SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex
The development of the cerebral cortex requires the coordination of multiple processes ranging from the proliferation of progenitors to the migration and establishment of connectivity of the newborn neurons. Epigenetic regulation carried out by the COREST/LSD1 complex has been identified as a mechan...
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| Veröffentlicht in: | International journal of developmental neuroscience 2017-04, Vol.57 (1), p.1-11 |
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| container_title | International journal of developmental neuroscience |
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| creator | Saud, K. Cánovas, J. Lopez, C.I. Berndt, F.A. López, E. Maass, J.C. Barriga, A. Kukuljan, M. |
| description | The development of the cerebral cortex requires the coordination of multiple processes ranging from the proliferation of progenitors to the migration and establishment of connectivity of the newborn neurons. Epigenetic regulation carried out by the COREST/LSD1 complex has been identified as a mechanism that regulates the development of pyramidal neurons of the cerebral cortex. We now identify the association of the multifunctional RNA-binding protein SFPQ to LSD1 during the development of the cerebral cortex. In vivo reduction of SFPQ dosage by in utero electroporation of a shRNA results in impaired radial migration of newborn pyramidal neurons, in a similar way to that observed when COREST or LSD1 expressions are decreased. Diminished SFPQ expression also associates to decreased proliferation of progenitor cells, while it does not affect the acquisition of neuronal fate. These results are compatible with the idea that SFPQ, plays an important role regulating proliferation and migration during the development of the cerebral cortex. |
| doi_str_mv | 10.1016/j.ijdevneu.2016.12.006 |
| format | Article |
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Epigenetic regulation carried out by the COREST/LSD1 complex has been identified as a mechanism that regulates the development of pyramidal neurons of the cerebral cortex. We now identify the association of the multifunctional RNA-binding protein SFPQ to LSD1 during the development of the cerebral cortex. In vivo reduction of SFPQ dosage by in utero electroporation of a shRNA results in impaired radial migration of newborn pyramidal neurons, in a similar way to that observed when COREST or LSD1 expressions are decreased. Diminished SFPQ expression also associates to decreased proliferation of progenitor cells, while it does not affect the acquisition of neuronal fate. These results are compatible with the idea that SFPQ, plays an important role regulating proliferation and migration during the development of the cerebral cortex.</description><identifier>ISSN: 0736-5748</identifier><identifier>EISSN: 1873-474X</identifier><identifier>DOI: 10.1016/j.ijdevneu.2016.12.006</identifier><identifier>PMID: 28034769</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Age Factors ; Animals ; Animals, Newborn ; Brain ; Cell Line ; Cell Movement - genetics ; Cell Movement - physiology ; Cell proliferation ; Cells (biology) ; Cerebral cortex ; Cerebral Cortex - cytology ; Cerebral Cortex - embryology ; Cerebral Cortex - growth & development ; Corticogenesis ; Dosage ; Electroporation ; Embryo, Mammalian ; Epigenetic regulation ; Epigenetics ; Gene Expression Regulation, Developmental - genetics ; Gene Expression Regulation, Developmental - physiology ; Histone Demethylases - genetics ; Histone Demethylases - metabolism ; Homeodomain Proteins - metabolism ; Ki-67 Antigen - metabolism ; Mice ; Microtubule-Associated Proteins - metabolism ; Neural networks ; Neural stem cells ; Neuronal migration ; Neurons ; Neuropeptides - metabolism ; Newborn babies ; Nuclear Proteins - metabolism ; PTB-Associated Splicing Factor - genetics ; PTB-Associated Splicing Factor - metabolism ; Pyramidal cells ; Pyramidal Cells - physiology ; Repressor Proteins - metabolism ; Ribonucleic acid ; RNA ; RNA, Small Interfering - genetics ; RNA, Small Interfering - metabolism ; RNA-binding protein ; SOXB1 Transcription Factors - metabolism</subject><ispartof>International journal of developmental neuroscience, 2017-04, Vol.57 (1), p.1-11</ispartof><rights>2016 ISDN</rights><rights>2017 ISDN</rights><rights>Copyright © 2016 ISDN. 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Epigenetic regulation carried out by the COREST/LSD1 complex has been identified as a mechanism that regulates the development of pyramidal neurons of the cerebral cortex. We now identify the association of the multifunctional RNA-binding protein SFPQ to LSD1 during the development of the cerebral cortex. In vivo reduction of SFPQ dosage by in utero electroporation of a shRNA results in impaired radial migration of newborn pyramidal neurons, in a similar way to that observed when COREST or LSD1 expressions are decreased. Diminished SFPQ expression also associates to decreased proliferation of progenitor cells, while it does not affect the acquisition of neuronal fate. These results are compatible with the idea that SFPQ, plays an important role regulating proliferation and migration during the development of the cerebral cortex.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Brain</subject><subject>Cell Line</subject><subject>Cell Movement - genetics</subject><subject>Cell Movement - physiology</subject><subject>Cell proliferation</subject><subject>Cells (biology)</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - embryology</subject><subject>Cerebral Cortex - growth & development</subject><subject>Corticogenesis</subject><subject>Dosage</subject><subject>Electroporation</subject><subject>Embryo, Mammalian</subject><subject>Epigenetic regulation</subject><subject>Epigenetics</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Histone Demethylases - genetics</subject><subject>Histone Demethylases - metabolism</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Mice</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Neural networks</subject><subject>Neural stem cells</subject><subject>Neuronal migration</subject><subject>Neurons</subject><subject>Neuropeptides - metabolism</subject><subject>Newborn babies</subject><subject>Nuclear Proteins - metabolism</subject><subject>PTB-Associated Splicing Factor - genetics</subject><subject>PTB-Associated Splicing Factor - metabolism</subject><subject>Pyramidal cells</subject><subject>Pyramidal Cells - physiology</subject><subject>Repressor Proteins - metabolism</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Small Interfering - genetics</subject><subject>RNA, Small Interfering - metabolism</subject><subject>RNA-binding protein</subject><subject>SOXB1 Transcription Factors - metabolism</subject><issn>0736-5748</issn><issn>1873-474X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVFv0zAUhSMEYmXwFyZLvPDSYjuOnbyB1o61qgZoDPFmOfZNcZTYnZ1s67_HJRsPvMDTlY--e-6RT5adEbwgmPD37cK2Bu4cjAua3gtCFxjzZ9mMlCKfM8F-PM9mWOR8XghWnmSvYmwxxkWB2cvshJY4Z4JXsyxcX3z5ilSMXls1QESDR9vrJUHKGRRgN3aT-hNQb3dBDdY75Bvk4L72waH9IajeGtUlZQzeRWTdbzqFg87vrdshDQHqkBDtwwAPr7MXjeoivHmcp9nNxerb-eV8-_nT-vzjdq4Zp3yek7owJVWkUWVjuFB5ZbjGFBtSUiJMpRltDMsxrknBABjXjagqVuRgGNA6P83eTb774G9HiIPsbdTQdcqBH6MkZcE44UTkCX37F9r6MbiUTpIqp4QITkWi-ETp4GMM0Mh9sL0KB0mwPLYiW_nUijy2IgmVqZW0ePZoP9Y9mD9rTzUkYD0B97aDw3_ays3yarPeLFffr1Y3R53Q6diHyQvS395ZCDJqC06DsQH0II23_8r7C04ouEQ</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Saud, K.</creator><creator>Cánovas, J.</creator><creator>Lopez, C.I.</creator><creator>Berndt, F.A.</creator><creator>López, E.</creator><creator>Maass, J.C.</creator><creator>Barriga, A.</creator><creator>Kukuljan, M.</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex</title><author>Saud, K. ; Cánovas, J. ; Lopez, C.I. ; Berndt, F.A. ; López, E. ; Maass, J.C. ; Barriga, A. ; Kukuljan, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4626-31b5d82a1fa8fd67a39d6c020d18217d9c42fd4300b154ee46cf799453ed4e2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Brain</topic><topic>Cell Line</topic><topic>Cell Movement - genetics</topic><topic>Cell Movement - physiology</topic><topic>Cell proliferation</topic><topic>Cells (biology)</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - embryology</topic><topic>Cerebral Cortex - growth & development</topic><topic>Corticogenesis</topic><topic>Dosage</topic><topic>Electroporation</topic><topic>Embryo, Mammalian</topic><topic>Epigenetic regulation</topic><topic>Epigenetics</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Histone Demethylases - genetics</topic><topic>Histone Demethylases - metabolism</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Mice</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Neural networks</topic><topic>Neural stem cells</topic><topic>Neuronal migration</topic><topic>Neurons</topic><topic>Neuropeptides - metabolism</topic><topic>Newborn babies</topic><topic>Nuclear Proteins - metabolism</topic><topic>PTB-Associated Splicing Factor - genetics</topic><topic>PTB-Associated Splicing Factor - metabolism</topic><topic>Pyramidal cells</topic><topic>Pyramidal Cells - physiology</topic><topic>Repressor Proteins - metabolism</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Small Interfering - genetics</topic><topic>RNA, Small Interfering - metabolism</topic><topic>RNA-binding protein</topic><topic>SOXB1 Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saud, K.</creatorcontrib><creatorcontrib>Cánovas, J.</creatorcontrib><creatorcontrib>Lopez, C.I.</creatorcontrib><creatorcontrib>Berndt, F.A.</creatorcontrib><creatorcontrib>López, E.</creatorcontrib><creatorcontrib>Maass, J.C.</creatorcontrib><creatorcontrib>Barriga, A.</creatorcontrib><creatorcontrib>Kukuljan, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of developmental neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saud, K.</au><au>Cánovas, J.</au><au>Lopez, C.I.</au><au>Berndt, F.A.</au><au>López, E.</au><au>Maass, J.C.</au><au>Barriga, A.</au><au>Kukuljan, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex</atitle><jtitle>International journal of developmental neuroscience</jtitle><addtitle>Int J Dev Neurosci</addtitle><date>2017-04</date><risdate>2017</risdate><volume>57</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0736-5748</issn><eissn>1873-474X</eissn><abstract>The development of the cerebral cortex requires the coordination of multiple processes ranging from the proliferation of progenitors to the migration and establishment of connectivity of the newborn neurons. Epigenetic regulation carried out by the COREST/LSD1 complex has been identified as a mechanism that regulates the development of pyramidal neurons of the cerebral cortex. We now identify the association of the multifunctional RNA-binding protein SFPQ to LSD1 during the development of the cerebral cortex. In vivo reduction of SFPQ dosage by in utero electroporation of a shRNA results in impaired radial migration of newborn pyramidal neurons, in a similar way to that observed when COREST or LSD1 expressions are decreased. Diminished SFPQ expression also associates to decreased proliferation of progenitor cells, while it does not affect the acquisition of neuronal fate. These results are compatible with the idea that SFPQ, plays an important role regulating proliferation and migration during the development of the cerebral cortex.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>28034769</pmid><doi>10.1016/j.ijdevneu.2016.12.006</doi><tpages>11</tpages></addata></record> |
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| subjects | Age Factors Animals Animals, Newborn Brain Cell Line Cell Movement - genetics Cell Movement - physiology Cell proliferation Cells (biology) Cerebral cortex Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - growth & development Corticogenesis Dosage Electroporation Embryo, Mammalian Epigenetic regulation Epigenetics Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Histone Demethylases - genetics Histone Demethylases - metabolism Homeodomain Proteins - metabolism Ki-67 Antigen - metabolism Mice Microtubule-Associated Proteins - metabolism Neural networks Neural stem cells Neuronal migration Neurons Neuropeptides - metabolism Newborn babies Nuclear Proteins - metabolism PTB-Associated Splicing Factor - genetics PTB-Associated Splicing Factor - metabolism Pyramidal cells Pyramidal Cells - physiology Repressor Proteins - metabolism Ribonucleic acid RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-binding protein SOXB1 Transcription Factors - metabolism |
| title | SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex |
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