus lactis and with anti-TN...

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Veröffentlicht in:	International immunopharmacology 2017-02, Vol.43, p.219-226
Hauptverfasser:	Berlec, Aleš, Perše, Martina, Ravnikar, Matjaž, Lunder, Mojca, Erman, Andreja, Cerar, Anton, Štrukelj, Borut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - therapeutic use Bacteria Binding Colitis Colitis - chemically induced Colitis - therapy Colon Colon - drug effects Colon - immunology Crohn's disease Dextran Dextran Sulfate Digestive system DSS model Female Gastrointestinal tract Humans Inflammatory bowel disease Inflammatory bowel diseases Infliximab Infliximab - therapeutic use Intestinal Mucosa - drug effects Intestine Laboratory animals Lactococcus lactis Lactococcus lactis - chemistry Lactococcus lactis - immunology Mice Mice, Inbred C57BL Monoclonal antibodies Neutralization Oral administration Signal Transduction - drug effects Sodium Sulfates TNFα neutralization Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-TNF Tumor necrosis factor-α Ulcerative colitis
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