Site-1 protease is required for the generation of soluble (pro)renin receptor

The extracellular domain of the (pro)renin receptor [(P)RR] is cleaved to generate the soluble form of (P)RR [s(P)RR]. Multiple clinical studies have revealed the association between serum/plasma s(P)RR levels and certain diseases, thereby suggesting a potential role for s(P)RR as a disease biomarke...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2017-04, Vol.161 (4), p.369-379
Hauptverfasser:	Nakagawa, Tsutomu, Suzuki-Nakagawa, Chiharu, Watanabe, Akiko, Asami, Eriko, Matsumoto, Mizuki, Nakano, Mami, Ebihara, Akio, Uddin, Mohammad Nasir, Suzuki, Fumiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Brefeldin A - pharmacology CHO Cells Cricetinae Cricetulus Furin - metabolism HeLa Cells Humans Immunoblotting Models, Biological Proprotein Convertases - antagonists & inhibitors Proprotein Convertases - genetics Proprotein Convertases - metabolism Protease Inhibitors - pharmacology Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RNA Interference Sequence Homology, Amino Acid Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Solubility
Online-Zugang:	Volltext
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