Marek’s disease vaccines: Current status, and strategies for improvement and development of vector vaccines
•Current state of vaccination for the control of Marek’s disease virus.•Strategies for the development of improved Marek’s disease vaccines.•Marek’s disease vector vaccines for the control of important diseases of poultry. Marek’s disease (MD) is a lymphoproliferative viral disease of chickens, whic...
Gespeichert in:
Veröffentlicht in: | Veterinary microbiology 2017-07, Vol.206, p.113-120 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 120 |
---|---|
container_issue | |
container_start_page | 113 |
container_title | Veterinary microbiology |
container_volume | 206 |
creator | Reddy, Sanjay M. Izumiya, Yoshihiro Lupiani, Blanca |
description | •Current state of vaccination for the control of Marek’s disease virus.•Strategies for the development of improved Marek’s disease vaccines.•Marek’s disease vector vaccines for the control of important diseases of poultry.
Marek’s disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases. |
doi_str_mv | 10.1016/j.vetmic.2016.11.024 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1854616340</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378113516307015</els_id><sourcerecordid>1963135349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-59ea902ed46a1db423f8c17ddea208816060e4dccf51c93bba0b3d9d014f08963</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxi1ExS6FN0AoEhcOJMzEjtfhUAmt-FNpKy5wthx7grxsksVOInHjNXi9Pkm9pO2hh55mRv7N59H3MfYKoUBA-X5fzDR23hZlmgrEAkrxhK1RbXheVqJ8ytbANypH5NWKPY9xDwCilvCMrUoFXCmp1qy7MoF-Xf_9FzPnI5lI2Wys9T3FD9l2CoH6MYujGaf4LjO9S30wI_30FLN2CJnvjmGYqTthp2dHMx2G4_95aLOZ7JioO8kX7Kw1h0gvb-s5-_H50_ft13z37cvl9uMut4LLMa9qMjWU5IQ06BpR8lZZ3DhHpgSlUIIEEs7atkJb86Yx0HBXO0DRgqolP2dvF9103O-J4qg7Hy0dDqanYYoaVSUkSi4goW8eoPthCn26TmNSSuZxUSdKLJQNQ4yBWn0MvjPhj0bQpzj0Xi9x6FMcGlGnONLa61vxqenI3S_d-Z-AiwWg5MbsKehoPfWWnA_JOu0G__gPN8Byn4E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1963135349</pqid></control><display><type>article</type><title>Marek’s disease vaccines: Current status, and strategies for improvement and development of vector vaccines</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Reddy, Sanjay M. ; Izumiya, Yoshihiro ; Lupiani, Blanca</creator><creatorcontrib>Reddy, Sanjay M. ; Izumiya, Yoshihiro ; Lupiani, Blanca</creatorcontrib><description>•Current state of vaccination for the control of Marek’s disease virus.•Strategies for the development of improved Marek’s disease vaccines.•Marek’s disease vector vaccines for the control of important diseases of poultry.
Marek’s disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/j.vetmic.2016.11.024</identifier><identifier>PMID: 28038868</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animal diseases ; Animal vaccines ; Animals ; Cell culture ; Chicken ; Chickens ; Chickens - immunology ; Chickens - virology ; Herpesvirus ; Herpesvirus 2, Gallid - immunology ; Herpesvirus 2, Gallid - pathogenicity ; Lymphocytes ; Marek Disease - prevention & control ; Marek Disease - virology ; Marek's disease ; Poultry ; Poultry Diseases - prevention & control ; Poultry Diseases - virology ; Recombinant ; Recombinant DNA ; Strains (organisms) ; Tumors ; Vaccination - veterinary ; Vaccine ; Vaccines ; Vector ; Viral Vaccines - immunology ; Virulence ; Viruses</subject><ispartof>Veterinary microbiology, 2017-07, Vol.206, p.113-120</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier B.V.</rights><rights>Copyright Elsevier BV Jul 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-59ea902ed46a1db423f8c17ddea208816060e4dccf51c93bba0b3d9d014f08963</citedby><cites>FETCH-LOGICAL-c436t-59ea902ed46a1db423f8c17ddea208816060e4dccf51c93bba0b3d9d014f08963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vetmic.2016.11.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28038868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reddy, Sanjay M.</creatorcontrib><creatorcontrib>Izumiya, Yoshihiro</creatorcontrib><creatorcontrib>Lupiani, Blanca</creatorcontrib><title>Marek’s disease vaccines: Current status, and strategies for improvement and development of vector vaccines</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>•Current state of vaccination for the control of Marek’s disease virus.•Strategies for the development of improved Marek’s disease vaccines.•Marek’s disease vector vaccines for the control of important diseases of poultry.
Marek’s disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.</description><subject>Animal diseases</subject><subject>Animal vaccines</subject><subject>Animals</subject><subject>Cell culture</subject><subject>Chicken</subject><subject>Chickens</subject><subject>Chickens - immunology</subject><subject>Chickens - virology</subject><subject>Herpesvirus</subject><subject>Herpesvirus 2, Gallid - immunology</subject><subject>Herpesvirus 2, Gallid - pathogenicity</subject><subject>Lymphocytes</subject><subject>Marek Disease - prevention & control</subject><subject>Marek Disease - virology</subject><subject>Marek's disease</subject><subject>Poultry</subject><subject>Poultry Diseases - prevention & control</subject><subject>Poultry Diseases - virology</subject><subject>Recombinant</subject><subject>Recombinant DNA</subject><subject>Strains (organisms)</subject><subject>Tumors</subject><subject>Vaccination - veterinary</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Vector</subject><subject>Viral Vaccines - immunology</subject><subject>Virulence</subject><subject>Viruses</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi1ExS6FN0AoEhcOJMzEjtfhUAmt-FNpKy5wthx7grxsksVOInHjNXi9Pkm9pO2hh55mRv7N59H3MfYKoUBA-X5fzDR23hZlmgrEAkrxhK1RbXheVqJ8ytbANypH5NWKPY9xDwCilvCMrUoFXCmp1qy7MoF-Xf_9FzPnI5lI2Wys9T3FD9l2CoH6MYujGaf4LjO9S30wI_30FLN2CJnvjmGYqTthp2dHMx2G4_95aLOZ7JioO8kX7Kw1h0gvb-s5-_H50_ft13z37cvl9uMut4LLMa9qMjWU5IQ06BpR8lZZ3DhHpgSlUIIEEs7atkJb86Yx0HBXO0DRgqolP2dvF9103O-J4qg7Hy0dDqanYYoaVSUkSi4goW8eoPthCn26TmNSSuZxUSdKLJQNQ4yBWn0MvjPhj0bQpzj0Xi9x6FMcGlGnONLa61vxqenI3S_d-Z-AiwWg5MbsKehoPfWWnA_JOu0G__gPN8Byn4E</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Reddy, Sanjay M.</creator><creator>Izumiya, Yoshihiro</creator><creator>Lupiani, Blanca</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Marek’s disease vaccines: Current status, and strategies for improvement and development of vector vaccines</title><author>Reddy, Sanjay M. ; Izumiya, Yoshihiro ; Lupiani, Blanca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-59ea902ed46a1db423f8c17ddea208816060e4dccf51c93bba0b3d9d014f08963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal diseases</topic><topic>Animal vaccines</topic><topic>Animals</topic><topic>Cell culture</topic><topic>Chicken</topic><topic>Chickens</topic><topic>Chickens - immunology</topic><topic>Chickens - virology</topic><topic>Herpesvirus</topic><topic>Herpesvirus 2, Gallid - immunology</topic><topic>Herpesvirus 2, Gallid - pathogenicity</topic><topic>Lymphocytes</topic><topic>Marek Disease - prevention & control</topic><topic>Marek Disease - virology</topic><topic>Marek's disease</topic><topic>Poultry</topic><topic>Poultry Diseases - prevention & control</topic><topic>Poultry Diseases - virology</topic><topic>Recombinant</topic><topic>Recombinant DNA</topic><topic>Strains (organisms)</topic><topic>Tumors</topic><topic>Vaccination - veterinary</topic><topic>Vaccine</topic><topic>Vaccines</topic><topic>Vector</topic><topic>Viral Vaccines - immunology</topic><topic>Virulence</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reddy, Sanjay M.</creatorcontrib><creatorcontrib>Izumiya, Yoshihiro</creatorcontrib><creatorcontrib>Lupiani, Blanca</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reddy, Sanjay M.</au><au>Izumiya, Yoshihiro</au><au>Lupiani, Blanca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Marek’s disease vaccines: Current status, and strategies for improvement and development of vector vaccines</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>2017-07</date><risdate>2017</risdate><volume>206</volume><spage>113</spage><epage>120</epage><pages>113-120</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><abstract>•Current state of vaccination for the control of Marek’s disease virus.•Strategies for the development of improved Marek’s disease vaccines.•Marek’s disease vector vaccines for the control of important diseases of poultry.
Marek’s disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28038868</pmid><doi>10.1016/j.vetmic.2016.11.024</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0378-1135 |
ispartof | Veterinary microbiology, 2017-07, Vol.206, p.113-120 |
issn | 0378-1135 1873-2542 |
language | eng |
recordid | cdi_proquest_miscellaneous_1854616340 |
source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | Animal diseases Animal vaccines Animals Cell culture Chicken Chickens Chickens - immunology Chickens - virology Herpesvirus Herpesvirus 2, Gallid - immunology Herpesvirus 2, Gallid - pathogenicity Lymphocytes Marek Disease - prevention & control Marek Disease - virology Marek's disease Poultry Poultry Diseases - prevention & control Poultry Diseases - virology Recombinant Recombinant DNA Strains (organisms) Tumors Vaccination - veterinary Vaccine Vaccines Vector Viral Vaccines - immunology Virulence Viruses |
title | Marek’s disease vaccines: Current status, and strategies for improvement and development of vector vaccines |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T22%3A36%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Marek%E2%80%99s%20disease%20vaccines:%20Current%20status,%20and%20strategies%20for%20improvement%20and%20development%20of%20vector%20vaccines&rft.jtitle=Veterinary%20microbiology&rft.au=Reddy,%20Sanjay%20M.&rft.date=2017-07&rft.volume=206&rft.spage=113&rft.epage=120&rft.pages=113-120&rft.issn=0378-1135&rft.eissn=1873-2542&rft_id=info:doi/10.1016/j.vetmic.2016.11.024&rft_dat=%3Cproquest_cross%3E1963135349%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1963135349&rft_id=info:pmid/28038868&rft_els_id=S0378113516307015&rfr_iscdi=true |