Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR

The JAK2 V617F mutant-mediated aberrant signaling pathway is a hallmark of myeloproliferative neoplasms (MPNs). Although cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are negative regulators of the JAK-STAT pathway, the functional role of CIS/SOCS famil...

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Veröffentlicht in:	Cellular signalling 2017-02, Vol.31, p.41-57
Hauptverfasser:	Funakoshi-Tago, Megumi, Moriwaki, Takuro, Ueda, Fumihito, Tamura, Hiroomi, Kasahara, Tadashi, Tago, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Carcinogenesis - metabolism Carcinogenesis - pathology Cell Proliferation Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology CIS Erythropoietin - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene Knockdown Techniques Humans JAK2 Janus Kinase 2 - metabolism Mice, Inbred BALB C Mice, Nude Models, Biological Mutation - genetics Myeloproliferative neoplasms (MPNs) Phosphorylation Protein Binding Receptors, Erythropoietin - metabolism SOCS1 STAT5 Transcription Factor - metabolism Suppressor of Cytokine Signaling Proteins - chemistry Suppressor of Cytokine Signaling Proteins - metabolism V617F mutation
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