Effects of Lycium barbarum polysaccharides on the damage to human endometrial stromal cells induced by hydrogen peroxide
Previous studies have shown that Lycium barbarum polysaccharides (LBPs) serve an important role in antioxidant activity to protect the cells and tissues. However, the specific mechanism of LBPs in the prevention of endometrial damage remains to be elucidated. Using morphological observation, cell pr...
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| Veröffentlicht in: | Molecular medicine reports 2017-02, Vol.15 (2), p.879-884 |
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| description | Previous studies have shown that Lycium barbarum polysaccharides (LBPs) serve an important role in antioxidant activity to protect the cells and tissues. However, the specific mechanism of LBPs in the prevention of endometrial damage remains to be elucidated. Using morphological observation, cell proliferation assay, the detection of superoxide dismutase (SOD) activity and the content of malondialdehyde (MDA) in cell culture supernatant fluid, the detection by western blot analysis and reverse transcription-quantitative polymerase chain reaction of the mRNA and protein expression levels of caspase-3 and Bcl-2 in endometrial stromal cells (ESCs), it was demonstrated that, in vitro, hydrogen peroxide (H2O2)-induced death of ESCs, increased the content of MDA and decreased the activity of SOD, and decreased the expression of Bcl-2 and increased the expression of caspase-3. LBPs can inhibit H2O2-induced cell death of ESCs, decrease the content of MDA in ESCs and increase the activity of SOD, as well as increasing the expression of Bcl-2 and decreasing the expression levels of caspase-3. These findings suggested that LBPs can inhibit H2O2-induced apoptosis of EECs and that LBPs are able to offer a significant protection against oxidative stress to ESCs. |
| doi_str_mv | 10.3892/mmr.2016.6080 |
| format | Article |
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However, the specific mechanism of LBPs in the prevention of endometrial damage remains to be elucidated. Using morphological observation, cell proliferation assay, the detection of superoxide dismutase (SOD) activity and the content of malondialdehyde (MDA) in cell culture supernatant fluid, the detection by western blot analysis and reverse transcription-quantitative polymerase chain reaction of the mRNA and protein expression levels of caspase-3 and Bcl-2 in endometrial stromal cells (ESCs), it was demonstrated that, in vitro, hydrogen peroxide (H2O2)-induced death of ESCs, increased the content of MDA and decreased the activity of SOD, and decreased the expression of Bcl-2 and increased the expression of caspase-3. LBPs can inhibit H2O2-induced cell death of ESCs, decrease the content of MDA in ESCs and increase the activity of SOD, as well as increasing the expression of Bcl-2 and decreasing the expression levels of caspase-3. These findings suggested that LBPs can inhibit H2O2-induced apoptosis of EECs and that LBPs are able to offer a significant protection against oxidative stress to ESCs.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2016.6080</identifier><identifier>PMID: 28035381</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Adult ; Antioxidants ; Antioxidants - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Bcl-2 protein ; Caspase ; Caspase 3 - metabolism ; Caspase-3 ; Cell culture ; Cell death ; Cell growth ; Cell proliferation ; Cells, Cultured ; Chinese medicine ; Cytochrome ; Drugs, Chinese Herbal - pharmacology ; Endometrium ; Endometrium - cytology ; Endometrium - drug effects ; Endometrium - metabolism ; Female ; Gene expression ; Goji berries ; human endometrial stromal cell ; Humans ; Hydrogen peroxide ; Hydrogen Peroxide - toxicity ; Infertility ; Lycium - chemistry ; Lycium barbarum ; Lycium barbarum polysaccharides ; Malondialdehyde ; Malondialdehyde - metabolism ; Mammals ; Middle Aged ; Mitochondria ; Morphology ; Oxidative stress ; Oxidative Stress - drug effects ; Penicillin ; Physiological aspects ; Physiology ; Polymerase chain reaction ; Polysaccharides ; Prevention ; Proteins ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Reproductive technologies ; Reverse transcription ; Stromal cells ; Stromal Cells - cytology ; Stromal Cells - drug effects ; Stromal Cells - metabolism ; Studies ; Superoxide dismutase ; Superoxide Dismutase - metabolism</subject><ispartof>Molecular medicine reports, 2017-02, Vol.15 (2), p.879-884</ispartof><rights>Copyright © 2017, Spandidos Publications</rights><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-6f9dd51abbf6161327a662706436b6caa4a47f5063b5c005d49493286d0c92583</citedby><cites>FETCH-LOGICAL-c459t-6f9dd51abbf6161327a662706436b6caa4a47f5063b5c005d49493286d0c92583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28035381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shan, Tieying</creatorcontrib><creatorcontrib>Shan, Tieqiang</creatorcontrib><creatorcontrib>Liu, Fengli</creatorcontrib><creatorcontrib>Zheng, Haiping</creatorcontrib><creatorcontrib>Li, Guiying</creatorcontrib><title>Effects of Lycium barbarum polysaccharides on the damage to human endometrial stromal cells induced by hydrogen peroxide</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Previous studies have shown that Lycium barbarum polysaccharides (LBPs) serve an important role in antioxidant activity to protect the cells and tissues. However, the specific mechanism of LBPs in the prevention of endometrial damage remains to be elucidated. Using morphological observation, cell proliferation assay, the detection of superoxide dismutase (SOD) activity and the content of malondialdehyde (MDA) in cell culture supernatant fluid, the detection by western blot analysis and reverse transcription-quantitative polymerase chain reaction of the mRNA and protein expression levels of caspase-3 and Bcl-2 in endometrial stromal cells (ESCs), it was demonstrated that, in vitro, hydrogen peroxide (H2O2)-induced death of ESCs, increased the content of MDA and decreased the activity of SOD, and decreased the expression of Bcl-2 and increased the expression of caspase-3. LBPs can inhibit H2O2-induced cell death of ESCs, decrease the content of MDA in ESCs and increase the activity of SOD, as well as increasing the expression of Bcl-2 and decreasing the expression levels of caspase-3. These findings suggested that LBPs can inhibit H2O2-induced apoptosis of EECs and that LBPs are able to offer a significant protection against oxidative stress to ESCs.</description><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bcl-2 protein</subject><subject>Caspase</subject><subject>Caspase 3 - metabolism</subject><subject>Caspase-3</subject><subject>Cell culture</subject><subject>Cell death</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Cells, Cultured</subject><subject>Chinese medicine</subject><subject>Cytochrome</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Endometrium</subject><subject>Endometrium - cytology</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - metabolism</subject><subject>Female</subject><subject>Gene expression</subject><subject>Goji berries</subject><subject>human endometrial stromal cell</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - toxicity</subject><subject>Infertility</subject><subject>Lycium - chemistry</subject><subject>Lycium barbarum</subject><subject>Lycium barbarum polysaccharides</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - metabolism</subject><subject>Mammals</subject><subject>Middle Aged</subject><subject>Mitochondria</subject><subject>Morphology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Penicillin</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Polymerase chain reaction</subject><subject>Polysaccharides</subject><subject>Prevention</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Reproductive technologies</subject><subject>Reverse transcription</subject><subject>Stromal cells</subject><subject>Stromal Cells - cytology</subject><subject>Stromal Cells - drug effects</subject><subject>Stromal Cells - metabolism</subject><subject>Studies</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkUuLFDEUhQtRnIcu3UrAhW6qzbsqy2EYHaHBja5DKo_uDJWkTKpg6t9Pim5HFEngXsJ3zz3kNM07BHekF_hzCHmHIeI7Dnv4orlEnUAtgZC-PPdYiO6iuSrlAULOMBOvmwvcQ8JIjy6bxzvnrJ4LSA7sV-2XAAaV663NlMa1KK2PKntjKxLBfLTAqKAOFswJHJegIrDRpGDn7NUIypxTqFXbcSzAR7Noa8CwguNqcjrYCCab02OVe9O8cmos9u25Xjc_v9z9uL1v99-_fru92beaMjG33AljGFLD4DjiiOBOcY47yCnhA9dKUUU7xyAnA9MQMkMFFQT33EAtMOvJdfPppDvl9GuxZZbBl82eijYtRaKeUY462qGKfvgHfUhLjtWdRILXn8OCsz_UQY1W-ujSnJXeROVNXU1pT-CmtfsPVY-xwesUrfP1_a-B9jSgcyolWyen7IPKq0RQbknLmrTckpZb0pV_fza7DMGaZ_p3tBX4eALKpKLxJpVnpiq1iLUQt7DvBHkCguOvvw</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Shan, Tieying</creator><creator>Shan, Tieqiang</creator><creator>Liu, Fengli</creator><creator>Zheng, Haiping</creator><creator>Li, Guiying</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Effects of Lycium barbarum polysaccharides on the damage to human endometrial stromal cells induced by hydrogen peroxide</title><author>Shan, Tieying ; Shan, Tieqiang ; Liu, Fengli ; Zheng, Haiping ; Li, Guiying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-6f9dd51abbf6161327a662706436b6caa4a47f5063b5c005d49493286d0c92583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - 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Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shan, Tieying</au><au>Shan, Tieqiang</au><au>Liu, Fengli</au><au>Zheng, Haiping</au><au>Li, Guiying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Lycium barbarum polysaccharides on the damage to human endometrial stromal cells induced by hydrogen peroxide</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>15</volume><issue>2</issue><spage>879</spage><epage>884</epage><pages>879-884</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Previous studies have shown that Lycium barbarum polysaccharides (LBPs) serve an important role in antioxidant activity to protect the cells and tissues. However, the specific mechanism of LBPs in the prevention of endometrial damage remains to be elucidated. Using morphological observation, cell proliferation assay, the detection of superoxide dismutase (SOD) activity and the content of malondialdehyde (MDA) in cell culture supernatant fluid, the detection by western blot analysis and reverse transcription-quantitative polymerase chain reaction of the mRNA and protein expression levels of caspase-3 and Bcl-2 in endometrial stromal cells (ESCs), it was demonstrated that, in vitro, hydrogen peroxide (H2O2)-induced death of ESCs, increased the content of MDA and decreased the activity of SOD, and decreased the expression of Bcl-2 and increased the expression of caspase-3. LBPs can inhibit H2O2-induced cell death of ESCs, decrease the content of MDA in ESCs and increase the activity of SOD, as well as increasing the expression of Bcl-2 and decreasing the expression levels of caspase-3. These findings suggested that LBPs can inhibit H2O2-induced apoptosis of EECs and that LBPs are able to offer a significant protection against oxidative stress to ESCs.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>28035381</pmid><doi>10.3892/mmr.2016.6080</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Bcl-2 protein Caspase Caspase 3 - metabolism Caspase-3 Cell culture Cell death Cell growth Cell proliferation Cells, Cultured Chinese medicine Cytochrome Drugs, Chinese Herbal - pharmacology Endometrium Endometrium - cytology Endometrium - drug effects Endometrium - metabolism Female Gene expression Goji berries human endometrial stromal cell Humans Hydrogen peroxide Hydrogen Peroxide - toxicity Infertility Lycium - chemistry Lycium barbarum Lycium barbarum polysaccharides Malondialdehyde Malondialdehyde - metabolism Mammals Middle Aged Mitochondria Morphology Oxidative stress Oxidative Stress - drug effects Penicillin Physiological aspects Physiology Polymerase chain reaction Polysaccharides Prevention Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Reproductive technologies Reverse transcription Stromal cells Stromal Cells - cytology Stromal Cells - drug effects Stromal Cells - metabolism Studies Superoxide dismutase Superoxide Dismutase - metabolism |
| title | Effects of Lycium barbarum polysaccharides on the damage to human endometrial stromal cells induced by hydrogen peroxide |
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