Genetic and epigenetic effects in sex determination
Sex determination is a complex and dynamic process with multiple genetic and environmental causes, in which germ and somatic cells receive various sex‐specific features. During the fifth week of fetal life, the bipotential embryonic gonad starts to develop in humans. In the bipotential gonadal tissu...
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| Veröffentlicht in: | Birth defects research. Part C. Embryo today 2016-12, Vol.108 (4), p.321-336 |
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| container_title | Birth defects research. Part C. Embryo today |
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| creator | Gunes, Sezgin Ozgur Metin Mahmutoglu, Asli Agarwal, Ashok |
| description | Sex determination is a complex and dynamic process with multiple genetic and environmental causes, in which germ and somatic cells receive various sex‐specific features. During the fifth week of fetal life, the bipotential embryonic gonad starts to develop in humans. In the bipotential gonadal tissue, certain cell groups start to differentiate to form the ovaries or testes. Despite considerable efforts and advances in identifying the mechanisms playing a role in sex determination and differentiation, the underlying mechanisms of the exact functions of many genes, gene–gene interactions, and epigenetic modifications that are involved in different stages of this cascade are not completely understood. This review aims at discussing current data on the genetic effects via genes and epigenetic mechanisms that affect the regulation of sex determination. Birth Defects Research (Part C) 108:321–336, 2016. © 2016 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/bdrc.21146 |
| format | Article |
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| subjects | epigenetics Epigenomics Female GATA4 Genes, sry - genetics Gonads - physiology Humans Male NR5A1 sex determination Sex Determination Analysis - methods Sex Determination Processes - genetics Sex Differentiation - genetics SOXE SOXE Transcription Factors - genetics SRY Transcription Factors - genetics WT1 |
| title | Genetic and epigenetic effects in sex determination |
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